SGLT(钠-葡萄糖协同转运蛋白)

SGLT (sodium-glucose linked transporter) uses the energy from the downhill sodium ion gradient created by the ATPase pump to transport glucose across the apical membrane against an uphill glucose gradient.

Products for SGLT

Cat.No. 产品名称 Information
GC70113 Velagliflozin proline Velagliflozin proline 是一种可口服的钠-葡萄糖协同转运蛋白 2 (SGLT2) 抑制剂，具有抗糖尿病的活性。特别是，Velagliflozin proline 减少肾葡萄糖重吸收，促进葡萄糖尿，从而降低血糖和胰岛素浓度。
GC69241 HSK0935 HSK0935是高效，高选择性，口服可用的 SGLT2 抑制剂。IC50为1.3 nM。具有抗高血糖功效。
GC64266 Enavogliflozin
DWP-16001
Enavogliflozin (DWP-16001) 作为一种抗糖尿病药物，是一种具有口服活性，一流的选择性钠-葡萄糖协同转运体 -2 (SGLT-2) 抑制剂。
GC60249 Mizagliflozin
DSP-3235 free base; KGA-3235 free base; GSK-1614235 free base
Mizagliflozin (KWA 0711) is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation.
GC39178 Canagliflozin D4
卡格列净D4,JNJ 28431754-d4
An internal standard for the quantification of canagliflozin
GC36498 LX2761 LX2761 在体外是一种化学稳定性和有效性的钠依赖性葡萄糖协同转运蛋白1 (SGLT1) 和 SGLT2 抑制剂，对hSGLT1 和 hSGLT2 的 IC50 值分别为 2.2 nM 和 2.7 nM，但在胃肠道 (GI) 表现出特定的 SGLT1 抑制作用。
GC36326 Ipragliflozin L-Proline
L-脯氨酸与(1S)-1,5-脱水-1-C-[3-(苯并[B]噻吩-2-基甲基)-4-氟苯基]-D-山梨糖醇的化合物
Ipragliflozin L-Proline is an orally active and selective inhibitor of SGLT2 with IC50 of 7.38 nM, 6.73 nM and 5.64 nM for human SGLT2, rat SGLT2 and mouse SGLT2, respectively.
GC36004 Ertugliflozin L-pyroglutamic acid
埃格列净,PF-04971729 L-pyroglutamic acid
Ertugliflozin (MK-8835, PF-04971729) L-pyroglutamic acid is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2) with IC50 of 0.877 nM for h-SGLT2. Ertugliflozin has the potential for the treatment of type 2 diabetes mellitus.
GC35809 Dapagliflozin ((2S)-1,2-propanediol, hydrate)
达格列净一水丙二醇,BMS-512148 (2S)-1,2-propanediol, hydrate
Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors.
GC35603 Canagliflozin hemihydrate
卡格列净半水合物,JNJ 28431754 hemihydrate
An inhibitor of SGLT2
GC41374 Trilobatin
三叶苷
A dihydrochalcone glucoside with diverse biological activities
GC31593 Velagliflozin
Velagliflozin是一种可口服的钠-葡萄糖协同转运蛋白2(SGLT2)抑制剂，具有抗糖尿病的活性。
GC31461 Tofogliflozin (CSG452)
托格列净,CSG452
Tofogliflozin (CSG 452) is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and hSGLT1, respectively.
GC31377 Tofogliflozin hydrate (CSG-452 hydrate)
托格列净,CSG-452 hydrate
A potent inhibitor of SGLT2
GC31366 Licogliflozin (LIK066)
LIK066
Licogliflozin (LIK066) 是一种钠葡萄糖协同转运蛋白（SGLT1 和 SGLT2）抑制剂。
GC19065 Bexagliflozin
(1S)-1,5-脱水-1-C-[4-氯-3-[[4-[2-(环丙氧基)乙氧基]苯基]甲基]苯基]-D-山梨醇
A SGLT2 inhibitor
GC17190 galacto-Dapagliflozin A potent inhibitor of hSGLT2
GC16697 fluoro-Dapagliflozin
flouro-DAPA
A potent inhibitor of hSGLT2
GC16469 Ipragliflozin
伊格列净; ASP1941
An SGLT2 inhibitor
GC13771 Canagliflozin
卡格列净; JNJ 28431754
An inhibitor of SGLT2
GC15530 Dapagliflozin
达格列净; BMS-512148
An SGLT2 inhibitor
GC16212 Empagliflozin (BI 10773)
恩格列净; BI 10773
An SGLT2 inhibitor
GC17976 Phloretin
根皮素; NSC 407292; RJC 02792
A natural inhibitor of various transporters
GC16012 PF-04971729
埃格列净; PF-04971729
An SGLT2 inhibitor
GC15088 LX-4211
索格列净,LX4211;LX 4211
An SGLT inhibitor
GN10029 Phloridzin
根皮苷; Floridzin; NSC 2833
An inhibitor of sodium-glucose cotransporters