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Carbonic Anhydrase(碳酸酐酶)

Carbonic anhydrases (CAs) are a family of zinc containing metalloproteins that catalyze the reversible conversion of carbon dioxide (CO2) to bicarbonate with the releasing of a proton.  Being encoded by three distinct and evolutionarily unrelated gene families, CA enzymes are divided into three subfamilies, α-CAs (in vertebrates, eubacteria, algae and cytoplasm of green plants), β-CAs (in eubacteria, algae and chloroplasts of both mono- and di-cotyledons) and γ-CAs (in Archaea and some eubacteria). Through extensive studies, fourteen different CA isozymes have been identified in mammals, including four cytosolic isozymes (CA I-III and CA VII), four membrane-bound isozymes (CA IV, CA IX, CA XII and CA XIV), one mitochondrial isozyme (CA V) and one secreted isozyme (CA VI).

  1. Cat.No. 产品名称 Information
  2. GC91296 p-Carboxyphenyl Sulfate


  3. GC69209 hCAII-IN-8 hCAII-IN-8 是一种酰胺,是一种高选择性碳酸酐酶 (CA) 抑制剂,对 hCA II 的 IC50 值为 0.18 μM。
  4. GC68830 Carbonic anhydrase inhibitor 2 Carbonic anhydrase inhibitor 2 (compound 7c) 是一种碳酸酐酶 II (carbonic anhydrase II) 抑制剂,可降低青光眼兔的眼压。
  5. GP26141 CTSE Mouse CTSE Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 385 amino acids ( 21-397 a
  6. GP26135 CA8 Human, Active CA8 Human Recombinant produced in E
  7. GP26134 CA1 E.Coli CA1 E
  8. GP26133 CA1 Human, Active CA1 Human Recombinant produced in E
  9. GC66360 Girentuximab Girentuximab (G250) 是一种嵌合单克隆抗体,可与碳酸酐酶 IX (CAIX) 结合,碳酸酐酶 IX 是一种在透明细胞肾细胞癌 (ccRCC) 中广泛表达的细胞表面糖蛋白。
  10. GC66029 hCAI/II-IN-6 hCAI/II-IN-6 是一种具有口服活性的 human carbonic anhydrase (CA) 抑制剂。hCAI/II-IN-6 选择性地抑制 hCA II 和 hCA VII,对 hCA I,hCA II,hCA VII 和 hCA XII 的 Ki 值分别为 220,4.9,6.5 和 >50000 nM。hCAI/II-IN-6 在体内显示抗惊厥活性和抗最大电击 (MES) 活性。hCAI/II-IN-6 可以用于癫痫的研究。
  11. GC65612 Acetazolamide sodium An Analytical Reference Standard
  12. GC65549 Indisulam A sulfonamide with anticancer activity
  13. GC64734 Benzenesulphonamide Benzenesulfonamide (Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide) ia an inhibitor of carbonic anhydrases.
  14. GC62864 Benzolamide Benzolamide (CL11366) 是一种有效的碳酸酐酶 (CA) 抑制剂,抑制hCA I,hCA II,EcoCAγ 和 VchCAγ 的 Ki 值分别为15 nM,9 nM,94 nM 和 78 nM。Benzolamide 还抑制 CAS3,Ki 值为 54 nM。Benzolamide 可用于青光眼和癫痫的研究。
  15. GC49337 4-Acetamidobenzenesulfonamide A metabolite of asulam and sulfanilamide
  16. GC49211 O-desmethyl Brinzolamide (hydrochloride) An active metabolite of brinzolamide
  17. GC49210 N-desethyl Brinzolamide (oxalate) An active metabolite of brinzolamide
  18. GC49195 Indapamide-13C-d3 An internal standard for the quantification of indapamide
  19. GC49194 Metolazone-d7 An internal standard for the quantification of metolazone
  20. GC48895 Rufinamide-15N-d2 An internal standard for the quantification of rufinamide
  21. GC48889 Methazolamide-d6 An internal standard for the quantification of methazolamide
  22. GC47441 Hydroflumethiazide-13C-d2 An internal standard for the quantification of hydroflumethiazide
  23. GC47385 Furosemide-d5 An internal standard for the quantification of furosemide
  24. GC47210 Dichlorphenamide-13C6 An internal standard for the quantification of dichlorphenamide
  25. GC39792 Halazone Halazone (Pantocide, p-sulfondichloramidobenzoic acid) is widely used to disinfect drinking water.
  26. GC50198 Topiramate - d12 An internal standard for the quantification of topiramate
  27. GC46101 Brinzolamide-d5 An internal standard for the quantification of brinzolamide
  28. GC45802 Zonisamide-13C2,15N An internal standard for the quantification of zonisamide
  29. GC43874 Hydroflumethiazide A thiazide diuretic
  30. GC34186 2-Aminobenzenesulfonamide (Orthanilamide) 2-Aminobenzenesulfonamide (Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide) is an inhibitor of carbonic anhydrase IX.
  31. GC33491 Acetazolamide D3 AcetazolamideD3是Acetazolamide氘代化合物标准品。
  32. GC32634 Benzthiazide Benzthiazide是一种长效的利尿剂和抗高血压剂。Benzthiazide为碳酸酐酶9(carbonicanhydrase9(CA9))的抑制剂,对CA9,CA2和CA1的Ki值分别为8.0,8.8和10nM。Benzthiazide能够抑制肿瘤细胞增殖。
  33. GC31710 Ethoxzolamide (Redupresin) Ethoxzolamide (Redupresin) 是一种碳酸酐酶抑制剂,Ki 为 1 nM。
  34. GC30899 Sultiame

    A pan-CA inhibitor and an anticonvulsant

  35. GC18271 Polmacoxib An inhibitor of COX-2 and carbonic anhydrase
  36. GC17003 Benzenesulfonamide carbonic anhydrase inhibitor
  37. GC11567 Acetazolamide An Analytical Reference Standard
  38. GC14046 Methyclothiazide A thiazide diuretic
  39. GC12992 Fluorometholone Acetate A synthetic glucocorticoid
  40. GC13932 Dorzolamide An Analytical Reference Standard
  41. GC17454 Dichlorphenamide A carbonic anhydrase inhibitor
  42. GC14226 Methazolamide A carbonic anhydrase inhibitor
  43. GC15158 Tioxolone A carbonic anhydrase I inhibitor
  44. GC16149 Topiramate An anticonvulsant
  45. GC10737 Brinzolamide A potent carbonic anhydrase inhibitor
  46. GC17378 U-104 A carbonic anhydrase inhibitor
  47. GC17748 Dorzolamide HCl A carbonic anhydrase inhibitor
  48. GN10531 Dimethylfraxetin A coumarin with anti-inflammatory activity

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