MAO
Monoamine oxidases (MAOs) are a family of enzymes that oxidize a number of biogenic amines through the production of hydrogen peroxide (H2O2). Two members of the MAO family have been identified and designated, MAO A and MAO B, which are encoded by two homologous genes comprising 15 exons with identical intro-exon organization and exhibit substrate-specificity. MAO A displays higher affinity towards serotonin, norepinephrine and dopamine; while MAO B displays higher affinity towards phenylethylamine and benzylamine. Four highly conserved regions associated with the catalytic activity of mammalian MAO enzymes have been identified, including an ADP binding β-α-β unit, a putative substrate-binding domain, a FAD covalent attachment site, and a C terminus region predicted to form a transmembrane-associated α-helix.
Products for MAO
- Cat.No. 产品名称 Information
- GC14122 Clorgyline (hydrochloride) A selective, irreversible monoamine oxidase A inhibitor
- GC16824 Pargyline (hydrochloride) An irreversible MAO inhibitor
- GC12962 Isatin Isatin (Indoline-2,3-dione) 是一种有效的单胺氧化酶 (MAO) 抑制剂,IC50 为 3 μM。
- GC11703 Moclobemide (Ro 111163) An Analytical Reference Standard
- GC14673 Safinamide Mesylate An inhibitor of MAO-B
- GC12801 Rasagiline Mesylate An inhibitor of MAO-B