Metabolism(代谢)

Cat.No. 产品名称 Information

GC36023 FAAH inhibitor 1

Benzothiazole analog 3

FAAH inhibitor 1是脂肪酸酰胺水解酶（FAAH）抑制剂，IC50为18 nM。

GC36011 Ethylenediaminetetraacetic acid trisodium salt

依地酸三钠盐; EDTA trisodium salt; Trisodium EDTA

Ethylenediaminetetraacetic acid (EDTA) is a chelating agent commonly used in protein purification, both to eliminate contaminating divalent cations and to inhibit protease activity.

GC36004 Ertugliflozin L-pyroglutamic acid

埃格列净,PF-04971729 L-pyroglutamic acid

Ertugliflozin (MK-8835, PF-04971729) L-pyroglutamic acid is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2) with IC50 of 0.877 nM for h-SGLT2. Ertugliflozin has the potential for the treatment of type 2 diabetes mellitus.

GC35981 EMT inhibitor-2 EMT inhibitor-2 (Compound 1) 抑制由免疫细胞释放的物质如 IL-1β 和 TGF-β 诱导的上皮-间质转化 (EMT)。EMT inhibitor-2 抑制CYP3A4 睾酮和 CYP2C9，IC50 分别为 49.72 和 5.54 μM。

GC35962 Edoxaban tosylate

依度沙班对甲苯磺酸盐; DU-176b

A potent inhibitor of Factor Xa

GC35876 DL-Glutamine

DL-谷氨酰胺; (±)-Glutamine; DL-Gl

DL-Glutamine (Glutamin, 2-amino-4-carbamoylbutanoic acid) is a non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes.

GC35838 Deltasonamide 2 hydrochloride Deltasonamide 2 hydrochloride 是一种竞争性的，高亲和力的 PDEδ 抑制剂，Kd 值为 ~385 pM.

GC35837 Deltasonamide 2 (TFA) Deltasonamide 2 TFA 是一种竞争性的，高亲和力的 PDEδ 抑制剂，Kd 值约为 385 pM。

GC35809 Dapagliflozin ((2S)-1,2-propanediol, hydrate)

达格列净一水丙二醇,BMS-512148 (2S)-1,2-propanediol, hydrate

Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors.

GC35803 Dafadine-A Dafadine-A是dafadine类似物，是C. elegans DAF-9 细胞色素P450抑制剂，还能抑制哺乳动物的CYP27A1。

GC35795 D,L-Buthionine-(S,R)-sulfoximine hydrochloride

Buthionine sulfoximine hydrochloride; BSO hydrochloride

A γ-glutamylcysteine synthetase inhibitor

GC35791 cyt-PTPε Inhibitor-1 cyt-PTPε Inhibitor-1 是一种有效的胞质蛋白酪氨酸磷酸酶 cyt-PTPε 抑制剂，与 cyt-PTPε 的催化结构域结合，抑制 c-Src 的活化 (c-Src 去磷酸化)，具有抗破骨细胞的活性。

GC35788 CYP17-IN-1 CYP17-IN-1 (compound 9c) 是一种有效的，具有口服活性的 CYP17 的抑制剂，对大鼠和人 CYP17 的 IC50 值为 15.8 和 20.1 nM。

GC35757 Cucurbitacin D

葫芦素 D

A triterpenoid with diverse biological activities

GC35698 Ciprofibrate D6

环丙贝特 D6

An internal standard for the quantification of ciprofibrate

GC35692 Chrysosplenetin

猫眼草黄素

A flavonoid with diverse biological activities

GC35657 CETP-IN-3 CETP-IN-3 (Compound 13) 是血浆糖蛋白胆固醇酯转移蛋白 (CETP) 的小分子抑制剂，可抑制 CETP 活性并提高高密度脂蛋白胆固醇 (HDL-C) 水平。CETP-IN-3 抑制活力的IC50 值分别为0.002 μM (SPA), 0.06 μM (WPA) 。

GC35627 CDC25B-IN-1 CDC25B-IN-1 (compound 4a) 是一种有效的细胞分裂周期 25B (CDC25B) 磷酸酶抑制剂，其 Ki 值为 8.5 μM。CDC25B-IN-1 能有效抑制细胞增殖和克隆形成，导致 G2/M 期停滞。

GC35603 Canagliflozin hemihydrate

卡格列净半水合物,JNJ 28431754 hemihydrate

An inhibitor of SGLT2

GC35565 Bucladesine calcium salt

二丁酰环磷腺苷钙,Dibutyryl cAMP calcium salt; DBcAMP calcium salt

Bucladesine 钙盐（Dibutyryl-cAMP 钙盐；DC2797 钙盐）是一种细胞可渗透的环 AMP (cAMP) 类似物，可通过增加细胞内 cAMP 水平选择性地激活 cAMP 依赖性蛋白激酶 (PKA)。

GC35543 BPN14770

BPN14770

Zatolmilast (BPN14770) is a selective allosteric inhibitor of phosphodiesterase 4D (PDE4D) with IC50 of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively.

GC35536 BMS-962212 BMS-962212 是直接的，可逆的，选择性 FXIa 抑制剂。 BMS-962212 具有良好的耐受性，快速起效的药效 (PD) 反应和快速消除。 BMS-962212 在活化的部分促凝血酶原激酶时间内依赖性地增加暴露，并且在 FXI 凝血活性中依赖性地降低暴露。

GC35518 Bilobetin

白果素

A biflavonoid with diverse biological activities

GC35499 Bestatin trifluoroacetate

乌苯美司三氟乙酸盐; Ubenimex trifluoroacetate

An aminopeptidase inhibitor

GC35419 Atorvastatin

阿托伐他汀

阿托伐他汀（Atorvastatin）是一种口服活性HMG-CoA还原酶抑制剂，可以有效降低血脂

GC35399 Artefenomel

OZ439

An antimalarial agent

GC35398 Arteannuin B

青蒿素B

A precursor to artemisinin with diverse biological activities

GC35390 Aristolochic acid C

马兜铃酸 C

An alkaloid with anticancer activity

GC35371 AP-III-a4 hydrochloride

ENOblock hydrochloride

A small molecule enolase inhibitor

GC35358 Ankaflavin

红曲黄素

Ankaflavin 是从Monascus-Fermented 红米中提取得到的，是PPARγ 的激动剂，具有抗炎活性。Ankaflavin 具有选择性的细胞毒性作用，诱导癌细胞死亡。

GC35349 Angeloylgomisin H

当归酰戈米辛 H

Angeloylgomisin H 是一种木脂素类化合物，可从五味子 (Schisandra rubriflora) 中提取。Angeloylgomisin H 通过激活 PPAR-γ 来改善胰岛素刺激的葡萄糖摄取潜力。

GC35308 Alpinetin

山姜素

Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities. Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata, activates activates PPAR-γ, with potent anti-inflammatory activity.