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Oleoyl-Coenzyme A (sodium salt)

(Synonyms: Oleoyl (cis-9-C18:1)-CoA, Oleoyl-CoA) 目录号 : GC49457

酰基辅酶A硫酯

Oleoyl-Coenzyme A (sodium salt) Chemical Structure

规格 价格 库存 购买数量
1 mg
¥397.00
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5 mg
¥1,792.00
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10 mg
¥2,982.00
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25 mg
¥5,948.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Oleoyl-coenzyme A (oleoyl-CoA) is a thioester of oleic acid and CoA . It is a substrate for several acyl-CoA-dependent enzymes, including acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1), ACAT-2, acyl-CoA dehydrogenase-9 (ACAD-9), membrane-bound O-acyltransferase 1 (MBOAT1), and MBOAT2.1,2,3 Oleoyl-CoA binds the fatty acid metabolism regulator protein (FadR) promoter in E. coli (Ki = 0.005 µM).4 Oleoyl-CoA (1 µM) activates sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 in Xenopus oocytes.5

1.Seo, T., Oelkers, P.M., Giattina, M.R., et al.Differential modulation of ACAT1 and ACAT2 transcription and activity by long chain free fatty acids in cultured cellsBiochemistry40(15)4756-4762(2001) 2.Ensenauer, R., He, M., Willard, J.-M., et al.Human acyl-CoA dehydrogenase-9 plays a novel role in the mitochondrial β-oxidation of unsaturated fatty acidsJ. Biol. Chem.280(37)32309-32316(2005) 3.GijÓn, M.A., Riekhof, W.R., Zarini, S., et al.Lysophospholipid acyltransferases and arachidonate recycling in human neutrophilsJ. Biol. Chem.283(44)30235-30245(2008) 4.DiRusso, C.C., Heimert, T.L., and Metzger, A.K.Characterization of FadR, a global transcriptional regulator of fatty acid metabolism in Escherichia coli. Interaction with the fadB promoter is prevented by long chain fatty acyl coenzyme AJ. Biol. Chem.267(12)8685-8691(1992) 5.Gribble, F.M., Proks, P., Corkey, B.E., et al.Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoAJ. Biol. Chem.273(41)26383-26387(1998)

Chemical Properties

Cas No. N/A SDF Download SDF
别名 Oleoyl (cis-9-C18:1)-CoA, Oleoyl-CoA
Canonical SMILES O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCCCCCC/C=C\CCCCCCCC)=O)=O)=O)(O)=O)(O)=O)[C@H]1OP(O)(O)=O.[Na]
分子式 C39H68N7O17P3S • Na 分子量 1055
溶解度 Water: 10mg/mL 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 0.9479 mL 4.7393 mL 9.4787 mL
5 mM 0.1896 mL 0.9479 mL 1.8957 mL
10 mM 0.0948 mL 0.4739 mL 0.9479 mL
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