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Phospholipase(磷脂酶)

Phospholipases are enzymes that catalyze the hydrolysis of phospholipids into fatty acids and other lipid mediators. It plays a variety of roles in tumorgenesis , inflammation and brain disorders etc.

  1. Cat.No. 产品名称 Information
  2. GC69862 SB-435495 SB-435495 是一种有效的、选择性的、可逆的、非共价的、具有口服活性的 Lp-PLA2 抑制剂,IC50 为 0.06 nM。
  3. GC69371 LFHP-1c LFHP-1c 是一种 PGAM5 抑制剂,在缺血性脑卒中中具有神经保护活性。LFHP-1c 保护血脑屏障完整性免受缺血损伤。LFHP-1c 与内皮细胞 PGAM5 结合,抑制 PGAM5 磷酸酶活性,抑制 PGAM5 与 NRF2 的相互作用。LFHP-1c 具有体外和体内保护作用。
  4. GC69136 Fuzapladib sodium Fuzapladib sodium (IS-741 sodium) 是一种有效的具有口服活性的磷脂酶 A2 (phospholipase A2) 抑制剂。Fuzapladib sodium 可以阻断炎症细胞与微血管内皮细胞的粘附,抑制嗜中性粒细胞浸润到胰腺或急性胰腺炎中,具有抗急性胰腺炎作用。
  5. GC67909 GSK2647544 GSK2647544 是一种口服的、选择性的 Lp-PLA2 抑制剂。Lp-PLA2是一种钙非依赖性磷脂酶 A2,具有促炎活性,主要由单核细胞衍生的巨噬细胞分泌。
  6. GC52315 GK241 An sPLA2 (Type IIA) inhibitor
  7. GC67211 BAPTA tetrapotassium An extracellular calcium chelator
  8. GC65595 3-Nitrocoumarin 3-Nitrocoumarin (3-NC) 是一个有效的、磷脂酶 C-γ (PLC-γ) 的选择性抑制剂。
  9. GC64388 CCT129957 CCT129957 是一种吲哚衍生物,也是一种有效的磷脂酶 C-γ (PLC-γ) 抑制剂,IC50 为 ~3 μM,GC50 为 15 μM。CCT129957 以约 15 μM 的浓度抑制鳞状细胞中 Ca2+ 的释放。
  10. GC52080 LEI-110 An AdPLA2 inhibitor
  11. GC49784 AZD 2716 An sPLA2 inhibitor
  12. GC64306 ROC-0929 ROC-0929 (compound 13a) 是一种有效且选择性的分泌型磷脂酶 A2 (sPLA2s) 抑制剂。其IC50值为 80 nM,特异性靶点为hGX。ROC-0929 抑制 ERK1/2 和 p-38 的磷酸化。分泌型磷脂酶 A2 (sPLA2s) 是富含二硫键的 Ca2+ 依赖性酶家族,可水解甘油磷脂的 sn-2 位以释放脂肪酸和溶血磷脂。ROC-0929具有研究炎症相关疾病的潜力。
  13. GC64070 Omeprazole-d3-1 An internal standard for the quantification of omeprazole
  14. GC63860 Rapanone Rapanone 是一种天然苯醌。Rapanone 具有广泛的生物作用,包括抗肿瘤、抗氧化、抗炎、抗菌和抗寄生虫。Rapanone 还是一种有效和选择性的人滑膜 PLA2 抑制剂,IC50 值为 2.6 μM。
  15. GC49635 LY433771 An inhibitor of type X sPLA2
  16. GC49546 Melittin (trifluoroacetate salt) The principal cytotoxic component of bee venom
  17. GC49457 Oleoyl-Coenzyme A (sodium salt) 酰基辅酶A硫酯
  18. GC61689 Alminoprofen Alminoprofen是苯丙酸类非甾体抗炎药(NSAID)。Alminoprofen同时具有抑制分泌磷脂酶A2(sPLA2)活性和抗环氧化酶(COX-2)的活性。
  19. GC50738 SGC 3027N
  20. GC50726 ASB 14780 ASB 14780 是一种 4-苯氧基衍生物,是胞质磷脂酶 A2α (cPLA2α) 抑制剂,IC50 值为 20 nM。
  21. GC47049 CAY10641 An inactive alcohol derivative of a highly potent cPLA2 inhibitor
  22. GC46761 9-Oxononanoic Acid An oxidized fatty acid
  23. GC46352 (S)-DO271 An inactive control for DO264
  24. GC61355 Tris(2,4-di-tert-butylphenyl)phosphate Tris(2,4-di-tert-butylphenyl)phosphate是从VitexnegundoL.中分离的一种活性化合物,具有抗炎活性,并通过分子对接抑制了分泌性磷脂酶A2(sPLA2)。
  25. GC61344 trans-Benzylideneacetone Trans-4-Phenyl-3-buten-2-one (trans-Benzylideneacetone, trans-Benzalacetone, trans-Benzylideneacetone) is an inhibitor of the enzyme phospholipase A2 (PLA2). Trans-4-Phenyl-3-buten-2-one is used as a flavouring agent, a fragrance and a bacterial metabolite.
  26. GC61155 Omeprazole sodium An irreversible inhibitor of the gastric proton pump
  27. GC61040 Melittin TFA Melittin (MLT, Forapin, Forapine) is an activator of phospholipase A2 (PLA2) that stimulates the activity of the low molecular weight PLA2, while it does not the increase the activity of the high molecular weight enzyme.
  28. GC60982 LEI-401 An NAPE-PLD inhibitor
  29. GC45995 DO264 An ABHD12 inhibitor
  30. GC45618 (±)-trans-GK563 A GVIA iPLA2 inhibitor
  31. GC37674 SPK-601 SPK-601(LMV-601)是卵磷脂特异磷脂酶C(PC-PLC)抑制剂,可用作抗菌剂。
  32. GC35390 Aristolochic acid C An alkaloid with anticancer activity
  33. GC35065 1-Linoleoyl Glycerol A PAF-AH inhibitor
  34. GC44943 sPLA2 Inhibitor An orally active inhibitor of sPLA2-IIA
  35. GC44794 Pyrrophenone

    Inhibitor of cPLA2

  36. GC44664 p-Nitrophenylphosphorylcholine A chromogenic PLC substrate
  37. GC44549 Palmitoyl thio-PC A chromogenic substrate for PLA2
  38. GC44223 ML-299 Dual inhibitor of PLD1 and PLD2
  39. GC44222 ML-298 A selective inhibitor of PLD2
  40. GC43812 HEPC A thioester phospholipase substrate
  41. GC43756 GK187 A GVIA iPLA2 inhibitor
  42. GC43695 Folipastatin An inhibitor of PLA2
  43. GC43671 FKGK 18 An inhibitor of GVIA iPLA2
  44. GC43670 FKGK 11 A selective iPLA2 inhibitor
  45. GC43305 Compound 48/80 (hydrochloride)

    Compound 48/80 (hydrochloride)是一种组胺 (histamine) 释放剂和肥大细胞 (mast cell) 脱颗粒剂,也是MrgprB2/X2(Mas-related G protein-coupled receptor B2/X2)的激动剂。Compound 48/80 (hydrochloride)能够抑制人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性。

  46. GC43179 CAY10590 A potent and selective sPLA2 inhibitor
  47. GC43161 CAY10502 A potent inhibitor of cPLA2α
  48. GC42885 AX 048 A cPLA2 inhibitor
  49. GC42855 ARN19874 An inhibitor of NAPE-PLD
  50. GC42843 Arachidonoyl thio-PC A PLA2 substrate
  51. GC42611 7-hydroxycoumarinyl-γ-Linolenate A fluorogenic substrate

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