Home >> Signaling Pathways >> Metabolism >> Pyruvate kinase

Pyruvate kinase(丙酮酸激酶)

Pyruvate kinase is an enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP in glycolysis and plays a role in regulating cell metabolism. There are four mammalian pyruvate kinase isoforms (PKM1, PKM2, PKR, PKL), and each isoform has had multiple designations over time in the literature. The M2 isoform of pyruvate kinase (PKM2) supports anabolic metabolism and is expressed both in cancer and normal tissue. The enzymatic activity of PKM2 is allosterically regulated by both intracellular signaling pathways and metabolites; PKM2 thus integrates signaling and metabolic inputs to modulate glucose metabolism according to the needs of the cell.

Products for  Pyruvate kinase

  1. Cat.No. 产品名称 Information
  2. GC69796 (Rac)-Etavopivat


    (Rac)-Etavopivat((Rac)-FT-4202) 是Etavopivat 异构体。Etavopivat 是一种具有口服活性的的红细胞丙酮酸激酶-R (PKR) 激活剂,可以用于镰状细胞病和其他血红蛋白疾病研究。
  3. GC69716 PKM2 activator 2 PKM2 activator 2 是一种具有抗增殖作用的丙酮酸激酶 M2 (PKM2) 激活剂,AC50 为 66 nM。PKM2 activator 2 可能具有抗肿瘤增殖作用,并缓解 Warburg 效应,因为 PKM2 激活可使细胞恢复正常糖酵解代谢状态。
  4. GC64428 Etavopivat


    Etavopivat 是一种有效的、选择性的、口服生物可利用的红细胞 (RBC) 丙酮酸激酶 (PKR) 激活剂,具有有效的抗镰刀化作用。
  5. GC32738 PKM2-IN-1

    Compound 3K, MDK4882, PKM2-IN-1, Pyruvate Kinase M2 Inhibitor

    PKM2-IN-1 是一种丙酮酸激酶 M2 (PKM2) 抑制剂,IC50 为 2.95 μM。
  6. GC19297 Mitapivat


    Mitapivat (AG-348) 是一种具有口服活性的丙酮酸激酶变构激活剂。
  7. GC11741 ML-265


    A selective PKM2 activator
  8. GC12888 DASA-58


    A selective PKM2 activator
  9. GN10216 Shikonin

    紫草素; C.I. 75535; Isoarnebin 4

    A natural product with anti-inflammatory and anti-tumor activity

8 Item(s)

per page

Set Descending Direction