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6-Aminonicotinamide Sale

(Synonyms: 6-氨基烟酰胺) 目录号 : GC10462

Inhibitor of 6-phosphogluconate dehydrogenase

6-Aminonicotinamide Chemical Structure

Cas No.:329-89-5

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Ki: 0.46 μM

6-Aminonicotinamide is a 6-phosphogluconate dehydrogenase inhibitor.

6-Phosphogluconate dehydrogenase, an enzyme in the pentose phosphate pathway, can produce ribulose 5-phosphate from 6-phosphogluconate. 6-Phosphogluconate dehydrogenase is also an oxidative carboxylase catalyzing the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP.

In vitro: 6-Aminonicotinamide could be metabolized to 6-amino-NAD(P+), a competitive inhibitor of NAD(P+)-requiring processes, especially the pentose phosphate pathway enzyme, 6-phosphogluconate dehydrogenase. Moreove, 6-aminonicotinamide as a single agent could cause a significant inhibition of glycolytic flux but had no effect on the pentose phosphate pathway. 31P-NMR studies of perifused RIF-1 cells indicated that 4 h of exposure to 6-aminonicotinamide was enough to cause significant accumulation of 6-phosphogluconate, the substrate for this enzyme [1].

In vivo: The influence of 6-aminonicotinamide on the G-6-P-DH- and 6-PG-DH-levels of the pentose phosphate pathway in the kidney was investigated. Following i.p. administration of 6-aminonicotinamide at 6 mg/kg, the 6-PG-level rose from a value less than 10 nmoles/g to 1000 nmoles/g fresh weight within 24 h. In addition, at the end of the assay, after 7 days, a 6-PG-concentration of about 150 nmoles/g fresh weight was still seen. Moreove, the G-6-P level simultaneously rose with the 6-PG-level to about 150% of the control level and returned to normal on the 5th day [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Street, J. C.,Alfieri, A.A. and Koutcher, J.A. Quantitation of metabolic and radiobiological effects of 6-aminonicotinamide in RIF-1 tumor cells in vitro. Cancer Research 57, 3956-3962 (1997).
[2] Lange, K.  and Proft, E.R. Inhibition of the 6-phosphogluconate dehydrogenase in the rat kidney by 6-aminonicotinamide. Naunyn-Schmiedeberg's Archives of Pharmacology 267, 177-180 (1970).

Chemical Properties

Cas No. 329-89-5 SDF
别名 6-氨基烟酰胺
化学名 6-amino-3-pyridinecarboxamide
Canonical SMILES Nc1ccc(cn1)C(=O)N
分子式 C6H7N3O 分子量 137.1
溶解度 ≥ 13.7mg/mL in DMSO 储存条件 4°C, protect from light
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1 mM 7.2939 mL 36.4697 mL 72.9395 mL
5 mM 1.4588 mL 7.2939 mL 14.5879 mL
10 mM 0.7294 mL 3.647 mL 7.2939 mL
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