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Home >> Signaling Pathways >> Metabolism >> Ferroptosis

Ferroptosis(铁死亡)

Ferroptosis is a unique iron-dependent form of nonapoptotic cell death. It is triggered by oncogenic RAS-selective lethal small molecule erastin. Acitvation of ferroptosis lead to nonapoptotic destruction of cancer cells.

Products for  Ferroptosis

  1. Cat.No. 产品名称 Information
  2. GC17309 Withaferin A A steroidal lactone with diverse biological activities
  3. GC10889 Artesunate An antimalarial compound
  4. GC10451 U-73122

    Inhibits PLC-dependent processes
  5. GC15972 Idebenone An analog of CoQ10 with neuroprotective effects
  6. GC10132 Ciclopirox An iron chelator, antifungal, and anticancer agent
  7. GC18101 Deferiprone An iron chelator
  8. GC11120 Ciclopirox ethanolamine An iron chelator, antifungal, and anticancer agent
  9. GC12698 BAY 87-2243 A mitochondrial complex I inhibitor and inducer of ferroptosis
  10. GC13083 Siramesine A selective σ2 receptor agonist
  11. GC14948 Pioglitazone Pioglitazone (PIO)是一种噻唑烷二酮类抗糖尿病药物,可作为PPARγ激动剂。它对人和小鼠PPARγ的EC50分别为0.93和0.99 µM..
  12. GC15222 Siramesine hydrochloride Siramesine (Lu 28-179) hydrochloride 是一种有效的 sigma-2 受体激动剂。 Siramesine hydrochloride 对 sigma-2 受体具有亚纳摩尔亲和力 (IC50=0.12 nM)，对 sigma-2 受体的选择性是 sigma-1 受体的 140 倍 (IC50=17 nM)。盐酸西拉美新通过破坏线粒体而不是溶酶体触发细胞死亡。抗癌活性。
  13. GC16630 Erastin

    Erastin是一种能够穿透细胞膜的铁死亡激活剂和抗肿瘤药物。
  14. GC10345 Bay 11-7085 An irreversible inhibitor of IκBα phosphorylation
  15. GC11835 Deferasirox An iron chelator with anticancer activity
  16. GC10585 Simvastatin (Zocor) An HMG-CoA reductase inhibitor
  17. GC17498 L-Glutamine A conditionally essential amino acid
  18. GC11786 Acetylcysteine An antioxidant and glutathione precursor
  19. GC11908 Cisplatin

    顺铂是最好的、最早的基于金属的化疗药物之一，用于治疗广泛的实体肿瘤，如睾丸癌、卵巢癌、膀胱癌、肺癌、宫颈癌、头颈部肿瘤、胃癌和其他一些类型的癌症。
  20. GC16014 Zileuton A reversible inhibitor of 5-lipoxygenase
  21. GC16868 Sulfasalazine A prodrug form of 5-aminosalicylic acid
  22. GC13968 SB202190 (FHPI)

    SB 202190 is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively.
  23. GC15344 SP 600125 A pan-JNK inhibitor
  24. GC16499 Sorafenib Tosylate A multi-kinase inhibitor
  25. GC17198 Cycloheximide

    环丙沙星是一种抗生素，它在翻译水平上抑制蛋白质合成。
  26. GC13608 Lapatinib A dual inhibitor of EGFR and ErbB2
  27. GC16593 Lapatinib Ditosylate Lapatinib Ditosylate (GW572016 ditosylate monohydrate) 是有效的 ErbB-2 和 EGFR 酪氨酸激酶结构域抑制剂，对纯化的 EGFR 和 ErbB-2 的 IC50 值分别为 10.2 和 9.8 nM。
  28. GC11247 PRIMA-1MET A re-activator of the apoptotic function of mutant p53 proteins
  29. GC10896 Cyclic Pifithrin-α hydrobromide A stable inhibitor of p53
  30. GC12086 PRIMA-1 A re-activator of the apoptotic function of mutant p53 proteins
  31. GC10282 Piperlongumine An alkaloid with anticancer and antioxidant activities
  32. GC15272 Troglitazone Selective PPARγ agonist
  33. GC18089 Nordihydroguaiaretic acid A non-selective LO inhibitor
  34. GC17412 Deferasirox Fe3+ chelate Deferasirox Fe3+ Chelate 是从专利 WO2003053986 中提取的铁螯合剂。
  35. GC14787 Curcumin A yellow pigment with diverse biological activities
  36. GC11572 Bardoxolone methyl A synthetic triterpenoid with potent anticancer and antidiabetic activity
  37. GC10380 Ferrostatin-1 (Fer-1)

    一种铁死亡抑制剂
  38. GC14538 Pravastatin sodium A potent HMG-CoA reductase inhibitor
  39. GC14038 Atorvastatin Calcium An HMG-CoA reductase inhibitor
  40. GC11633 Lovastatin An inhibitor of HMG-CoA reductase
  41. GC15541 Fluvastatin Sodium An HMG-CoA reductase inhibitor
  42. GC11152 Pioglitazone HCl A PPARγ agonist
  43. GC16444 Rosiglitazone

    A PPARγ agonist
  44. GC11318 Rosiglitazone maleate A PPARγ agonist
  45. GC10538 Pifithrin-α (PFTα) Pifithrin-α(PFT-α)是一种p53抑制剂,在神经科学中广泛用于阻断神经元凋亡细胞死亡, 也可以作为强效的芳烃受体(AhR)刺激物。.
  46. GC11008 Necrostatin-1

    A RIP1 kinase inhibitor
  47. GC15130 Alogliptin (SYR-322) Alogliptin (SYR-322) (SYR-322 free base) 是一种有效的、选择性的、具有口服活性的 DPP-4 抑制剂，IC50 <10 nM，选择性比 DPP-8 和 DPP-9 高 10,000 倍以上.
  48. GC16733 Vildagliptin (LAF-237) A DPP-4 inhibitor
  49. GC14827 Linagliptin (BI-1356) A potent DPP-4 inhibitor
  50. GC13139 FG-4592 (ASP1517) An inhibitor of HIF-PH enzymes
  51. GC17369 Sorafenib

    Sorafenib acts as a multi-kinase inhibitor, targeting Raf-1 and B-Raf with IC50 values of 6 nM and 22 nM, respectively.

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