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Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.

  1. Cat.No. 产品名称 Information
  2. GC49494 4-Aminobenzylphosphonic Acid An alkaline phosphatase inhibitor
  3. GC49403 Benzarone An active metabolite of benzbromarone
  4. GC49401 Triptolide-d3 Triptolide-d3 (PG490-d3) 是氘标记的雷公藤内酯。雷公藤内酯是从雷公藤根中提取的二萜类三环氧化物,具有免疫抑制、抗炎、抗增殖和抗肿瘤作用。雷公藤内酯是一种 NF-κB 活化抑制剂。
  5. GC49169 3,8’-Biapigenin A biflavonoid with diverse biological activities
  6. GC49074 Forphenicine A bacterial metabolite and an inhibitor of alkaline phosphatase
  7. GC46897 AUTEN-99 An inhibitor of MRMR14/Jumpy
  8. GC39514 TNO155 A SHP-2 inhibitor
  9. GC50568 PHPS1 sodium salt A selective SHP-2 inhibitor
  10. GC50357 CX08005 Competitive PTP1B inhibitor
  11. GC50041 VO-OHpic A specific inhibitor of PTEN
  12. GC39160 BCI-215
  13. GC38919 KY-226 KY-226 is a potent, selective, orally active and allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 μM for human PTP1B activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively.
  14. GC38916 GNF362
  15. GC46011 SPI 112 A cell-impermeable SHP-2 inhibitor
  16. GC38846 SBI-425 A TNAP inhibitor
  17. GC38783 Ginkgolic acid C17:1 A phenolic acid with antibacterial and anticancer activities
  18. GC38646 BCI BCI ((E)-BCI) 是一种 DUSP6(双特异性磷酸酶 6)抑制剂。
  19. GC38539 Raphin1 acetate Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase with Kd of 0.033 μM.
  20. GC38486 Momordicoside A
  21. GC38467 BTdCPU BTdCPU is a potent activator of heme regulated inhibitor kinase (HRI), one of eukaryotic translation initiation factor 2α kinases (eIF2α-kinases).
  22. GC38445 DPM-1001
  23. GC38189 Raphin1 Raphin1 is an orally bioavailable, selective inhibitor of R15B (PPP1R15B, a regulatory subunit of protein phosphatase 1). Raphin1 binds strongly to the R15B-PP1c holophosphatase with Kd of 33 nM.
  24. GC37741 Tartaric acid disodium dihydrate
  25. GC37037 PTP1B-IN-1
  26. GC36607 Microcystin-LR A potent protein phosphatase inhibitor
  27. GC36448 Licoflavone A
  28. GC35791 cyt-PTPε Inhibitor-1
  29. GC35627 CDC25B-IN-1
  30. GC35298 Aloe-emodin-8-O-β-D-glucopyranoside
  31. GC35024 [pTyr5] EGFR 988-993
  32. GC45149 VK3-OCH3 An analog of vitamin K3
  33. GC44887 SHP099 An orally bioavailable inhibitor of SHP2
  34. GC44775 PTP1B Inhibitor A cell-permeable allosteric inhibitor of PTP1B
  35. GC44774 PTP Inhibitor III A general PTP inhibitor
  36. GC44637 PHPS1 A selective SHP-2 inhibitor
  37. GC44226 MLS-0322825 Cmpd 23 MLS-0322825 Cmpd 23 是一种低分子量蛋白酪氨酸磷酸酶 (LMPTP) 的选择性抑制剂,IC50 为 0.8 μM LMPTP-A。
  38. GC41443 TAN 1364B A PTP inhibitor
  39. GC41305 DA-3003-2 A Cdc25 phosphatase inhibitor
  40. GC34562 DT-061 DT-061 (SMAP) is a bioavailable PP2A activator. It decreases cell viability in HCC827 and HCC3255 cell lines, with IC50 values of 14.3 μM and 12.4 μM respectively.
  41. GC34353 LMPTP INHIBITOR 1 hydrochloride
  42. GC34178 Isocryptotanshinone
  43. GC33816 Ertiprotafib (PTP 112)
  44. GC33791 Isotanshinone IIA
  45. GC33345 BN82002
  46. GC33227 F1063-0967 A DUSP26 inhibitor
  47. GC33059 3α-Aminocholestane An inhibitor of SHP-1
  48. GC33044 RMC-4550 A SHP-2 inhibitor
  49. GC32852 LTV-1
  50. GC32783 Rosiptor (AQX-1125)
  51. GC32709 Stibogluconate sodium (Sodium stibogluconate) An anti-Leishmania antimony derivative

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