Dopamine β-hydroxylase(多巴胺β-羟化酶)

DBH (Dopamine-β-hydroxylase) is a copper-containing monooxygenase that catalyzes the biosynthesis of catecholamine neurotransmitter, norepinephrine from dopamine. Deficiency in DBH causes orthostatic hypotension, autonomic disorders etc.

Cat.No. 产品名称 Information
GC60519 4-Hydroxyderricin 4-Hydroxyderricin(4-HD), the major active ingredients of Angelica keiskei Koidzumi, is a potent selective monoamine oxidase (MAO) inhibitor with mild inhibitory effect on dopamine β-hydroxylase.
GC36722 Nepicastat An inhibitor of dopamine β-hydroxylase
GC32593 Zamicastat (BIA 5-1058) Zamicastat (BIA 5-1058) (BIA 5-1058) 是一种多巴胺 β-羟化酶 (DBH) 抑制剂，可穿过血脑屏障 (BBB) 引起中枢和外周效应。
GC32575 Etamicastat (BIA 5-453) Etamicastat (BIA 5-453) (BIA 5-453) 是一种有效且可逆的多巴胺-β-羟化酶 (DBH) 抑制剂，IC50 值为 107 nM。
GC18061 Fusaric Acid A mycotoxin
GC10718 PF 915275 PF 915275 是一种有效的、选择性的、具有口服活性的人 11β-羟基类固醇脱氢酶 1 型 (11βHSD1) 抑制剂，Ki 为 2.3 nM，EC50 为 15 nM（在 HEK293 细胞中）。
GC15558 Mildronate An inhibitor of carnitine biosynthesis
GC12596 Nepicastat (SYN-117) HCl An inhibitor of dopamine β-hydroxylase
GC15382 Isotretinoin A retinoid
GC10801 Disulfiram An irreversible inhibitor of aldehyde dehydrogenase