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Oleyl Trifluoromethyl Ketone Sale

(Synonyms: Heptadecyl Trifluoromethyl Ketone,OTK) 目录号 : GC13963

An analog of oleic acid

Oleyl Trifluoromethyl Ketone Chemical Structure

Cas No.:177987-23-4

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1mg
¥174.00
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50mg
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Oleyl Trifluoromethyl Ketone is a potent FAAH inhibitor [1][2].

Fatty acid amide hydrolase (FAAH) is a member of the serine hydrolase family of enzymes. FAAH is the principal catabolic enzyme for the fatty acid amides (FAAs) that hydrolyzes both oleamide and anandamide as well as several other fatty acid amides [2].

Oleyl Trifluoromethyl Ketone is an analog of oleic acid in which the COOH group is replaced by trifluoromethyl ketone. Oleyl Trifluoromethyl Ketone is a potent FAAH inhibitor in both human and rat. In transfected COS-7 cells, 10 μM oleyl trifluoromethyl ketone inhibited hydrolysis of oleamide by human and rat FAAH activities by 95.7% and 94.8%, respectively [2].

References:
[1].  Cravatt BF, Giang DK, Mayfield SP, et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature. 1996 Nov 7;384(6604):83-7.
[2].  Giang DK, Cravatt BF. Molecular characterization of human and mouse fatty acid amide hydrolases. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2238-42.

Chemical Properties

Cas No. 177987-23-4 SDF
别名 Heptadecyl Trifluoromethyl Ketone,OTK
化学名 1,1,1-trifluoro-10Z-nonadecen-2-one
Canonical SMILES CCCCCCCC/C=C\CCCCCCCC(=O)C(F)(F)F
分子式 C19H33F3O 分子量 334.5
溶解度 ≤25mg/ml in DMSO;25mg/ml in dimethyl formamide 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.9895 mL 14.9477 mL 29.8954 mL
5 mM 0.5979 mL 2.9895 mL 5.9791 mL
10 mM 0.299 mL 1.4948 mL 2.9895 mL
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