Dopamine β-hydroxylase(多巴胺β-羟化酶)

DBH (Dopamine-β-hydroxylase) is a copper-containing monooxygenase that catalyzes the biosynthesis of catecholamine neurotransmitter, norepinephrine from dopamine. Deficiency in DBH causes orthostatic hypotension, autonomic disorders etc.

Products for Dopamine β-hydroxylase

Cat.No. 产品名称 Information
GC60519 4-Hydroxyderricin
4-羟基德里辛
4-Hydroxyderricin(4-HD), the major active ingredients of Angelica keiskei Koidzumi, is a potent selective monoamine oxidase (MAO) inhibitor with mild inhibitory effect on dopamine β-hydroxylase.
GC36722 Nepicastat
SYN117; RS-25560-197
An inhibitor of dopamine β-hydroxylase
GC32593 Zamicastat (BIA 5-1058)
BIA 5-1058
Zamicastat (BIA 5-1058) (BIA 5-1058) 是一种多巴胺 β-羟化酶 (DBH) 抑制剂，可穿过血脑屏障 (BBB) 引起中枢和外周效应。
GC32575 Etamicastat (BIA 5-453)
(R)-5-(2-氨基乙基)-1-(6,8-二氟苯并二氢吡喃-3-基)-1,3-二氢咪唑-2-硫酮,BIA 5-453
Etamicastat (BIA 5-453) (BIA 5-453) 是一种有效且可逆的多巴胺-β-羟化酶 (DBH) 抑制剂，IC50 值为 107 nM。
GC18061 Fusaric Acid
萎蔫酸
A mycotoxin
GC10718 PF 915275 PF 915275 是一种有效的、选择性的、具有口服活性的人 11β-羟基类固醇脱氢酶 1 型 (11βHSD1) 抑制剂，Ki 为 2.3 nM，EC50 为 15 nM（在 HEK293 细胞中）。
GC15558 Mildronate
米屈肼,Meldonium; MET-88; Quaterin
An inhibitor of carnitine biosynthesis
GC12596 Nepicastat (SYN-117) HCl
盐酸内匹司他,SYN-117 hydrochloride; RS-25560-197 hydrochloride
An inhibitor of dopamine β-hydroxylase
GC15382 Isotretinoin
异维A酸; 13-cis-Retinoic acid
A retinoid
GC10801 Disulfiram
双硫仑; Tetraethylthiuram disulfide; TETD
An irreversible inhibitor of aldehyde dehydrogenase