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Dopamine β-hydroxylase(多巴胺β-羟化酶)

DBH (Dopamine-β-hydroxylase) is a copper-containing monooxygenase that catalyzes the biosynthesis of catecholamine neurotransmitter, norepinephrine from dopamine. Deficiency in DBH causes orthostatic hypotension, autonomic disorders etc.

  1. Cat.No. 产品名称 Information
  2. GC60519 4-Hydroxyderricin 4-Hydroxyderricin(4-HD), the major active ingredients of Angelica keiskei Koidzumi, is a potent selective monoamine oxidase (MAO) inhibitor with mild inhibitory effect on dopamine β-hydroxylase.
  3. GC36722 Nepicastat An inhibitor of dopamine β-hydroxylase
  4. GC32593 Zamicastat (BIA 5-1058) Zamicastat (BIA 5-1058) (BIA 5-1058) 是一种多巴胺 β-羟化酶 (DBH) 抑制剂,可穿过血脑屏障 (BBB) 引起中枢和外周效应。
  5. GC32575 Etamicastat (BIA 5-453) Etamicastat (BIA 5-453) (BIA 5-453) 是一种有效且可逆的多巴胺-β-羟化酶 (DBH) 抑制剂,IC50 值为 107 nM。
  6. GC18061 Fusaric Acid A mycotoxin
  7. GC10718 PF 915275 PF 915275 是一种有效的、选择性的、具有口服活性的人 11β-羟基类固醇脱氢酶 1 型 (11βHSD1) 抑制剂,Ki 为 2.3 nM,EC50 为 15 nM(在 HEK293 细胞中)。
  8. GC15558 Mildronate An inhibitor of carnitine biosynthesis
  9. GC12596 Nepicastat (SYN-117) HCl An inhibitor of dopamine β-hydroxylase
  10. GC15382 Isotretinoin A retinoid
  11. GC10801 Disulfiram An irreversible inhibitor of aldehyde dehydrogenase

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