Dehydrogenase(脱氢酶)
Dehydrogenases, belonging to the class of oxidoreductases which catalyze donor-acceptor reactions to transfer electron molecules from the oxidant to the reluctant, are a diverse group of enzymes that are able to transfer one or more hydrides (H-) from a substrate to an electron acceptor, such as nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide phosphate (NADP+) or Riboflavin, through oxidation and reduction. Three commonly studied dehydrogenase enzymes include alcohol dehydrogenase (ADH) which catalyzes the reduction of acetylaldehyde to ethanol in plant cells, succinate dehydrogenase which oxidizes succinate to fumarate, and lactate dehydrogenase which catalyzes the reversible oxidation of lactate to pyruvate.
Products for Dehydrogenase
- Cat.No. 产品名称 Information
- GP26172 PGD Human, Active PGD Human Recombinant produced in E
- GP26169 NQO1 Human, Active NQO1 Human Recombinant produced in E
- GP26164 LDHA, E.Coli Active LDHA E
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GC25389
Ethyl potassium malonate
Potassium 3-ethoxy-3-oxopropanoate, Malonic Acid Monoethyl Ester Potassium Salt
Ethyl potassium malonate (Potassium 3-ethoxy-3-oxopropanoate) is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation and serves as an intermediate for the preparation of ethyl tert-butyl malonate. - GC25039 AG-120 (racemic) AG-120 (racemic), the racemic mixture of AG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity.
- GC50509 PKUMDL WQ 2201 Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
- GC50508 PKUMDL WQ 2101 Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)
- GC16860 NCT-502 A PHGDH inhibitor
-
GC13262
A-771726
特立氟胺; A77 1726
An active metabolite of leflunomide -
GC17293
PHGDH-inactive
3-Phosphoglycerate Dehydrogenase-inactive
A negative control for NCT-502 and NCT-503 -
GC15547
Inosine-5'-monophosphate (sodium salt hydrate)
肌苷-5′-磷酸二钠盐,IMP,Inosinic Acid
A 5’-ribonucleoside -
GC10462
6-Aminonicotinamide
6-氨基烟酰胺
Inhibitor of 6-phosphogluconate dehydrogenase - GC15943 NCT-503 NCT-503 是一种磷酸甘油酸脱氢酶 (PHGDH) 抑制剂,IC50 为 2.5 μM用 NCT-503 处理三种 PHGDH 非依赖性细胞系和五种 PHGDH 依赖性细胞系表明,NCT-503 对 PHGDH 依赖性细胞系的 EC50 值为 8-16 μM,并且对其他 PHGDH 非依赖性细胞无毒性 行。
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GC13776
Piericidin A
粉蝶霉素A,AR 054, Shaoguanmycin B, SN 198E
A potent inhibitor of mitochondrial complex I
- GC12204 STK393606 A selective inhibitor of 15-PGDH
- GC14415 ML390 A DHODH inhibitor
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GC15601
AG-120
艾伏尼布,AG-120
An IDH1 inhibitor -
GC13147
AG-221 (Enasidenib)
恩西地平; AG-221
An inhibitor of mutant IDH2 -
GC17914
Fomepizole
甲吡唑; 4-Methylpyrazole
An alcohol dehydrogenase inhibitor -
GC11149
L-a-Hydroxyglutaric acid disodium salt
S-2-羟基戊二酸,(S)-2-Hydroxyglutaric acid disodium
An α-hydroxy acid - GC15738 BVT 2733 An 11β-HSD1 inhibitor
- GC13336 CBR-5884 A selective PHGDH inhibitor
- GC13464 GSK 2837808A GSK2837808A 是一种选择性的 LDHA (lactate dehydrogenase A) 的抑制剂,对hLDHA和hLDHB的IC50分别为2.6 nM和43 nM.GSK2837808A(10 µM;24-72h)通过促进有氧糖酵解、增殖、细胞周期和细胞凋亡抵抗,阻断了着丝粒蛋白N (CENP-N)过表达对鼻咽癌细胞的影响。
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GC10902
CVT 10216
3-[[[3-[4-[(甲基磺酰基)氨基]苯基]-4-氧代-4H-苯并吡喃-7-基]氧基]甲基]苯甲酸
A selective, reversible ALDH2 inhibitor -
GC16951
Stiripentol
斯利潘托,BCX2600
An antiepileptic compound - GC15266 Qc 1 Qc 1 是一种可逆的非竞争性苏氨酸脱氢酶 (TDH) 抑制剂。
-
GC13760
TC HSD 21
TC Hydroxysteroid Dehydrogenase 21
An inhibitor of 17β-HSD3 -
GC16597
Alda 1
N-(1,3-苯并二氧杂环戊烯-5-基甲基)-2,6-二氯苯甲酰胺
A selective ALDH2 agonist
-
GC13611
CGP 3466B maleate
CGP3466B maleate
A GAPDH ligand -
GC16816
Galloflavin
培黄素
An inhibitor of lactate dehydrogenase -
GC10438
WIN 18446
N,N'-八亚甲基双二氯乙酰胺
An inhibitor of aldehyde dehydrogenase 1a2 -
GC13670
Methylmalonate
甲基丙二酸; Methylpropanedioic acid; Methylmalonate
A dicarboxylic acid and byproduct of propionate catabolism -
GC14851
Vidofludimus
维多氟拉迪莫,4sc-101; SC12267
An immunosuppressive drug that inhibits DHODH -
GC14757
AGI-6780
AGI 6780;AGI6780
A potent, selective inhibitor of mutant IDH2 -
GC17107
PluriSIn #1 (NSC 14613)
NSC 14613
A selective inhibitor of stearoyl-CoA desaturase -
GC14783
Trilostane
曲洛司坦; Win 24540
A 3β-hydroxysteroid dehydrogenase inhibitor -
GC17467
Gimeracil
吉美嘧啶; Gimestat
A DYPD inhibitor -
GC10531
AGI-5198
AGI5198, AGI 5198
A potent, selective inhibitor of IDH1 mutations -
GC13614
Mycophenolate Mofetil
吗替麦考酚酯; RS 61443; TM-MMF
A prodrug form of mycophenolic acid -
GC14921
CPI-613
6,8-双(苄硫基)辛酸,CPI-613
An inhibitor of α-ketoglutarate dehydrogenase