Home >> Signaling Pathways >> Metabolism >> MAO


Monoamine oxidases (MAOs) are a family of enzymes that oxidize a number of biogenic amines through the production of hydrogen peroxide (H2O2). Two members of the MAO family have been identified and designated, MAO A and MAO B, which are encoded by two homologous genes comprising 15 exons with identical intro-exon organization and exhibit substrate-specificity. MAO A displays higher affinity towards serotonin, norepinephrine and dopamine; while MAO B displays higher affinity towards phenylethylamine and benzylamine.  Four highly conserved regions associated with the catalytic activity of mammalian MAO enzymes have been identified, including an ADP binding β-α-β unit, a putative substrate-binding domain, a FAD covalent attachment site, and a C terminus region predicted to form a transmembrane-associated α-helix.

  1. Cat.No. 产品名称 Information
  2. GC14122 Clorgyline (hydrochloride) A selective, irreversible monoamine oxidase A inhibitor
  3. GC16824 Pargyline (hydrochloride) An irreversible MAO inhibitor
  4. GC12962 Isatin Isatin (Indoline-2,3-dione) 是一种有效的单胺氧化酶 (MAO) 抑制剂,IC50 为 3 μM。
  5. GC11703 Moclobemide (Ro 111163) An Analytical Reference Standard
  6. GC14673 Safinamide Mesylate An inhibitor of MAO-B
  7. GC12801 Rasagiline Mesylate An inhibitor of MAO-B

6 Item(s)

per page

Set Descending Direction