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Procollagen C Proteinase(前胶原C端蛋白酶)

The procollagen C-proteinase is a member of the subfamily Astacin of the family M12 (Astacin) of clan MB of metalloproteinases that specifically cleaves an Ala-Asp bond in type I/II procollagens, a Gly-Asp bond in type III procollage, and similar bonds in a precursor of lysyloxidase as well as in laminin 5. Three procollagen C-proteinase proteins encoded by different open reading frames (ORFs) of the same gene have been identified, including a 70 kDa polypeptide referred to as bone morphogenetic protein/C-proteinase (BMP-1/C-proteinase) or pCP1, an 80 kDa polypeptide referred to as bone morphogenetic protein/His (BMP-1/His) and a 100 kDa polypeptide referred to as mammalian tolloid (mTld) or pCP-2.

  1. Cat.No. 产品名称 Information
  2. GC11366 UK 383367 UK 383367 (UK 383367) 是一种有效的选择性 BMP-1(前胶原 C 蛋白酶)抑制剂,IC50 为 44 nM;对 BMP-1 的选择性优于 MMP 1、2、3、9 和 14(列出的 MMP 的 IC50 值 \u003e10,000 nM)。

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