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Fatty acid amide hydrolase (FAAH), belonging to an amidase-signature (AS) protein family, is a membrane-bound protein predominantly in microsomal and mitochondrial fractions that catalyzes the hydrolysis of several bioactive lipids, including anandamide, 2-arachidonoylglycerol (2-AG) and oleamide. The mammalian FAAHs are 63 kDa (579 amino acids in length) proteins characterized by containing several domains defined by homology and function, including, a highly conserved seine-and-glycine-rich AS domain, a predicted transmembrane domain and a proline rich domain. Results of mutation studies suggest, unlike other members of AS protein family, the catalytic activity of FAAH is not associated with the Ser-His-Asp triad but possibly with Ser217 and Lys142.

  1. Cat.No. 产品名称 Information
  2. GC63641 SSR411298
  3. GC36879 PF-04457845 A selective FAAH inhibitor
  4. GC36703 N-Benzyloleamide
  5. GC36671 N-Benzyllinolenamide
  6. GC36023 FAAH inhibitor 1
  7. GC35068 1-Monomyristin A monoacylglycerol
  8. GC31239 SA72
  9. GC30751 FAAH-IN-1
  10. GC30366 FAAH-IN-2
  11. GC18174 BIA 10-2474 An inhibitor of FAAH
  12. GC13963 Oleyl Trifluoromethyl Ketone An analog of oleic acid
  13. GC12031 Monoacylglycerol Lipase Inhibitor 21 A reversible blocker of 2-AG hydrolysis
  14. GC13063 N-Benzylpalmitamide A long-chain fatty acid amide
  15. GC13953 Methyl α-Linolenyl Fluorophosphonate A phospholipase inhibitor
  16. GC12546 JP83 A potent, irreversible FAAH inhibitor
  17. GC15210 PF-622 A selective, potent FAAH inhibitor
  18. GC17159 4-(n-nonyl) Benzeneboronic Acid Potent inhibitor of FAAH
  19. GC15231 Oleoyl Ethyl Amide An endocannabinoid analog that inhibits FAAH and has analgesic activity
  20. GC10133 JNJ-42165279 An irreversible FAAH inhibitor
  21. GC16033 TAK 21d TAK 21d (compound 21d) 是一种有效的、具有口服活性并能穿过血脑屏障脂肪酸酰胺水解酶 (FAAH) 的抑制剂,对 hFAAH 和 rFAAH 的 IC50 分别为 0.72 和 0.28 nM。
  22. GC15077 SA 47 SA 47 是一种选择性强效的脂肪酸酰胺水解酶 (FAAH) 和氨基甲酸酯抑制剂 。
  23. GC17855 SA 57 An inhibitor of FAAH, MAGL, and ABHD6
  24. GC11290 TC-F 2 TC-F 2 是脂肪酸酰胺水解酶 (FAAH) 的可逆非共价结合抑制剂,IC50 为 28 nM。
  25. GC12693 JZL 195 A potent inhibitor of both FAAH and MAGL
  26. GC15358 PF 750 A selective, potent FAAH inhibitor
  27. GC17341 Carprofen An NSAID used in animals
  28. GC15094 LY2183240 A potent, competitive inhibitor of anandamide uptake
  29. GC16984 PF-3845 Inhibitor of FAAH
  30. GC15951 URB597 An inhibitor of FAAH
  31. GC14581 JNJ-1661010 A selective FAAH inhibitor
  32. GN10618 Biochanin A A phytoestrogen

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