Ferroptosis(铁死亡)
Ferroptosis is a unique iron-dependent form of nonapoptotic cell death. It is triggered by oncogenic RAS-selective lethal small molecule erastin. Acitvation of ferroptosis lead to nonapoptotic destruction of cancer cells.
- Cat.No. 产品名称 Information
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GC70157
YL-939
YL-939 是一种有效的铁死亡 (ferroptosis) 抑制剂。 YL-939 通过靶向 PHB2/铁蛋白/铁轴来抑制铁死亡。
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GC68580
84-B10
84-B10 是一种 3-苯基戊二酸衍生物。84-B10 抑制 cisplatin 诱导的肾小管铁死亡。84-B10 减轻 cisplatin 诱导的线粒体损伤和氧化应激。84-B10 改善 cisplatin 诱导的急性肾损伤 (AKI)。
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GC68479
MMRi62
MMRi62 是一种铁死亡 (Ferroptosis) 诱导剂,靶向 MDM2-MDM4 (抑癌基因 p53 负调控因子)。MMRi62 对胰腺导管腺癌 (PDAC) 细胞显示出 p53 独立的促凋亡 (Apoptosis) 活性,并诱导其自噬 (Autophagy)。MMRi62 诱导铁死亡,伴随着活性氧增加和铁蛋白重链 (FTH1) 溶酶体降解。MMRi62 还可导致突变型 p53 的蛋白酶体降解,并对具有 KRAS 和 TP53 高频突变特征的原位异种移植 PDAC 小鼠模型具有体内药效。
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GC52467
Cell Death Screening Library
For screening a variety of cell death pathways
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GC52413
5-Aminosalicylic Acid-d7
An internal standard for the quantification of 5-aminosalicylic acid
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GC52317
BCP-T.A.
A ferroptosis inducer
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GC52290
(R)-HTS-3
An inhibitor of LPCAT3
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GC52190
Imidazole Ketone Erastin
A ferroptosis inducer
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GC52164
Cu-ATSP
A copper-containing bis(thiosemicarbazone) complex
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GC65163
Ardisiacrispin B
Ardisiacrispin B在多因素耐药癌细胞中显示细胞毒性作用,通过铁中毒和凋亡细胞死亡。
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GC65095
L-Glutamic acid-d5
L-Glutamic acid-d5 是 L-Glutamic acid 的氘代物。L-Glutamic acid 作为一种兴奋性氨基酸神经递质,为谷氨酸盐受体所有亚型(代谢型红藻氨酸、NMDA 和 AMPA)的激动剂。对 DA 从多巴胺能神经末梢释放的过程有激动作用。
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GC65068
L-Glutamine 15N
L-Glutamine-15N (L-Glutamic acid 5-amide-15N) 是 15N 标记的 L-Glutamine。L-Glutamine (L-Glutamic acid 5-amide) 是在人体中大量存在且参与许多代谢过程的非必需氨基酸。L-Glutamine 为某些细胞中的氧化提供了碳源。
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GC49868
D-α-Tocopheryl Quinone
An oxidative metabolite of vitamin E
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GC64352
L-Glutamic acid-15N
L-Glutamic acid-15N 是一种 15N 标记的 L-Glutamic acid。L-Glutamic acid 作为一种兴奋性氨基酸神经递质,为谷氨酸盐受体所有亚型(代谢型红藻氨酸、NMDA 和 AMPA)的激动剂。对 DA 从多巴胺能神经末梢释放的过程有激动作用。
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GC49730
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11
An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE
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GC49697
GPX4 Inhibitor 26a
A GPX4 inhibitor
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GC49691
PSP
A two-photon fluorescent probe for H2Sn
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GC49560
L6H21
An inhibitor of the MD-2 and TLR4 interaction
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GC49454
Complex 3
A fluorescent copper complex with anticancer activity
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GC49308
Ungeremine
A betaine-type alkaloid with diverse biological activities
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GC49058
DTPA
A cell-impermeable metal chelating agent
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GC49034
1(R)-(Trifluoromethyl)oleyl alcohol
An oleic acid analog
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GC62643
L-Buthionine-(S,R)-sulfoximine hydrochloride
An irreversible inhibitor of the γ-glutamylcysteine synthetase
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GC61895
Ammonium iron(III) citrate
Ammonium ferric citrate (Ferric ammonium citrate, Ammonium iron(III) citrate, Iron ammonium citrate, FerriSeltz) induces ferroptosis in non-small-cell lung carcinoma through the inhibition of GPX4-GSS/GSR-GGT axis activity.
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GC61436
Gallic acid hydrate
A phenol with diverse biological activities
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GC48954
CP21
An iron chelator
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GC48650
DTUN
A lipophilic hyponitrite radical initiator
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GC48059
Rosiglitazone-d3
An internal standard for the quantification of rosiglitazone
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GC48030
RC574
An inhibitor of ferroptosis
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GC48029
RC363
An inhibitor of ferroptosis
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GC47870
Pantothenate Kinase Inhibitor
A reversible inhibitor of pantothenate kinase
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GC47478
JKE-1716
A GPX4 inhibitor
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GC47477
JKE-1674
A GPX4 inhibitor and active metabolite of ML-210
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GC47123
Coumarin-Quinone Conjugate
A fluorescent substrate for NADH:ubiquinone oxidoreductases
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GC47065
CAY10773
A derivative of sorafenib
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GC46352
(S)-DO271
An inactive control for DO264
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GC61187
Pioglitazone D4
An internal standard for the quantification of pioglitazone
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GC50345
Liproxstatin-1 hydrochloride
A ferroptosis inhibitor
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GC45995
DO264
An ABHD12 inhibitor
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GC45928
iFSP1
An inhibitor of AIFM2/FSP1
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GC45793
IM-93
A dual inhibitor of ferroptosis and NETosis
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GC45792
Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)
An inducer of ferroptosis
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GC38429
Dihydroartemisinic acid
A precursor to artemisinin
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GC37665
Sorafenib (D4)
Sorafenib D4 (Bay 43-9006 D4) 是 Sorafenib 氘代化合物标准品。Sorafenib 是一种多激酶抑制剂,抑制 Raf-1,B-Raf 和 VEGFR-3 的 IC50 分别为6 nM,20 nM,22 nM。
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GC37664
Sorafenib (D3)
An internal standard for the quantification of sorafenib
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GC36926
Piperazine Erastin
A ferroptosis inducer
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GC36011
Ethylenediaminetetraacetic acid trisodium salt
Ethylenediaminetetraacetic acid (EDTA) is a chelating agent commonly used in protein purification, both to eliminate contaminating divalent cations and to inhibit protease activity.
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GC35876
DL-Glutamine
DL-Glutamine (Glutamin, 2-amino-4-carbamoylbutanoic acid) is a non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes.
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GC35795
D,L-Buthionine-(S,R)-sulfoximine hydrochloride
A γ-glutamylcysteine synthetase inhibitor
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GC35692
Chrysosplenetin
A flavonoid with diverse biological activities