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Acyl-CoA: diacylglycerol acyltransferase (DGAT) is an enzyme involved in the biosynthesis of triacylglycerol (TG) that catalyze the final step in the sn-glycerol-3-phosphate (G3P) pathway esterifying diacylglycerol (DG) to produce TG. With the development of techniques in genomics, bioinformatics, transgenics and protein purification, genes encoding two major types of DGAT have been identified, DGAT1 (10.62 kb with 17 exons) and DGAT2 (42.03 kb with 8 exons), which encode two DGAT enzymes with approximately 35% difference in length. Although the two DGAT enzymes have no sequence homology, they exhibit similar activities in the biosynthesis of TG. However, DGAT2 enzyme appears to be a more potent DGAT with a higher affinity towards its substrates than DGAT1 enzyme.

  1. Cat.No. 产品名称 Information
  2. GC50285 JNJ DGAT2-A JNJ DGAT2-A 是一种选择性二酰基甘油酰基转移酶 2 (DGAT2) 抑制剂,在表达人 DGAT2 的 Sf9 昆虫细胞膜中的 IC50 值为 0.14 μM。
  3. GC17013 Amidepsine D Amidepsine D 是一种真菌代谢物,从 Humicola sp. 的培养液中分离出来。
  4. GC11675 Amidepsine A Amidepsine A 是一种真菌代谢物,从 Humicola sp. 的培养液中分离出来。
  5. GC16257 AZD 3988 AZD 3988 是一种具有口服活性的 diacylglycerol acyl transferase-1 (DGAT-1) 抑制剂。
  6. GC11036 LCQ-908 LCQ-908 (LCQ-908) 是一种有效的、选择性的和具有口服活性的二酰基甘油酰基转移酶 1 (DGAT1) 抑制剂。
  7. GC16133 DGAT-1 inhibitor DGAT-1 inhibitor 是一种具有口服活性、选择性和强效的 DGAT1(Acyl-CoA:二酰基甘油酰基转移酶 1)抑制剂,可与 DGAT1 的酰基-CoA 结合位点相互作用,并抑制细胞中三酰基甘油的合成。
  8. GC11475 AZD7687 AZD7687 是一种有效的、选择性的、可逆的和具有口服活性的 diacylglycerol acyltransferase 1 (DGAT1) 抑制剂,对人 DGAT1 的 IC50 为 80 nM。

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