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Dehydrogenases, belonging to the class of oxidoreductases which catalyze donor-acceptor reactions to transfer electron molecules from the oxidant to the reluctant, are a diverse group of enzymes that are able to transfer one or more hydrides (H-) from a substrate to an electron acceptor, such as nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide phosphate (NADP+) or Riboflavin, through oxidation and reduction. Three commonly studied dehydrogenase enzymes include alcohol dehydrogenase (ADH) which catalyzes the reduction of acetylaldehyde to ethanol in plant cells, succinate dehydrogenase which oxidizes succinate to fumarate, and lactate dehydrogenase which catalyzes the reversible oxidation of lactate to pyruvate.

  1. Cat.No. 产品名称 Information
  2. GP26172 PGD Human, Active PGD Human Recombinant produced in E
  3. GP26169 NQO1 Human, Active NQO1 Human Recombinant produced in E
  4. GP26164 LDHA, E.Coli Active LDHA E
  5. GC25389 Ethyl potassium malonate Ethyl potassium malonate (Potassium 3-ethoxy-3-oxopropanoate) is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation and serves as an intermediate for the preparation of ethyl tert-butyl malonate.
  6. GC25039 AG-120 (racemic) AG-120 (racemic), the racemic mixture of AG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity.
  7. GC50509 PKUMDL WQ 2201 Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
  8. GC50508 PKUMDL WQ 2101 Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)
  9. GC16860 NCT-502 A PHGDH inhibitor
  10. GC13262 A-771726 An active metabolite of leflunomide
  11. GC17293 PHGDH-inactive A negative control for NCT-502 and NCT-503
  12. GC15547 Inosine-5'-monophosphate (sodium salt hydrate) A 5’-ribonucleoside
  13. GC10462 6-Aminonicotinamide Inhibitor of 6-phosphogluconate dehydrogenase
  14. GC15943 NCT-503 A PHGDH inhibitor
  15. GC13776 Piericidin A

    A potent inhibitor of mitochondrial complex I

  16. GC12204 STK393606 A selective inhibitor of 15-PGDH
  17. GC14415 ML390 A DHODH inhibitor
  18. GC15601 AG-120 An IDH1 inhibitor
  19. GC13147 AG-221 (Enasidenib) An inhibitor of mutant IDH2
  20. GC17914 Fomepizole An alcohol dehydrogenase inhibitor
  21. GC11149 L-a-Hydroxyglutaric acid disodium salt An α-hydroxy acid
  22. GC13579 DL-α-Hydroxyglutaric acid disodium salt An α-hydroxy acid
  23. GC15738 BVT 2733 An 11β-HSD1 inhibitor
  24. GC13336 CBR-5884 A selective PHGDH inhibitor
  25. GC13464 GSK 2837808A

    GSK2837808A is a selective inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 2.

  26. GC10902 CVT 10216 A selective, reversible ALDH2 inhibitor
  27. GC16951 Stiripentol An antiepileptic compound
  28. GC15266 Qc 1 Qc 1 是一种可逆的非竞争性苏氨酸脱氢酶 (TDH) 抑制剂。
  29. GC13760 TC HSD 21 An inhibitor of 17β-HSD3
  30. GC16597 Alda 1

    A selective ALDH2 agonist

  31. GC13611 CGP 3466B maleate A GAPDH ligand
  32. GC16816 Galloflavin An inhibitor of lactate dehydrogenase
  33. GC10438 WIN 18446 An inhibitor of aldehyde dehydrogenase 1a2
  34. GC13670 Methylmalonate A dicarboxylic acid and byproduct of propionate catabolism
  35. GC14851 Vidofludimus An immunosuppressive drug that inhibits DHODH
  36. GC14757 AGI-6780 A potent, selective inhibitor of mutant IDH2
  37. GC17107 PluriSIn #1 (NSC 14613) A selective inhibitor of stearoyl-CoA desaturase
  38. GC14783 Trilostane A 3β-hydroxysteroid dehydrogenase inhibitor
  39. GC17467 Gimeracil A DYPD inhibitor
  40. GC10531 AGI-5198 A potent, selective inhibitor of IDH1 mutations
  41. GC13614 Mycophenolate Mofetil A prodrug form of mycophenolic acid
  42. GC14921 CPI-613 An inhibitor of α-ketoglutarate dehydrogenase

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