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Rabeprazole sodium Sale

(Synonyms: 雷贝拉唑钠; LY307640 sodium) 目录号 : GC15670

A proton pump inhibitor

Rabeprazole sodium Chemical Structure

Cas No.:117976-90-6

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥368.00
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10mg
¥378.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Rabeprazole sodium(LY307640 sodium) is an antiulcer drug in the class of proton pump inhibitors.Target: Proton PumpRabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. When studied in vitro, rabeprazole is chemically activated at pH 1.2 with a half-life of 78 seconds.

References:
[1]. http://www.drugbank.ca/drugs/DB01129

Chemical Properties

Cas No. 117976-90-6 SDF
别名 雷贝拉唑钠; LY307640 sodium
化学名 sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide
Canonical SMILES CC(C(OCCCOC)=CC=N1)=C1CS(C2=NC3=CC=CC=C3[N-]2)=O.[Na+]
分子式 C18H20N3NaO3S 分子量 381.42
溶解度 ≥ 15.5mg/mL in DMSO 储存条件 Store at -20°C, stored under nitrogen
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.6218 mL 13.1089 mL 26.2178 mL
5 mM 0.5244 mL 2.6218 mL 5.2436 mL
10 mM 0.2622 mL 1.3109 mL 2.6218 mL
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