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MAO

Monoamine oxidases (MAOs) are a family of enzymes that oxidize a number of biogenic amines through the production of hydrogen peroxide (H2O2). Two members of the MAO family have been identified and designated, MAO A and MAO B, which are encoded by two homologous genes comprising 15 exons with identical intro-exon organization and exhibit substrate-specificity. MAO A displays higher affinity towards serotonin, norepinephrine and dopamine; while MAO B displays higher affinity towards phenylethylamine and benzylamine.  Four highly conserved regions associated with the catalytic activity of mammalian MAO enzymes have been identified, including an ADP binding β-α-β unit, a putative substrate-binding domain, a FAD covalent attachment site, and a C terminus region predicted to form a transmembrane-associated α-helix.

  1. Cat.No. 产品名称 Information
  2. GC14122 Clorgyline (hydrochloride) Clorgyline(盐酸盐)是用于科学研究的单胺氧化酶A(MAO-A)的不可逆和选择性抑制剂;结构上与 Pargyline 相关。
  3. GC16824 Pargyline (hydrochloride) Pargyline (hydrochloride) 是一种不可逆的单胺氧化酶 (MAO) 抑制剂,对 MAO-A 和 MAO-B 的 Kis 分别为 13 μM 和 0.5 μM。
  4. GC12962 Isatin Isatin (Indoline-2,3-dione) 是一种有效的单胺氧化酶 (MAO) 抑制剂,IC50 为 3 μM。
  5. GC11703 Moclobemide (Ro 111163) Moclobemide (Ro 111163) (Ro111163) 是一种脑渗透性可逆的单胺氧化酶 (MAO-A) 抑制剂,对 hMAO-A 的 IC50 为 6.061 μM。
  6. GC14673 Safinamide Mesylate Safinamide (FCE 26743; EMD 1195686) mesylate 是一种有效的、选择性的、可逆的单胺氧化酶 B (MAO-B) 抑制剂 (IC50=0.098 μM),优于 MAO-A (IC50=580 nM)。
  7. GC12801 Rasagiline Mesylate Rasagiline (R-AGN1135) mesylate 是一种高效的选择性不可逆线粒体单胺氧化酶 (MAO) 抑制剂,对大鼠脑 MAO B 和 A 活性的 IC50 分别为 4.43 nM 和 412 nM。

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