phosphatases(磷酸酶)
Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.
Products for phosphatases
- Cat.No. 产品名称 Information
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GC49494
4-Aminobenzylphosphonic Acid
4-氨基苄基膦酸
An alkaline phosphatase inhibitor -
GC49403
Benzarone
苯扎隆,Fragivix
An active metabolite of benzbromarone -
GC49401
Triptolide-d3
PG490-d3
Triptolide-d3 (PG490-d3) 是氘标记的雷公藤内酯。雷公藤内酯是从雷公藤根中提取的二萜类三环氧化物,具有免疫抑制、抗炎、抗增殖和抗肿瘤作用。雷公藤内酯是一种 NF-κB 活化抑制剂。 -
GC49169
3,8’-Biapigenin
I3,II8-Biapigenin, 3,8\-Biapigenin
A biflavonoid with diverse biological activities -
GC49074
Forphenicine
A bacterial metabolite and an inhibitor of alkaline phosphatase
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GC46897
AUTEN-99
Autophagy enhancer-99 hydrobromide
An inhibitor of MRMR14/Jumpy -
GC39514
TNO155
(3S,4S)-8-(6-氨基-5-((2-氨基-3-氯吡啶基-4-基)硫代)吡嗪-2-基)-3-甲基-2-氧杂-8-氮杂螺[4.5]癸-4-胺,TNO155
A SHP-2 inhibitor -
GC50568
PHPS1 sodium salt
A selective SHP-2 inhibitor
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GC50357
CX08005
Competitive PTP1B inhibitor
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GC50041
VO-OHpic
A specific inhibitor of PTEN
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GC39160
BCI-215
BCI-215 是一种高效、肿瘤细胞选择性的双重特异性磷酸酶 DUSP-MKP 抑制剂。BCI-215 对肿瘤细胞有细胞毒性,但对正常细胞无毒性。
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GC38919
KY-226
抑制剂
KY-226 is a potent, selective, orally active and allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 μM for human PTP1B activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively.
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GC38916
GNF362
GNF362 是肌醇三磷酸3'激酶 B (Itpkb) 的选择性,有效且可口服生物利用的抑制剂,IC50为 9 nM。 GNF362 还抑制 Itpka 和 Itpkc,IC50 值分别为 20 nM 和 19 nM。 肌醇三磷酸3'激酶 B (Itpkb) 是一种 Ca2+ 依赖性激酶,其磷酸化 Ins (1,4,5) P3 的 3' 位置,生成肌醇 1,3,4,5-四磷酸 [Ins (1,3,4,5) P4]。
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GC46011
SPI 112
A cell-impermeable SHP-2 inhibitor
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GC38846
SBI-425
A TNAP inhibitor
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GC38783
Ginkgolic acid C17:1
银杏酸 C17
A phenolic acid with antibacterial and anticancer activities -
GC38646
BCI
(E)-BCI
BCI ((E)-BCI) 是一种 DUSP6(双特异性磷酸酶 6)抑制剂。 -
GC38539
Raphin1 acetate
Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase with Kd of 0.033 μM.
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GC38486
Momordicoside A
苦瓜苷A
Momordicoside A 是从苦瓜中分离得到的。Momordicoside A 对蛋白酪氨酸磷酸酶 (PTP1B) 具有抑制作用。 -
GC38467
BTdCPU
BTdCPU is a potent activator of heme regulated inhibitor kinase (HRI), one of eukaryotic translation initiation factor 2α kinases (eIF2α-kinases).
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GC38445
DPM-1001
DPM-1001 是一种有效的,特异性的,口服生物可利用且非竞争性的蛋白酪氨酸磷酸酶 (PTP1B) 抑制剂,其 IC50 为 100 nM,特异性 PTP1B 抑制剂 MSI-1436 的类似物 (IC50=600 nM)。DPM-1001 具有抗糖尿病特性。
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GC38189
Raphin1
Raphin1 is an orally bioavailable, selective inhibitor of R15B (PPP1R15B, a regulatory subunit of protein phosphatase 1). Raphin1 binds strongly to the R15B-PP1c holophosphatase with Kd of 33 nM.
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GC37741
Tartaric acid disodium dihydrate
酒石酸钠,Sodium tartrate dibasic dihydrate; Sodium tartrate dihydrate
酒石酸钠二元二水合物是一种钠盐, 在分子生物学和细胞培养中用作缓冲液, 是酸性磷酸酶抑制剂, 增加秋水仙碱结合tubulin1率。 -
GC37037
PTP1B-IN-1
5-苯基-1,2,5-噻二唑烷-3-酮1,1-二氧化物,PTP1B inhibitor
PTP1B-IN-1是PTP1B小分子抑制剂,IC50值为1.6mM,常作为类似物衍生的母核。 -
GC36607
Microcystin-LR
微囊藻毒素(LR亚型),Cyanoginosin-LR; MC-LR; Toxin T 17 (Microcystis aeruginosa)
A potent protein phosphatase inhibitor
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GC36448
Licoflavone A
甘草黄酮 A
Licoflavone A 是从甘草根中得到的黄酮类化合物,抑制酪氨酸磷酸酶 1B (PTP1B) 的活性,IC50 值为 54.5 μM。 -
GC35791
cyt-PTPε Inhibitor-1
cyt-PTPε Inhibitor-1 是一种有效的胞质蛋白酪氨酸磷酸酶 cyt-PTPε 抑制剂,与 cyt-PTPε 的催化结构域结合,抑制 c-Src 的活化 (c-Src 去磷酸化),具有抗破骨细胞的活性。
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GC35627
CDC25B-IN-1
CDC25B-IN-1 (compound 4a) 是一种有效的细胞分裂周期 25B (CDC25B) 磷酸酶抑制剂,其 Ki 值为 8.5 μM。CDC25B-IN-1 能有效抑制细胞增殖和克隆形成,导致 G2/M 期停滞。
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GC35298
Aloe-emodin-8-O-β-D-glucopyranoside
芦荟大黄素-8-O-β-D-葡萄糖苷
Aloe-emodin-8-O-β-D-glucopyranoside 是从 Saussrurea lappa 中分离出的化合物,是温和的人类蛋白酪氨酸磷酸酶 1B (hPTP1B) 抑制剂,其 IC50 值为 26.6 μM。 -
GC35024
[pTyr5] EGFR 988-993
[pTyr5] EGFR (988-993) 来源于表皮生长因子受体(EGFR 988-993)的自磷酸化位点(Tyr992)。[pTyr5] EGFR(988-993)常与催化活性低的蛋白-酪氨酸磷酸1B (PTP1B)结合。
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GC45149
VK3-OCH3
Vitamin K3-OCH3
An analog of vitamin K3 -
GC44887
SHP099
SHP-099游离
An orally bioavailable inhibitor of SHP2 -
GC44775
PTP1B Inhibitor
3-(3,5-二溴-4-羟基苯甲酰基)-2-乙基-N-[4-[(2-噻唑氨基)磺酰基]苯基]-6-苯并呋喃磺酰胺
A cell-permeable allosteric inhibitor of PTP1B -
GC44774
PTP Inhibitor III
α-Bromo-4-(carboxymethoxy)acetophenone, Protein Tyrosine Phosphatase Inhibitor III
A general PTP inhibitor -
GC44637
PHPS1
PTP Inhibitor V
A selective SHP-2 inhibitor -
GC44226
MLS-0322825 Cmpd 23
MLS-0322825 Cmpd 23 是一种低分子量蛋白酪氨酸磷酸酶 (LMPTP) 的选择性抑制剂,IC50 为 0.8 μM LMPTP-A。
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GC41443
TAN 1364B
RK-682 (rac-1)
A PTP inhibitor -
GC41305
DA-3003-2
NSC 663285
A Cdc25 phosphatase inhibitor -
GC34562
DT-061
DT-061 (SMAP) is a bioavailable PP2A activator. It decreases cell viability in HCC827 and HCC3255 cell lines, with IC50 values of 14.3 μM and 12.4 μM respectively.
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GC34353
LMPTP INHIBITOR 1 hydrochloride
LMPTPINHIBITOR1(hydrochloride)是一种选择性的低分子量蛋白酪氨酸磷酸酶(LMPTP)抑制剂,能够抑制LMPTP-A的活性,IC50值为0.8μM。
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GC34178
Isocryptotanshinone
异隐丹参酮
Isocryptotanshinone是一种有效的信号传导与转录激活因子3(STAT3)和蛋白酪氨酸磷酸酶1B(PTP1B)的抑制剂,其对PTP1B的IC50值为56.1μM。
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GC33816
Ertiprotafib (PTP 112)
PTP 112
Ertiprotafib (PTP 112) 是 PTP1B,IkB 激酶 β 的抑制剂; (IKK-β) 和双 PPARα;和 PPARβ;激动剂,IC50 为 1.6 μ;M 代表 PTP1B,400 nM 代表 IKK-β;EC50 约为 1 μ;M 代表 PPARα;/PPAR`; -
GC33791
Isotanshinone IIA
异丹参酮IIA
IsotanshinoneIIA,一个松香型二萜代谢物,能够抑制蛋白酪氨酸磷酸酶1B(PTP1B)的活性,其IC50值为11.4μM。
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GC33345
BN82002
BN82002是CDC25磷酸酶的合成抑制剂,其对重组CDC25磷酸酶的IC50值为2.4-6.3μM。
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GC33227
F1063-0967
A DUSP26 inhibitor
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GC33059
3α-Aminocholestane
3α-氨基胆甾烷
An inhibitor of SHP-1 -
GC33044
RMC-4550
A SHP-2 inhibitor
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GC32852
LTV-1
LTV-1是一种高效的,可逆的淋巴酪氨酸磷酸酶(LYP)抑制剂(IC50=508nM)。
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GC32783
Rosiptor (AQX-1125)
罗西普托,AQX-1125
Rosiptor (AQX-1125) (AQX-1125) 是一种具有抗炎作用的选择性和口服活性磷酸酶 SHIP1 激活剂。 Rosiptor (AQX-1125) (AQX-1125) 在体外抑制 Akt 磷酸化、炎症介质产生和白细胞趋化性。 -
GC32709
Stibogluconate sodium (Sodium stibogluconate)
葡萄糖酸锑钠; Stibogluconate trisodium nonahydrate
An anti-Leishmania antimony derivative