Carbonic Anhydrase(碳酸酐酶)
Carbonic anhydrases (CAs) are a family of zinc containing metalloproteins that catalyze the reversible conversion of carbon dioxide (CO2) to bicarbonate with the releasing of a proton. Being encoded by three distinct and evolutionarily unrelated gene families, CA enzymes are divided into three subfamilies, α-CAs (in vertebrates, eubacteria, algae and cytoplasm of green plants), β-CAs (in eubacteria, algae and chloroplasts of both mono- and di-cotyledons) and γ-CAs (in Archaea and some eubacteria). Through extensive studies, fourteen different CA isozymes have been identified in mammals, including four cytosolic isozymes (CA I-III and CA VII), four membrane-bound isozymes (CA IV, CA IX, CA XII and CA XIV), one mitochondrial isozyme (CA V) and one secreted isozyme (CA VI).
- Cat.No. 产品名称 Information
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GC91296
p-Carboxyphenyl Sulfate
一种硫酸化的酚酸。
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GC69209
hCAII-IN-8
hCAII-IN-8 是一种酰胺,是一种高选择性碳酸酐酶 (CA) 抑制剂,对 hCA II 的 IC50 值为 0.18 μM。
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GC68830
Carbonic anhydrase inhibitor 2
Carbonic anhydrase inhibitor 2 (compound 7c) 是一种碳酸酐酶 II (carbonic anhydrase II) 抑制剂,可降低青光眼兔的眼压。
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GP26141
CTSE Mouse
CTSE Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 385 amino acids ( 21-397 a
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GP26135
CA8 Human, Active
CA8 Human Recombinant produced in E
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GP26134
CA1 E.Coli
CA1 E
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GP26133
CA1 Human, Active
CA1 Human Recombinant produced in E
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GC66360
Girentuximab
Girentuximab (G250) 是一种嵌合单克隆抗体,可与碳酸酐酶 IX (CAIX) 结合,碳酸酐酶 IX 是一种在透明细胞肾细胞癌 (ccRCC) 中广泛表达的细胞表面糖蛋白。
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GC66029
hCAI/II-IN-6
hCAI/II-IN-6 是一种具有口服活性的 human carbonic anhydrase (CA) 抑制剂。hCAI/II-IN-6 选择性地抑制 hCA II 和 hCA VII,对 hCA I,hCA II,hCA VII 和 hCA XII 的 Ki 值分别为 220,4.9,6.5 和 >50000 nM。hCAI/II-IN-6 在体内显示抗惊厥活性和抗最大电击 (MES) 活性。hCAI/II-IN-6 可以用于癫痫的研究。
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GC65612
Acetazolamide sodium
An Analytical Reference Standard
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GC65549
Indisulam
A sulfonamide with anticancer activity
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GC64734
Benzenesulphonamide
Benzenesulfonamide (Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide) ia an inhibitor of carbonic anhydrases.
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GC62864
Benzolamide
Benzolamide (CL11366) 是一种有效的碳酸酐酶 (CA) 抑制剂,抑制hCA I,hCA II,EcoCAγ 和 VchCAγ 的 Ki 值分别为15 nM,9 nM,94 nM 和 78 nM。Benzolamide 还抑制 CAS3,Ki 值为 54 nM。Benzolamide 可用于青光眼和癫痫的研究。
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GC49337
4-Acetamidobenzenesulfonamide
A metabolite of asulam and sulfanilamide
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GC49211
O-desmethyl Brinzolamide (hydrochloride)
An active metabolite of brinzolamide
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GC49210
N-desethyl Brinzolamide (oxalate)
An active metabolite of brinzolamide
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GC49195
Indapamide-13C-d3
An internal standard for the quantification of indapamide
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GC49194
Metolazone-d7
An internal standard for the quantification of metolazone
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GC48895
Rufinamide-15N-d2
An internal standard for the quantification of rufinamide
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GC48889
Methazolamide-d6
An internal standard for the quantification of methazolamide
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GC47441
Hydroflumethiazide-13C-d2
An internal standard for the quantification of hydroflumethiazide
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GC47385
Furosemide-d5
An internal standard for the quantification of furosemide
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GC47210
Dichlorphenamide-13C6
An internal standard for the quantification of dichlorphenamide
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GC39792
Halazone
Halazone (Pantocide, p-sulfondichloramidobenzoic acid) is widely used to disinfect drinking water.
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GC50198
Topiramate - d12
An internal standard for the quantification of topiramate
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GC46101
Brinzolamide-d5
An internal standard for the quantification of brinzolamide
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GC45802
Zonisamide-13C2,15N
An internal standard for the quantification of zonisamide
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GC43874
Hydroflumethiazide
A thiazide diuretic
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GC34186
2-Aminobenzenesulfonamide (Orthanilamide)
2-Aminobenzenesulfonamide (Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide) is an inhibitor of carbonic anhydrase IX.
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GC33491
Acetazolamide D3
AcetazolamideD3是Acetazolamide氘代化合物标准品。
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GC32634
Benzthiazide
Benzthiazide是一种长效的利尿剂和抗高血压剂。Benzthiazide为碳酸酐酶9(carbonicanhydrase9(CA9))的抑制剂,对CA9,CA2和CA1的Ki值分别为8.0,8.8和10nM。Benzthiazide能够抑制肿瘤细胞增殖。
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GC31710
Ethoxzolamide (Redupresin)
Ethoxzolamide (Redupresin) 是一种碳酸酐酶抑制剂,Ki 为 1 nM。
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GC30899
Sultiame
A pan-CA inhibitor and an anticonvulsant
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GC18271
Polmacoxib
An inhibitor of COX-2 and carbonic anhydrase
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GC17003
Benzenesulfonamide
carbonic anhydrase inhibitor
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GC11567
Acetazolamide
An Analytical Reference Standard
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GC14046
Methyclothiazide
A thiazide diuretic
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GC12992
Fluorometholone Acetate
A synthetic glucocorticoid
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GC13932
Dorzolamide
An Analytical Reference Standard
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GC17454
Dichlorphenamide
A carbonic anhydrase inhibitor
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GC14226
Methazolamide
A carbonic anhydrase inhibitor
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GC15158
Tioxolone
A carbonic anhydrase I inhibitor
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GC16149
Topiramate
An anticonvulsant
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GC10737
Brinzolamide
A potent carbonic anhydrase inhibitor
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GC17378
U-104
A carbonic anhydrase inhibitor
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GC17748
Dorzolamide HCl
A carbonic anhydrase inhibitor
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GN10531
Dimethylfraxetin
A coumarin with anti-inflammatory activity