Pentetic acid (DTPA)
(Synonyms: 二乙烯三胺五醋酸,Diethylenetriaminepentaacetic acid; DTPA) 目录号 : GC49058
Pentetic acid (DTPA)是一种强效氨基多羧酸螯合剂，其结构与EDTA相似。
Cas No.:67-43-6
Sample solution is provided at 25 µL, 10mM.
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Pentetic acid (DTPA) is a powerful aminopolycarboxylic acid chelating agent with a structure similar to EDTA [1]. Pentetic acid binds tightly to metal ions, forming stable complexes that are rapidly excreted through urine, thereby reducing the retention and toxicity of harmful metals in the body [2]. Pentetic acid is primarily used in the treatment of radioactive contamination and as an imaging agent in medical imaging [3-4].
In PAO1 bacterial, Pentetic acid can significantly inhibit the secretion of elastase [5].
References:
[1]. Knepper T P. Synthetic chelating agents and compounds exhibiting complexing properties in the aquatic environment[J]. TrAC Trends in Analytical Chemistry, 2003, 22(10): 708-724.
[2]. Sandal N, Mahar R, Sharma P. Optimizing Ca-DTPA/Zn-DTPA therapy for internal decorporation: transitioning from intravenous to oral route with insights on safety and toxicity[J]. Journal of Radiological Protection, 2025, 45(1): 011002.
[3]. Hussain A, Alajmi M F, Ganguly S. Pentetic acid derived dual purpose fluorescent carbon dots for pH responsive drug delivery and antioxidant proficiency[J]. Diamond and Related Materials, 2024, 145: 111101.
[4]. Capra R, Marcianò N, Vignolo L A, et al. Gadolinium—Pentetic Acid Magnetic Resonance Imaging in Patients With Relapsing Remitting Multiple Sclerosis[J]. Archives of neurology, 1992, 49(7): 687-689.
[5]. Gi M, Jeong J, Lee K, et al. A drug-repositioning screening identifies pentetic acid as a potential therapeutic agent for suppressing the elastase-mediated virulence of Pseudomonas aeruginosa[J]. Antimicrobial agents and chemotherapy, 2014, 58(12): 7205-7214.
Pentetic acid (DTPA)是一种强效氨基多羧酸螯合剂，其结构与EDTA相似 [1]。Pentetic acid能与金属离子紧密结合，形成稳定的复合物，并迅速通过尿液排出，从而减少有害金属在体内的滞留和毒性 [2]。Pentetic acid主要用于治疗放射性污染，并用作医学影像中的显像剂 [3-4]。
在PAO1细菌中，Pentetic acid能显著抑制弹性蛋白酶的分泌 [5]。
| Antibacterial experiment [1]: | |
Bacterial | PAO1 bacterial |
Preparation Method | PAO1 bacterial cultures were grown in Luria-Bertani (LB) broth (10g tryptone, 5g yeast extract, and 10g sodium chloride per liter) at 37℃. The transcript levels of the rpoD gene were similar in cells grown in plain LB medium and in LB medium supplemented with Pentetic acid or EDTA, which was used for normalization. |
Reaction Conditions | 50μM; 16h |
Applications | Pentetic acid can significantly inhibit the secretion of elastase. |
References: | |
| Cas No. | 67-43-6 | SDF | |
| 别名 | 二乙烯三胺五醋酸,Diethylenetriaminepentaacetic acid; DTPA | ||
| Canonical SMILES | O=C(CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)O | ||
| 分子式 | C14H23N3O10 | 分子量 | 393.4 |
| 溶解度 | Ethanol: slightly soluble,Methanol: slightly soluble,PBS (pH 7.2): slightly soluble | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.5419 mL | 12.7097 mL | 25.4194 mL |
| 5 mM | 0.5084 mL | 2.5419 mL | 5.0839 mL |
| 10 mM | 0.2542 mL | 1.271 mL | 2.5419 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet