DHFR(二氢叶酸还原酶)

Dihydrofolate reductase (DHFR) is an enzyme that catalyzes the reduction of dihydrofolate (H2F) to tetrahydrofolate (H4F) utilizing nicotinamide adenine dinucleotide phosphate (NADPH) as the hydride (H-) donor, in which the pro-R hydrogen of NADPH is transferred to C6 of the pteridine ring with concomitant protonation at the N5 position. The functional DHFR gene (approximately 30 kb with six exons and five introns) has been identified to encode DHFR enzyme. Human DHFR enzyme is a monomeric protein of 186 amino acids, which is characterized by containing a highly conserved dinucleotide-binding domain consisting of seven parallel and one antiparallel β-strands intercalated by α-helices.

Cat.No. 产品名称 Information
GC16333 Cycloguanil (hydrochloride) The active metabolite of proguanil
GC17694 Pemetrexed disodium hemipenta hydrate Pemetrexed disodium hemipenta hydrate 是一种新型抗叶酸剂，LY231514 的五谷氨酸的 Ki 值分别为 1.3、7.2 和 65 nM，用于抑制胸苷酸合酶 (TS)、二氢叶酸还原酶 (DHFR) 和甘氨酰胺核糖核苷酸甲酰转移酶 (GARFT)。
GC11610 Pemetrexed An antifolate with anticancer activity
GC17867 Pyrimethamine A dihydrofolate reductase inhibitor
GC12919 Pralatrexate A dihydrofolate reductase inhibitor
GC10405 Methotrexate
甲氨蝶呤 (Amethopterin) 是一种抗代谢物和抗叶酸剂，可抑制二氢叶酸还原酶，从而阻止叶酸转化为四氢叶酸，并抑制 DNA 合成。