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CETP (cholesteryl ester transfer protein) is a hydrophobic glycoprotein consisting of 476 amino acids residue that, in general, facilitates the transfer of neutral lipids (such as cholesteryl and triglycerides) among lipoprotein particles. The chemical structure of CETP takes on a shape of a boomerang in which a long hydrophobic tunnel with openings at either end allows lipids to be exchanged between donor and acceptor lipoproteins in a non-aqueous phase. Study results suggest that CETP facilitates the transfer of cholesteryl esters from HDL to LDL and VLDL resulting in the lowering of HDL levels and raising of LDL and VDL levels, which might increase the risk of cardiovascular disease.

  1. Cat.No. 产品名称 Information
  2. GC50257 BMS 795311 BMS 795311 是一种有效的可口服生物利用的胆固醇酯转移蛋白 (CETP) 抑制剂,在基于酶的闪烁邻近试验 (SPA) 中的 IC50 为 4 nM,在人全血浆试验 (hWPA) 中的 IC50 分别为 0.22 μM。
  3. GC38759 CP-532623
  4. GC37736 TAP311
  5. GC35657 CETP-IN-3
  6. GC15848 Torcetrapib A CETP inhibitor
  7. GC14061 Evacetrapib (LY2484595) A CETP inhibitor
  8. GC13856 Dalcetrapib (JTT-705, RO4607381) An inhibitor of cholesteryl ester transfer protein
  9. GC17520 Anacetrapib (MK-0859) A CETP inhibitor

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