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Home >> Signaling Pathways >> Metabolism >> phosphatases

phosphatases(磷酸酶)

Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.

Products for  phosphatases

  1. Cat.No. 产品名称 Information
  2. GC91775 h-e5'NT Inhibitor 5C

    Human Ecto-5'-nucleotidase Inhibitor 5C

     h-e5'NT Inhibitor 5C is an inhibitor of ecto-5'-nucleotidase, also known as CD73 (IC50s = 0.37 and 1.66 µM for the human and rat enzymes, respectively).
  3. GC91767 ENPP3 Inhibitor 5J ENPP3 inhibitor 5J is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) and ENPP3 (IC50s = 0.59 and 0.62 µM, respectively, for the human enzymes).
  4. GC91761 ABBV-CLS-484 (hydrochloride)

    Osunprotafib

     ABBV-CLS-484 is a dual inhibitor of protein tyrosine phosphatase 1N (PTP1N) and PTP2N (IC50s = 2.5 and 1.8 nM, respectively).
  5. GC91547 Tanzawaic Acid B

    (+)-Tanzawaic Acid B

     Tanzawaic acid B is a fungal metabolite that has been found in Penicillium and has diverse biological activities.
  6. GC19921 Phenylarsine Oxide

    氧化苯胂,Arsenoso-Benzen;FenylArsinoxid;Oxophenyl-Arsin;Oxophenylarsine;Pao;Phenyl Arsene Oxide;Phenyl ARSENOxide;PhenylARSINE Oxide

     An organoarsenic compound
  7. GC49494 4-Aminobenzylphosphonic Acid

    4-氨基苄基膦酸

     An alkaline phosphatase inhibitor
  8. GC49403 Benzarone

    苯扎隆,Fragivix

     An active metabolite of benzbromarone
  9. GC49401 Triptolide-d3

    PG490-d3

     Triptolide-d3 (PG490-d3) 是氘标记的雷公藤内酯。雷公藤内酯是从雷公藤根中提取的二萜类三环氧化物，具有免疫抑制、抗炎、抗增殖和抗肿瘤作用。雷公藤内酯是一种 NF-κB 活化抑制剂。
  10. GC49169 3,8’-Biapigenin

    I3,II8-Biapigenin, 3,8\-Biapigenin

     A biflavonoid with diverse biological activities
  11. GC49074 Forphenicine A bacterial metabolite and an inhibitor of alkaline phosphatase
  12. GC62215 CRT0273750 CRT0273750 是 ATX 抑制剂的先导化合物，并调节血浆中 LPA 水平。CRT0273750 可用于 ATX/LPA 依赖性癌症模型。
  13. GC19775 M2N12 M2N12 是一种有效且高度选择性的细胞分裂周期 25C 蛋白磷酸酶 (Cdc25C) 抑制剂，IC50 值为 0.09 μM。 M2N12 对 Cdc25A 和 Cdc25B 也有很好的活性，IC50 值分别为 0.53 μM 和 1.39 μM。 M2N12具有抗肿瘤活性，可用于癌症研究。
  14. GC48509 Apigenin 7-O-Glucuronide (hydrate) Apigenin 7-O-glucuronide is a flavonoid that has been found in J
  15. GC47674 Mifepristone-d3

    RU486-d3; RU 38486-d3

     A neuropeptide with diverse biological activities
  16. GC46897 AUTEN-99

    Autophagy enhancer-99 hydrobromide

     An inhibitor of MRMR14/Jumpy
  17. GC39514 TNO155

    (3S,4S)-8-(6-氨基-5-((2-氨基-3-氯吡啶基-4-基)硫代)吡嗪-2-基)-3-甲基-2-氧杂-8-氮杂螺[4.5]癸-4-胺,TNO155

     A SHP-2 inhibitor
  18. GC50568 PHPS1 sodium salt A selective SHP-2 inhibitor
  19. GC50357 CX08005 Competitive PTP1B inhibitor
  20. GC50041 VO-OHpic A specific inhibitor of PTEN
  21. GC39160 BCI-215 BCI-215 是一种高效、肿瘤细胞选择性的双重特异性磷酸酶 DUSP-MKP 抑制剂。BCI-215 对肿瘤细胞有细胞毒性，但对正常细胞无毒性。
  22. GC38919 KY-226

    抑制剂

    KY-226 is a potent, selective, orally active and allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 μM for human PTP1B activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively.
  23. GC38916 GNF362 GNF362 是肌醇三磷酸3'激酶 B (Itpkb) 的选择性，有效且可口服生物利用的抑制剂，IC50为 9 nM。 GNF362 还抑制 Itpka 和 Itpkc，IC50 值分别为 20 nM 和 19 nM。 肌醇三磷酸3'激酶 B (Itpkb) 是一种 Ca2+ 依赖性激酶，其磷酸化 Ins (1,4,5) P3 的 3' 位置，生成肌醇 1,3,4,5-四磷酸 [Ins (1,3,4,5) P4]。
  24. GC46011 SPI 112 A cell-impermeable SHP-2 inhibitor
  25. GC38846 SBI-425 A TNAP inhibitor
  26. GC38783 Ginkgolic acid C17:1

    银杏酸 C17

     A phenolic acid with antibacterial and anticancer activities
  27. GC38646 BCI

    (E)-BCI

     BCI 作为一种选择性双特异性磷酸酶 6 (DUSP6) 抑制剂，可以抑制肿瘤生长和巨噬细胞炎症。
  28. GC38539 Raphin1 acetate Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase with Kd of 0.033 μM.
  29. GC38486 Momordicoside A

    苦瓜苷A

     Momordicoside A 是从苦瓜中分离得到的。Momordicoside A 对蛋白酪氨酸磷酸酶 (PTP1B) 具有抑制作用。
  30. GC38467 BTdCPU BTdCPU is a potent activator of heme regulated inhibitor kinase (HRI), one of eukaryotic translation initiation factor 2α kinases (eIF2α-kinases).
  31. GC38445 DPM-1001 DPM-1001 是一种有效的，特异性的，口服生物可利用且非竞争性的蛋白酪氨酸磷酸酶 (PTP1B) 抑制剂，其 IC50 为 100 nM，特异性 PTP1B 抑制剂 MSI-1436 的类似物 (IC50=600 nM)。DPM-1001 具有抗糖尿病特性。
  32. GC38189 Raphin1 Raphin1 is an orally bioavailable, selective inhibitor of R15B (PPP1R15B, a regulatory subunit of protein phosphatase 1). Raphin1 binds strongly to the R15B-PP1c holophosphatase with Kd of 33 nM.
  33. GC37741 Tartaric acid disodium dihydrate

    酒石酸钠,Sodium tartrate dibasic dihydrate; Sodium tartrate dihydrate

     酒石酸钠二元二水合物是一种钠盐, 在分子生物学和细胞培养中用作缓冲液, 是酸性磷酸酶抑制剂, 增加秋水仙碱结合tubulin1率。
  34. GC37037 PTP1B-IN-1

    5-苯基-1,2,5-噻二唑烷-3-酮1,1-二氧化物,PTP1B inhibitor

     PTP1B-IN-1是PTP1B小分子抑制剂，IC50值为1.6mM,常作为类似物衍生的母核。
  35. GC36607 Microcystin-LR

    微囊藻毒素(LR亚型),Cyanoginosin-LR; MC-LR; Toxin T 17 (Microcystis aeruginosa)

    A potent protein phosphatase inhibitor
  36. GC36448 Licoflavone A

    甘草黄酮 A

     Licoflavone A 是从甘草根中得到的黄酮类化合物，抑制酪氨酸磷酸酶 1B (PTP1B) 的活性，IC50 值为 54.5 μM。
  37. GC35791 cyt-PTPε Inhibitor-1 cyt-PTPε Inhibitor-1 是一种有效的胞质蛋白酪氨酸磷酸酶 cyt-PTPε 抑制剂，与 cyt-PTPε 的催化结构域结合，抑制 c-Src 的活化 (c-Src 去磷酸化)，具有抗破骨细胞的活性。
  38. GC35627 CDC25B-IN-1 CDC25B-IN-1 (compound 4a) 是一种有效的细胞分裂周期 25B (CDC25B) 磷酸酶抑制剂，其 Ki 值为 8.5 μM。CDC25B-IN-1 能有效抑制细胞增殖和克隆形成，导致 G2/M 期停滞。
  39. GC35298 Aloe-emodin-8-O-β-D-glucopyranoside

    芦荟大黄素-8-O-β-D-葡萄糖苷

     Aloe-emodin-8-O-β-D-glucopyranoside 是从 Saussrurea lappa 中分离出的化合物，是温和的人类蛋白酪氨酸磷酸酶 1B (hPTP1B) 抑制剂，其 IC50 值为 26.6 μM。
  40. GC35024 [pTyr5] EGFR 988-993 [pTyr5] EGFR (988-993) 来源于表皮生长因子受体(EGFR 988-993)的自磷酸化位点(Tyr992)。[pTyr5] EGFR(988-993)常与催化活性低的蛋白-酪氨酸磷酸1B (PTP1B)结合。
  41. GC45149 VK3-OCH3

    Vitamin K3-OCH3

     An analog of vitamin K3
  42. GC44887 SHP099

    SHP-099游离

     An orally bioavailable inhibitor of SHP2
  43. GC44775 PTP1B Inhibitor

    3-(3,5-二溴-4-羟基苯甲酰基)-2-乙基-N-[4-[(2-噻唑氨基)磺酰基]苯基]-6-苯并呋喃磺酰胺

     A cell-permeable allosteric inhibitor of PTP1B
  44. GC44774 PTP Inhibitor III

    α-Bromo-4-(carboxymethoxy)acetophenone, Protein Tyrosine Phosphatase Inhibitor III

     A general PTP inhibitor
  45. GC44637 PHPS1

    PTP Inhibitor V

     A selective SHP-2 inhibitor
  46. GC44226 MLS-0322825 Cmpd 23 MLS-0322825 Cmpd 23 是一种低分子量蛋白酪氨酸磷酸酶 (LMPTP) 的选择性抑制剂，IC50 为 0.8 μM LMPTP-A。
  47. GC41443 TAN 1364B

    RK-682 (rac-1)

     A PTP inhibitor
  48. GC41305 DA-3003-2

    NSC 663285

     A Cdc25 phosphatase inhibitor
  49. GC34562 DT-061 DT-061 (SMAP) is a bioavailable PP2A activator. It decreases cell viability in HCC827 and HCC3255 cell lines, with IC50 values of 14.3 μM and 12.4 μM respectively.
  50. GC34353 LMPTP INHIBITOR 1 hydrochloride LMPTPINHIBITOR1(hydrochloride)是一种选择性的低分子量蛋白酪氨酸磷酸酶(LMPTP)抑制剂，能够抑制LMPTP-A的活性，IC50值为0.8μM。
  51. GC34178 Isocryptotanshinone

    异隐丹参酮

    Isocryptotanshinone是一种有效的信号传导与转录激活因子3(STAT3)和蛋白酪氨酸磷酸酶1B(PTP1B)的抑制剂，其对PTP1B的IC50值为56.1μM。

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