phosphatases(磷酸酶)
Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.
- Cat.No. 产品名称 Information
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GC49494
4-Aminobenzylphosphonic Acid
An alkaline phosphatase inhibitor
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GC49403
Benzarone
An active metabolite of benzbromarone
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GC49401
Triptolide-d3
Triptolide-d3 (PG490-d3) 是氘标记的雷公藤内酯。雷公藤内酯是从雷公藤根中提取的二萜类三环氧化物,具有免疫抑制、抗炎、抗增殖和抗肿瘤作用。雷公藤内酯是一种 NF-κB 活化抑制剂。
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GC49169
3,8’-Biapigenin
A biflavonoid with diverse biological activities
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GC49074
Forphenicine
A bacterial metabolite and an inhibitor of alkaline phosphatase
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GC46897
AUTEN-99
An inhibitor of MRMR14/Jumpy
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GC39514
TNO155
A SHP-2 inhibitor
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GC50568
PHPS1 sodium salt
A selective SHP-2 inhibitor
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GC50357
CX08005
Competitive PTP1B inhibitor
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GC50041
VO-OHpic
A specific inhibitor of PTEN
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GC39160
BCI-215
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GC38919
KY-226
KY-226 is a potent, selective, orally active and allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 μM for human PTP1B activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively.
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GC38916
GNF362
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GC46011
SPI 112
A cell-impermeable SHP-2 inhibitor
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GC38846
SBI-425
A TNAP inhibitor
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GC38783
Ginkgolic acid C17:1
A phenolic acid with antibacterial and anticancer activities
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GC38646
BCI
BCI ((E)-BCI) 是一种 DUSP6(双特异性磷酸酶 6)抑制剂。
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GC38539
Raphin1 acetate
Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase with Kd of 0.033 μM.
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GC38486
Momordicoside A
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GC38467
BTdCPU
BTdCPU is a potent activator of heme regulated inhibitor kinase (HRI), one of eukaryotic translation initiation factor 2α kinases (eIF2α-kinases).
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GC38445
DPM-1001
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GC38189
Raphin1
Raphin1 is an orally bioavailable, selective inhibitor of R15B (PPP1R15B, a regulatory subunit of protein phosphatase 1). Raphin1 binds strongly to the R15B-PP1c holophosphatase with Kd of 33 nM.
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GC37741
Tartaric acid disodium dihydrate
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GC37037
PTP1B-IN-1
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GC36607
Microcystin-LR
A potent protein phosphatase inhibitor
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GC36448
Licoflavone A
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GC35791
cyt-PTPε Inhibitor-1
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GC35627
CDC25B-IN-1
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GC35298
Aloe-emodin-8-O-β-D-glucopyranoside
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GC35024
[pTyr5] EGFR 988-993
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GC45149
VK3-OCH3
An analog of vitamin K3
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GC44887
SHP099
An orally bioavailable inhibitor of SHP2
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GC44775
PTP1B Inhibitor
A cell-permeable allosteric inhibitor of PTP1B
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GC44774
PTP Inhibitor III
A general PTP inhibitor
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GC44637
PHPS1
A selective SHP-2 inhibitor
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GC44226
MLS-0322825 Cmpd 23
MLS-0322825 Cmpd 23 是一种低分子量蛋白酪氨酸磷酸酶 (LMPTP) 的选择性抑制剂,IC50 为 0.8 μM LMPTP-A。
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GC41443
TAN 1364B
A PTP inhibitor
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GC41305
DA-3003-2
A Cdc25 phosphatase inhibitor
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GC34562
DT-061
DT-061 (SMAP) is a bioavailable PP2A activator. It decreases cell viability in HCC827 and HCC3255 cell lines, with IC50 values of 14.3 μM and 12.4 μM respectively.
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GC34353
LMPTP INHIBITOR 1 hydrochloride
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GC34178
Isocryptotanshinone
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GC33816
Ertiprotafib (PTP 112)
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GC33791
Isotanshinone IIA
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GC33345
BN82002
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GC33227
F1063-0967
A DUSP26 inhibitor
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GC33059
3α-Aminocholestane
An inhibitor of SHP-1
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GC33044
RMC-4550
A SHP-2 inhibitor
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GC32852
LTV-1
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GC32783
Rosiptor (AQX-1125)
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GC32709
Stibogluconate sodium (Sodium stibogluconate)
An anti-Leishmania antimony derivative