Phospholipase(磷脂酶)
Phospholipases are enzymes that catalyze the hydrolysis of phospholipids into fatty acids and other lipid mediators. It plays a variety of roles in tumorgenesis , inflammation and brain disorders etc.
- Cat.No. 产品名称 Information
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GC69862
SB-435495
SB-435495 是一种有效的、选择性的、可逆的、非共价的、具有口服活性的 Lp-PLA2 抑制剂,IC50 为 0.06 nM。
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GC69371
LFHP-1c
LFHP-1c 是一种 PGAM5 抑制剂,在缺血性脑卒中中具有神经保护活性。LFHP-1c 保护血脑屏障完整性免受缺血损伤。LFHP-1c 与内皮细胞 PGAM5 结合,抑制 PGAM5 磷酸酶活性,抑制 PGAM5 与 NRF2 的相互作用。LFHP-1c 具有体外和体内保护作用。
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GC69136
Fuzapladib sodium
Fuzapladib sodium (IS-741 sodium) 是一种有效的具有口服活性的磷脂酶 A2 (phospholipase A2) 抑制剂。Fuzapladib sodium 可以阻断炎症细胞与微血管内皮细胞的粘附,抑制嗜中性粒细胞浸润到胰腺或急性胰腺炎中,具有抗急性胰腺炎作用。
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GC67909
GSK2647544
GSK2647544 是一种口服的、选择性的 Lp-PLA2 抑制剂。Lp-PLA2是一种钙非依赖性磷脂酶 A2,具有促炎活性,主要由单核细胞衍生的巨噬细胞分泌。
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GC52315
GK241
An sPLA2 (Type IIA) inhibitor
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GC67211
BAPTA tetrapotassium
An extracellular calcium chelator
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GC65595
3-Nitrocoumarin
3-Nitrocoumarin (3-NC) 是一个有效的、磷脂酶 C-γ (PLC-γ) 的选择性抑制剂。
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GC64388
CCT129957
CCT129957 是一种吲哚衍生物,也是一种有效的磷脂酶 C-γ (PLC-γ) 抑制剂,IC50 为 ~3 μM,GC50 为 15 μM。CCT129957 以约 15 μM 的浓度抑制鳞状细胞中 Ca2+ 的释放。
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GC52080
LEI-110
An AdPLA2 inhibitor
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GC49784
AZD 2716
An sPLA2 inhibitor
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GC64306
ROC-0929
ROC-0929 (compound 13a) 是一种有效且选择性的分泌型磷脂酶 A2 (sPLA2s) 抑制剂。其IC50值为 80 nM,特异性靶点为hGX。ROC-0929 抑制 ERK1/2 和 p-38 的磷酸化。分泌型磷脂酶 A2 (sPLA2s) 是富含二硫键的 Ca2+ 依赖性酶家族,可水解甘油磷脂的 sn-2 位以释放脂肪酸和溶血磷脂。ROC-0929具有研究炎症相关疾病的潜力。
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GC64070
Omeprazole-d3-1
An internal standard for the quantification of omeprazole
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GC63860
Rapanone
Rapanone 是一种天然苯醌。Rapanone 具有广泛的生物作用,包括抗肿瘤、抗氧化、抗炎、抗菌和抗寄生虫。Rapanone 还是一种有效和选择性的人滑膜 PLA2 抑制剂,IC50 值为 2.6 μM。
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GC49635
LY433771
An inhibitor of type X sPLA2
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GC49546
Melittin (trifluoroacetate salt)
The principal cytotoxic component of bee venom
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GC49457
Oleoyl-Coenzyme A (sodium salt)
酰基辅酶A硫酯
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GC61689
Alminoprofen
Alminoprofen是苯丙酸类非甾体抗炎药(NSAID)。Alminoprofen同时具有抑制分泌磷脂酶A2(sPLA2)活性和抗环氧化酶(COX-2)的活性。
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GC50738
SGC 3027N
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GC50726
ASB 14780
ASB 14780 是一种 4-苯氧基衍生物,是胞质磷脂酶 A2α (cPLA2α) 抑制剂,IC50 值为 20 nM。
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GC47049
CAY10641
An inactive alcohol derivative of a highly potent cPLA2 inhibitor
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GC46761
9-Oxononanoic Acid
An oxidized fatty acid
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GC46352
(S)-DO271
An inactive control for DO264
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GC61355
Tris(2,4-di-tert-butylphenyl)phosphate
Tris(2,4-di-tert-butylphenyl)phosphate是从VitexnegundoL.中分离的一种活性化合物,具有抗炎活性,并通过分子对接抑制了分泌性磷脂酶A2(sPLA2)。
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GC61344
trans-Benzylideneacetone
Trans-4-Phenyl-3-buten-2-one (trans-Benzylideneacetone, trans-Benzalacetone, trans-Benzylideneacetone) is an inhibitor of the enzyme phospholipase A2 (PLA2). Trans-4-Phenyl-3-buten-2-one is used as a flavouring agent, a fragrance and a bacterial metabolite.
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GC61155
Omeprazole sodium
An irreversible inhibitor of the gastric proton pump
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GC61040
Melittin TFA
Melittin (MLT, Forapin, Forapine) is an activator of phospholipase A2 (PLA2) that stimulates the activity of the low molecular weight PLA2, while it does not the increase the activity of the high molecular weight enzyme.
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GC60982
LEI-401
An NAPE-PLD inhibitor
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GC45995
DO264
An ABHD12 inhibitor
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GC45618
(±)-trans-GK563
A GVIA iPLA2 inhibitor
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GC37674
SPK-601
SPK-601(LMV-601)是卵磷脂特异磷脂酶C(PC-PLC)抑制剂,可用作抗菌剂。
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GC35390
Aristolochic acid C
An alkaloid with anticancer activity
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GC35065
1-Linoleoyl Glycerol
A PAF-
AH inhibitor -
GC44943
sPLA2 Inhibitor
An orally active inhibitor of sPLA2-IIA
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GC44794
Pyrrophenone
Inhibitor of cPLA2
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GC44664
p-Nitrophenylphosphorylcholine
A chromogenic PLC substrate
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GC44549
Palmitoyl thio-PC
A chromogenic substrate for PLA2
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GC44223
ML-299
Dual inhibitor of PLD1 and PLD2
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GC44222
ML-298
A selective inhibitor of PLD2
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GC43812
HEPC
A thioester phospholipase substrate
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GC43756
GK187
A GVIA iPLA2 inhibitor
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GC43695
Folipastatin
An inhibitor of PLA2
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GC43671
FKGK 18
An inhibitor of GVIA iPLA2
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GC43670
FKGK 11
A selective iPLA2 inhibitor
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GC43305
Compound 48/80 (hydrochloride)
复合物48/80(盐酸)(C48/80三盐酸盐)是N-甲基-p-甲氧苯乙胺与甲醛的缩聚产物混合物。
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GC43179
CAY10590
A potent and selective sPLA2 inhibitor
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GC43161
CAY10502
A potent inhibitor of cPLA2α
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GC42885
AX 048
A cPLA2 inhibitor
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GC42855
ARN19874
An inhibitor of NAPE-PLD
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GC42843
Arachidonoyl thio-PC
A PLA2 substrate
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GC42611
7-hydroxycoumarinyl-γ-Linolenate
A fluorogenic substrate