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Factor Xa(凝血因子 Xa)

Factor Xa is a trypsin-like serine protease that catalyzes the cleavage of peptide bonds on the carboxyl side (P’1) of a basic amino acid residue with a preference to cleave peptide bonds of carboxyl function provided by an argininyl residue. Factor Xa plays an essential role in the coagulation cascade catalyzing the conversion of prothrombin to thrombin on surface of vascular cells to link the extrinsic and intrinsic pathways, in which it forms the Ca2+- and phospholipid-dependent prothrombinase complex with cofactor V/Va on activated platelets, monocytes or endothelial cells. Moreover, factor Xa has been found to mediate the stimulation of lymphocyte proliferation, induce the mitogenesis of endothelial and smooth muscle cells, and trigger acute inflammatory responses in vivo.

  1. Cat.No. 产品名称 Information
  2. GC25137 Betrixaban maleate Betrixaban maleate is the maleate salt form of Betrixaban, which is a Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation.
  3. GC65912 Asundexian
  4. GC65060 Fitusiran
  5. GC63873 Milvexian
  6. GC49684 Dabigatran-13C-d3 An internal standard for the quantification of dabigatran
  7. GC49682 Dabigatran-d3 An internal standard for the quantification of dabigatran
  8. GC49614 Acenocoumarol-d4 Acenocoumarol-d4 是氘标记的 Acenocoumarol。
  9. GC49518 Fluindione A vitamin K antagonist
  10. GC62922 Darexaban
  11. GC49322 GGACK (hydrochloride) A uPA and factor Xa inhibitor
  12. GC49131 Dehydro Warfarin A metabolite of (±)-warfarin
  13. GC49118 10-hydroxy Warfarin A metabolite of (R)-warfarin
  14. GC62439 Edoxaban impurity 6
  15. GC62298 Edoxaban impurity 4
  16. GC19766 Heparin sodium salt (MW 15kDa) 肝素钠盐(MW 15kDa)(Sodium heparin (MW 15kDa))是肝素的聚合物,分子量为15kDa。
  17. GC61748 Betrixaban D6
  18. GC47280 Edoxaban-d6 An internal standard for the quantification of edoxaban
  19. GC46879 Argatroban-d3 (hydrochloride) An internal standard for the quantification of argatroban
  20. GC46863 Apixaban-13C-d3 An internal standard for the quantification of apixaban
  21. GC60326 Rivaroxaban D4 An internal standard for the quantification of rivaroxaban
  22. GC36831 Ozagrel sodium A selective inhibitor of TXA synthase
  23. GC36092 FXIa-IN-1
  24. GC35962 Edoxaban tosylate A potent inhibitor of Factor Xa
  25. GC35536 BMS-962212
  26. GC44966 Sucrose octasulfate (potassium salt) An alkaline aluminum?sucrose complex
  27. GC43696 Fondaparinux (sodium salt) An inhibitor of Factor Xa
  28. GC32614 BMS-654457
  29. GC32567 RWJ-445167 (3DP-10017)
  30. GC17799 Betrixaban A Factor Xa inhibitor
  31. GC17726 Otamixaban Otamixaban(FXV673) 是一种有效的 (Ki = 0.5 nM)、选择性、快速作用、竞争性和可逆的 fXa 抑制剂,可有效抑制游离和凝血酶原结合的 fXa。
  32. GC12839 Edoxaban tosylate monohydrate A potent inhibitor of Factor Xa
  33. GC11644 Edoxaban Edoxaban (DU-176b) 是一种具有口服活性、高效、选择性和直接的因子 Xa (FXa) 抑制剂,对游离人 FXa 和凝血酶原酶的 Ki 值分别为 0.561 和 2.98 nM。
  34. GC11101 5-R-Rivaroxaban 5-R-Rivaroxaban 是 Rivaroxaban 的 (R)-对映异构体。
  35. GC15757 Ozagrel A selective inhibitor of TXA synthase
  36. GC13130 Apixaban An inhibitor of Factor Xa
  37. GC13683 Rivaroxaban A selective inhibitor of Factor Xa
  38. GC13711 Gabexate mesylate A serine protease inhibitor

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