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Indisulam

(Synonyms: N-(3-氯-1H-吲哚-7-基)-1,4-苯二磺酰胺,E 7070) 目录号 : GC65549

A sulfonamide with anticancer activity

Indisulam Chemical Structure

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥693.00
现货
5mg
¥630.00
现货
10mg
¥900.00
现货
25mg
¥1,440.00
现货
50mg
¥2,250.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Indisulam is a sulfonamide with anticancer activity.1 In vitro, indisulam has antiproliferative effects on a wide range of human tumor lines with HCT116 colorectal being the most sensitive and NCI-H596 non-small cell lung cancer (NSCLC) the most resistant (IC50s = 0.11 and 94 μg/ml, respectively). It increases the number of P388 murine leukemia cells in the G1 phase of the cell cycle in a dose-dependent manner and exerts time-dependent cytotoxicity against HCT116 cells. In vivo, indisulam suppresses tumor growth and decreases tumor volume in murine HCT116, SW620, and HCT15 colorectal and LX-1 and PC9 lung cancer xenograft models. Indisulam induces proteasomal degradation of RNA binding motif protein 39 (RBM39) through association with the CUL4-DCAF15 E3 ubiquitin ligase in vitro.2 It is also an inhibitor of carbonic anhydrase in H. pylori (Ki = 310-562 nM).3

1.Ozawa, Y., Sugi, N.H., Nagasu, T., et al.E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivoEur. J. Cancer37(17)2275-2282(2001) 2.Han, T., Goralski, M., Gaskill, N., et al.Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15Science356(6336)(2017) 3.Nishimori, I., Vullo, D., Minakuchi, T., et al.Carbonic anhydrase inhibitors: Cloning and sulfonamide inhibition studies of a carboxyterminal truncated α-carbonic anhydrase from Helicobacter pyloriBioorg. Med. Chem. Lett.16(8)2182-2188(2006)

Chemical Properties

Cas No. 165668-41-7 SDF Download SDF
别名 N-(3-氯-1H-吲哚-7-基)-1,4-苯二磺酰胺,E 7070
分子式 C14H12ClN3O4S2 分子量 385.85
溶解度 DMSO : 100 mg/mL (259.17 mM; Need ultrasonic) 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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