SGLT(钠-葡萄糖协同转运蛋白)
SGLT (sodium-glucose linked transporter) uses the energy from the downhill sodium ion gradient created by the ATPase pump to transport glucose across the apical membrane against an uphill glucose gradient.
- Cat.No. 产品名称 Information
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GC70113
Velagliflozin proline
Velagliflozin proline 是一种可口服的钠-葡萄糖协同转运蛋白 2 (SGLT2) 抑制剂,具有抗糖尿病的活性。 特别是,Velagliflozin proline 减少肾葡萄糖重吸收,促进葡萄糖尿,从而降低血糖和胰岛素浓度。
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GC69241
HSK0935
HSK0935是高效,高选择性,口服可用的 SGLT2 抑制剂。IC50为1.3 nM。具有抗高血糖功效。
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GC64266
Enavogliflozin
Enavogliflozin (DWP-16001) 作为一种抗糖尿病药物,是一种具有口服活性,一流的选择性钠-葡萄糖协同转运体 -2 (SGLT-2) 抑制剂。
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GC60249
Mizagliflozin
Mizagliflozin (KWA 0711) is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation.
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GC39178
Canagliflozin D4
An internal standard for the quantification of canagliflozin
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GC36498
LX2761
LX2761 在体外是一种化学稳定性和有效性的钠依赖性葡萄糖协同转运蛋白1 (SGLT1) 和 SGLT2 抑制剂,对hSGLT1 和 hSGLT2 的 IC50 值分别为 2.2 nM 和 2.7 nM,但在胃肠道 (GI) 表现出特定的 SGLT1 抑制作用。
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GC36326
Ipragliflozin L-Proline
Ipragliflozin L-Proline is an orally active and selective inhibitor of SGLT2 with IC50 of 7.38 nM, 6.73 nM and 5.64 nM for human SGLT2, rat SGLT2 and mouse SGLT2, respectively.
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GC36004
Ertugliflozin L-pyroglutamic acid
Ertugliflozin (MK-8835, PF-04971729) L-pyroglutamic acid is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2) with IC50 of 0.877 nM for h-SGLT2. Ertugliflozin has the potential for the treatment of type 2 diabetes mellitus.
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GC35809
Dapagliflozin ((2S)-1,2-propanediol, hydrate)
Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors.
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GC35603
Canagliflozin hemihydrate
An inhibitor of SGLT2
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GC41374
Trilobatin
A dihydrochalcone glucoside with diverse biological activities
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GC31593
Velagliflozin
Velagliflozin是一种可口服的钠-葡萄糖协同转运蛋白2(SGLT2)抑制剂,具有抗糖尿病的活性。
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GC31461
Tofogliflozin (CSG452)
Tofogliflozin (CSG 452) is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and hSGLT1, respectively.
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GC31377
Tofogliflozin hydrate (CSG-452 hydrate)
A potent inhibitor of SGLT2
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GC31366
Licogliflozin (LIK066)
Licogliflozin (LIK066) 是一种钠葡萄糖协同转运蛋白(SGLT1 和 SGLT2)抑制剂。
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GC19065
Bexagliflozin
A SGLT2 inhibitor
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GC17190
galacto-Dapagliflozin
A potent inhibitor of hSGLT2
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GC16697
fluoro-Dapagliflozin
A potent inhibitor of hSGLT2
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GC16469
Ipragliflozin
An SGLT2 inhibitor
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GC13771
Canagliflozin
An inhibitor of SGLT2
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GC15530
Dapagliflozin
An SGLT2 inhibitor
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GC16212
Empagliflozin (BI 10773)
An SGLT2 inhibitor
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GC17976
Phloretin
A natural inhibitor of various transporters
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GC16012
PF-04971729
An SGLT2 inhibitor
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GC15088
LX-4211
An SGLT inhibitor
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GN10029
Phloridzin
An inhibitor of sodium-glucose cotransporters