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Home >> Signaling Pathways >> Metabolism >> Ferroptosis

Ferroptosis(铁死亡)

Ferroptosis is a unique iron-dependent form of nonapoptotic cell death. It is triggered by oncogenic RAS-selective lethal small molecule erastin. Acitvation of ferroptosis lead to nonapoptotic destruction of cancer cells.

  1. Cat.No. 产品名称 Information
  2. GC70157 YL-939 YL-939 是一种有效的铁死亡 (ferroptosis) 抑制剂。 YL-939 通过靶向 PHB2/铁蛋白/铁轴来抑制铁死亡。
  3. GC68580 84-B10 84-B10 是一种 3-苯基戊二酸衍生物。84-B10 抑制 cisplatin 诱导的肾小管铁死亡。84-B10 减轻 cisplatin 诱导的线粒体损伤和氧化应激。84-B10 改善 cisplatin 诱导的急性肾损伤 (AKI)。
  4. GC68479 MMRi62

    MMRi62 是一种铁死亡 (Ferroptosis) 诱导剂，靶向 MDM2-MDM4 (抑癌基因 p53 负调控因子)。MMRi62 对胰腺导管腺癌 (PDAC) 细胞显示出 p53 独立的促凋亡 (Apoptosis) 活性，并诱导其自噬 (Autophagy)。MMRi62 诱导铁死亡，伴随着活性氧增加和铁蛋白重链 (FTH1) 溶酶体降解。MMRi62 还可导致突变型 p53 的蛋白酶体降解，并对具有 KRAS 和 TP53 高频突变特征的原位异种移植 PDAC 小鼠模型具有体内药效。
  5. GC52467 Cell Death Screening Library For screening a variety of cell death pathways
  6. GC52413 5-Aminosalicylic Acid-d7 An internal standard for the quantification of 5-aminosalicylic acid
  7. GC52317 BCP-T.A. A ferroptosis inducer
  8. GC52290 (R)-HTS-3 An inhibitor of LPCAT3
  9. GC52190 Imidazole Ketone Erastin A ferroptosis inducer
  10. GC52164 Cu-ATSP A copper-containing bis(thiosemicarbazone) complex
  11. GC65163 Ardisiacrispin B Ardisiacrispin B在多因素耐药癌细胞中显示细胞毒性作用，通过铁中毒和凋亡细胞死亡。
  12. GC65095 L-Glutamic acid-d5 L-Glutamic acid-d5 是 L-Glutamic acid 的氘代物。L-Glutamic acid 作为一种兴奋性氨基酸神经递质，为谷氨酸盐受体所有亚型(代谢型红藻氨酸、NMDA 和 AMPA)的激动剂。对 DA 从多巴胺能神经末梢释放的过程有激动作用。
  13. GC65068 L-Glutamine 15N L-Glutamine-15N (L-Glutamic acid 5-amide-15N) 是 15N 标记的 L-Glutamine。L-Glutamine (L-Glutamic acid 5-amide) 是在人体中大量存在且参与许多代谢过程的非必需氨基酸。L-Glutamine 为某些细胞中的氧化提供了碳源。
  14. GC49868 D-α-Tocopheryl Quinone An oxidative metabolite of vitamin E
  15. GC64352 L-Glutamic acid-15N L-Glutamic acid-15N 是一种 15N 标记的 L-Glutamic acid。L-Glutamic acid 作为一种兴奋性氨基酸神经递质，为谷氨酸盐受体所有亚型(代谢型红藻氨酸、NMDA 和 AMPA)的激动剂。对 DA 从多巴胺能神经末梢释放的过程有激动作用。
  16. GC49730 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11 An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE
  17. GC49697 GPX4 Inhibitor 26a A GPX4 inhibitor
  18. GC49691 PSP A two-photon fluorescent probe for H2Sn
  19. GC49560 L6H21 An inhibitor of the MD-2 and TLR4 interaction
  20. GC49454 Complex 3 A fluorescent copper complex with anticancer activity
  21. GC49308 Ungeremine A betaine-type alkaloid with diverse biological activities
  22. GC49058 DTPA A cell-impermeable metal chelating agent
  23. GC49034 1(R)-(Trifluoromethyl)oleyl alcohol An oleic acid analog
  24. GC62643 L-Buthionine-(S,R)-sulfoximine hydrochloride An irreversible inhibitor of the γ-glutamylcysteine synthetase
  25. GC61895 Ammonium iron(III) citrate Ammonium ferric citrate (Ferric ammonium citrate, Ammonium iron(III) citrate, Iron ammonium citrate, FerriSeltz) induces ferroptosis in non-small-cell lung carcinoma through the inhibition of GPX4-GSS/GSR-GGT axis activity.
  26. GC61436 Gallic acid hydrate A phenol with diverse biological activities
  27. GC48954 CP21 An iron chelator
  28. GC48650 DTUN A lipophilic hyponitrite radical initiator
  29. GC48059 Rosiglitazone-d3 An internal standard for the quantification of rosiglitazone
  30. GC48030 RC574

    An inhibitor of ferroptosis
  31. GC48029 RC363 An inhibitor of ferroptosis
  32. GC47870 Pantothenate Kinase Inhibitor A reversible inhibitor of pantothenate kinase
  33. GC47478 JKE-1716 A GPX4 inhibitor
  34. GC47477 JKE-1674 A GPX4 inhibitor and active metabolite of ML-210
  35. GC47123 Coumarin-Quinone Conjugate A fluorescent substrate for NADH:ubiquinone oxidoreductases
  36. GC47065 CAY10773 A derivative of sorafenib
  37. GC46352 (S)-DO271 An inactive control for DO264
  38. GC61187 Pioglitazone D4 An internal standard for the quantification of pioglitazone
  39. GC50345 Liproxstatin-1 hydrochloride A ferroptosis inhibitor
  40. GC45995 DO264 An ABHD12 inhibitor
  41. GC45928 iFSP1 An inhibitor of AIFM2/FSP1
  42. GC45793 IM-93 A dual inhibitor of ferroptosis and NETosis
  43. GC45792 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) An inducer of ferroptosis
  44. GC38429 Dihydroartemisinic acid A precursor to artemisinin
  45. GC37665 Sorafenib (D4) Sorafenib D4 (Bay 43-9006 D4) 是 Sorafenib 氘代化合物标准品。Sorafenib 是一种多激酶抑制剂，抑制 Raf-1，B-Raf 和 VEGFR-3 的 IC50 分别为6 nM，20 nM，22 nM。
  46. GC37664 Sorafenib (D3) An internal standard for the quantification of sorafenib
  47. GC36926 Piperazine Erastin A ferroptosis inducer
  48. GC36011 Ethylenediaminetetraacetic acid trisodium salt Ethylenediaminetetraacetic acid (EDTA) is a chelating agent commonly used in protein purification, both to eliminate contaminating divalent cations and to inhibit protease activity.
  49. GC35876 DL-Glutamine DL-Glutamine (Glutamin, 2-amino-4-carbamoylbutanoic acid) is a non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes.
  50. GC35795 D,L-Buthionine-(S,R)-sulfoximine hydrochloride A γ-glutamylcysteine synthetase inhibitor
  51. GC35692 Chrysosplenetin A flavonoid with diverse biological activities

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