phosphatases(磷酸酶)
Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.
Products for phosphatases
- Cat.No. 产品名称 Information
- GC32397 MSI-1436 lactate (Trodusquemine lactate) MSI-1436 lactate (Trodusquemine lactate) 是一种选择性的、非竞争性的蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂,IC50 为 1 μM,比 TCPTP 高 200 倍(IC50 为 224 μM )。
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GC32396
MSI-1436 (Trodusquemine)
MSI-1436 (Trodusquemine) 是一种选择性的、非竞争性的蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂,其 IC50 约为 1 μM,比 TCPTP 高 200 倍 (IC50, 224 μM) .
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GC31772
Tautomycin
Tautomycin是可从Streptomycesverticillatus中分离得到的一种真菌类抗生素,是蛋白磷酸酶1和2A的有效特异性抑制剂,在没有Ca2+的情况下诱导平滑肌收缩,Kiapp值分别为0.16nM和0.4nM。
- GC31635 PTP1B-IN-3 PTP1B-IN-3是有效的,有选择性的PTP1B抑制剂。IC50值为120nM(PTP1B)和120nM(TCPTP)。
- GC31499 JTT 551 JTT551是一种选择性的蛋白酪氨酸磷酸酶1B(PTP1B)抑制剂,Ki值为0.22μM,同时对T细胞蛋白酪氨酸磷酸酶(TCPTP)也有作用,Ki值为9.3μM,可用于二型糖尿病的研究。
- GC31324 PTP1B-IN-2 A PTP1B inhibitor
- GC30834 Rilapladib (SB 659032) Rilapladib (SB 659032) (SB 659032) 是一种选择性 Lp-PLA2(脂蛋白相关磷脂酶 A2)抑制剂,IC50 为 230 pM。
- GC30754 SHP2 IN-1 SHP2IN-1(compound13)是SHP2(PTPN11)的变构抑制剂,其IC50值为3nM。
- GC30664 Enocyanin Enocyanin是从葡萄中得到的花青素。Enocyanin可影响亮氨酸氨基肽酶、酸性磷酸酶(acidphosphatase)、γ-谷氨酰转肽酶和酯酶的活性。
- GC19331 SHP099 hydrochloride An orally bioavailable inhibitor of SHP2
- GC19223 LMPTP INHIBITOR 1 dihydrochloride An LMW-PTP inhibitor
- GC18859 Microcystin-LA A potent protein phosphatase inhibitor
- GC18718 bpV(pic) (potassium hydrate) A PTEN inhibitor
- GC18575 2-hydroxy Tricosanoic Acid methyl ester A hydroxy fatty acid methyl ester
- GC18258 CpdA A non-steroidal selective glucocorticoid receptor modulator
- GC18239 TPI-1 An inhibitor of protein tyrosine phosphatases
- GC10594 Sodium Fluoride 酸性磷酸酶抑制剂
- GC12306 Imidazole 咪唑是一个平面五元环。
- GC12093 Sodium tartrate 酒石酸钠是一种具有抗氧化活性的 pH 调节剂。
- GC16396 Sodium molybdate 钼酸钠(钼酸二钠)是一种有用的钼酸盐来源。
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GC11806
β-Glycerophosphate (sodium salt hydrate)
An inhibitor of alkaline phosphatase
- GC10850 ML-095 (hydrochloride) A PLAP inhibitor
- GC12189 LB-100 A PP2A inhibitor with anticancer activity
- GC10019 SF1670 A selective PTEN inhibitor
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GC14520
(-)-p-Bromotetramisole Oxalate
(-)-p-Bromotetramisole Oxalate是强效的非特异性的碱性磷酸酶抑制剂。
- GC16451 L-690,330 L-690,330 是一种肌醇单磷酸酶 (IMPase) 的竞争性抑制剂,对重组人和牛 IMPase 的 Kis 分别为 0.27 和 0.19 μM,对人和牛额叶皮层 IMPase 的 Kis 分别为 0.30 和 0.42 μM。
- GC13516 AS 1949490 A selective SHIP2 inhibitor
- GC11561 NSC 95397 An irreversible inhibitor of Cdc25 isoforms
- GC14875 NSC 663284 Inhibitor of Cdc25 isoforms
- GC17591 D-erythro-Sphingosine (synthetic) A pharmacological tool to probe the activity of protein kinase C
- GC17995 Tacrolimus monohydrate 他克莫司一水合物 (FK506 monohydrate) 是一种大环内酯,与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶,从而抑制 T 淋巴细胞信号转导和 IL-2 转录。
- GC11352 Tetramisole HCl Tetramisole HCl 是一种碱性磷酸酶抑制剂,是一种高纯度的抗寄生虫药。
- GC12880 GSK 2830371 An inhibitor of Wip1 phosphatase
- GC17331 Salubrinal An inhibitor of eIF2α dephosphorylation
- GC16233 Tacrolimus (FK506) A potent immunosuppressant/inhibitor of T cell activation
- GC14368 Sodium Orthovanadate A protein tyrosine phosphatase inhibitor
- GC12020 TCS 401 A selective PTP1B inhibitor
- GC10169 NSC 87877 A potent inhibitor of SHP-1 and SHP-2
- GC16256 BVT 948 An inhibitor of protein tyrosine phosphatases
- GC14321 Sal 003 An inhibitor of eIF2α dephosphorylation
- GC18106 Calyculin A Potent inhibitor of PP1 and PP2A
- GN10140 Silydianin 水飞蓟素是水飞蓟的活性成分,具有抗胶原酶、抗肿瘤和抗弹性蛋白酶活性。 Silydianin 是一种天然蛋白质酪氨酸磷酸酶 1B (PTP1B),IC50 为 17.38 μM。水飞蓟素对体外氧化产物的产生和释放具有抑制作用。