Metabolism(代谢)

Cat.No. 产品名称 Information

GC49100 Desmethyl Ofloxacin (hydrochloride) A metabolite of ofloxacin

GC49096 Cobaltic Protoporphyrin IX (chloride)

原卟啉氯化钴

An inducer of HO-1 activity

GC49087 Clofibric Acid-d4

Chlorofibrinic acid-d4

An internal standard for the quantification of clofibric acid

GC49085 Brombuterol (hydrochloride)

溴布特罗盐酸盐,Bromobuterol hydrochloride

A β2-AR agonist

GC49083 N,N’-Diphenethylurea

1,3-Diphenethylurea, NSC 25433

A bacterial metabolite with diverse biological activities

GC49079 C82 An Mtb CdnP inhibitor

GC49074 Forphenicine A bacterial metabolite and an inhibitor of alkaline phosphatase

GC49061 Pam2CSK4 (trifluoroacetate salt)

Pam2Cys-Ser-(Lys)4

A bacterial lipopeptide and TLR2 agonist

GC49058 DTPA

二乙烯三胺五醋酸,Diethylenetriaminepentaacetic acid; DTPA

A cell-impermeable metal chelating agent

GC49055 Tebuconazole-d9

戊唑醇 d9

An internal standard for the quantification of tebuconazole

GC49051 7-hydroxy Methotrexate

7-羟基甲氨蝶呤

A metabolite of methotrexate

GC49044 Benastatin C A bacterial metabolite with diverse biological activities

GC49034 1(R)-(Trifluoromethyl)oleyl alcohol An oleic acid analog

GC49032 Taurohyodeoxycholic Acid MaxSpec® Standard

牛磺猪去氧胆酸

A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications

GC49030 7-Ethoxycoumarin

7-乙氧基香豆素; 7-O-Ethylumbelliferone

A CYP450 substrate

GC49025 Desogestrel-13C2-d2 An internal standard for the quantification of desogestrel

GC49024 Palmitic Acid MaxSpec® Standard

棕榈酸

A long-chain saturated fatty acid

GC49023 Palmitic Acid-d9 MaxSpec® Standard

棕榈酸-13,13,14,14,15,15,16,16,16-D9

A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications

GC49022 Didanosine-d2

去羟肌苷 d2

An internal standard for the quantification of didanosine

GC49020 Levomefolate-13C-d3

L-Methyl Folate-13C-d3, 6S-5-Methyltetrahydrofolate-13C-d3, 6S-5-MTHF-13C-d3

An internal standard for the quantification of levomefolate

GC49017 8-hydroxy Amoxapine A metabolite of amoxapine

GC49016 Dimethyl 2-ketoglutarate

alpha-酮戊二酸二甲酯

An esterified form of α-ketoglutarate

GC49012 Tauro-β-muricholic Acid-d4 (sodium salt)

Tauro-β-muricholate-d4, TβMCA-d4

tauro-β-muricholic acid 定量的内标

GC49011 Tauro-α-muricholic Acid-d4 (sodium salt)

Tauro-β-muricholate-d4, TβMCA-d4

An internal standard for the quantification of tauro-α-muricholic acid

GC49010 Taurohyocholic Acid-d4 (sodium salt)

Taurine Hyocholate-d4, Tauro-γ-muricholic Acid-d4, Taurohyocholate-d4, THCA-d4

An internal standard for the quantification of taurohyocholic acid

GC49009 ω-Muricholic Acid-d4

ω-MCA-d4

An internal standard for the quantification of ω-MCA

GC49008 α-Muricholic Acid-d4

ω-MCA-d4

An internal standard for the quantification of α-muricholic acid

GC49007 β-Muricholic Acid-d4

ω-MCA-d4

An internal standard for the quantification of β-muricholic acid

GC49006 Glycohyocholic Acid-d4

Glycine hyocholate-d4

An internal standard for the quantification of glycohyocholic acid

GC48996 Phenylacetyl-Coenzyme A (sodium salt)

Phenylacetyl-CoA

A key intermediate in aerobic catabolism of phenylacetate in bacteria

GC48994 Girard’s Reagent P-d5

Girard P hydrazine-d5, GirP-d5, GP-d5

An internal standard for the quantification of Girard's reagent P

GC48991 UDP-Glucuronic Acid (sodium salt hydrate)

UDPGA, UDP-GlcA, Uridine-5'-diphosphoglucuronic Acid

核苷二磷酸糖

GC48990 UDP-N-acetyl-D-Glucosamine (sodium salt hydrate)

UDPAG, UDP-GlcNAc, Uridine-5'-diphosphate-N-acetyl-D-Glucosamine

A nucleotide sugar

GC48989 LTX-315 (trifluoroacetate salt) A synthetic cationic amphiphilic peptide

GC48979 Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate)

E217G, βEstradiol 17(βDGlucuronide), 17βEstradiol 17(βDGlucuronide), 17βOestradiol 17(βDGlucuronide)

A substrate of multidrug resistance protein 2

GC48977 Taurodeoxycholic Acid (sodium salt hydrate)

牛磺脱氧胆酸钠水合物

A taurine-conjugated form of deoxycholic acid

GC48976 UDP-α-D-Glucose (sodium salt hydrate)

UDPG, UDP-Glucose, Uridine5'diphosphoglucose

A P2Y₁₄ agonist

GC62711 BAMEA-O16B BAMEA-O16B 是一种脂质纳米颗粒。BAMEA-O16B 结合了二硫键，可以有效地将 Cas9 mRNA 和 sgRNA 传递到细胞中，同时响应细胞内还原环境释放 RNA 进行基因组编辑。BAMEA-O16B 可用于基因编辑的研究。

GC62689 PROTAC IDO1 Degrader-1 PROTAC IDO1 Degrader-1 是第一个强效的 IDO1 (indoleamine 2,3-dioxygenase 1) 降解剂，它将IDO1劫持到crbne3连接酶上，最终实现泛素化和降解 (DC50=2.84 μM)。PROTAC-IDO1降解剂-1适度提高H-ER2-CAR-T细胞的杀伤活性。

GC62643 L-Buthionine-(S,R)-sulfoximine hydrochloride

L-Buthionine sulfoximine hydrochloride; L-BSO hydrochloride

An irreversible inhibitor of the γ-glutamylcysteine synthetase

GC62589 Difamilast

OPA-15406

Difamilast (OPA-15406) 是一种局部的，具有选择性的非甾体磷酸二酯酶 4 (PDE4) 抑制剂，对 B 亚型具有特别有效的抑制作用 (IC50=11.2 nM)。Difamilast 可用于研究轻度至中度特应性皮炎 (AD)。

GC62571 IPI-9119 IPI-9119 is a potent, selective, and irreversible inhibitor of fatty acid synthase (FASN), which can inhibit the FASN thioesterase domain by promoting acylation of the catalytic serine with an IC50 of 0.3 nM.

GC62525 LEO 39652 LEO 39652 是一种 dual-soft PDE4 抑制剂，对于 PDE4A 的 IC50 值为 1.2 nM，对于 PDE4B 的 IC50 值为 1.2 nM，对于 PDE4C 的 IC50 值为 3.0 nM，对于 PDE4D 的 IC50 值为 3.8 nM。LEO 39652 还抑制 TNF-α，IC50 值为 6.0 nM。LEO 39652 用于局部研究特应性皮炎。

GC62496 BMS-986242 BMS-986242 是一种具有口服活性、强效和选择性的 indoleamine-2,3-dioxygenase 1 (IDO1) 抑制剂。BMS-986242 可用于癌症研究。

GC62491 BMS-986202 BMS-986202 是一种有效的，选择性的，具有口服活性的 Tyk2 抑制剂，可与 Tyk2 JH2 结合，IC50 为 0.19 nM，Ki 为 0.02 nM。BMS-986202 对包括 Jak 家族成员在内的其他激酶具有高度选择性。BMS-986202 还是 CYP2C19 的弱抑制剂，IC50 为 14 μM。BMS-986202 可用于 IL-23 驱动的棘皮症，抗 CD40 诱导的结肠炎和自发性狼疮的研究。

GC62487 POMHEX POMHEX 是一个消旋混合物，是具有细胞渗透性的 HEX 的 POM 前体药物，是ENO2 的特异性抑制剂。POMHEX 对ENO1 缺失的细胞表现出低纳摩尔级别活性，并对 ENO1 缺失的肿瘤模型表现出良好的抗癌效果。POMHEX 是有效的糖酵解抑制剂。

GC62476 Nampt-IN-5 Nampt-IN-5 是一种有效的烟酰胺磷酸核糖基转移酶 (NAMPT) 抑制剂。Nampt-IN-5 还抑制 CYP3A4 活性。Nampt-IN-5 可抑制 A2780 和 COR-L23 细胞，IC50 值分别为 0.7 nM 和 3.9 nM。

GC62470 AG-636 A DHODH inhibitor

GC62466 Ensifentrine

RPL-554

Ensifentrine (RPL-554) 是一种吸入式，首创的磷酸二酯酶 3 (PDE3) 和 PDE4 双重抑制剂，IC50 分别为 0.4 nM 和 1479 nM。Ensifentrine 具有支气管保护和抗炎活性，可用于慢性阻塞性肺疾病 (COPD) 的研究。

GC62439 Edoxaban impurity 6

依度沙班杂质F(单体)

Edoxaban impurity 6 是 Edoxaban 的一种杂质。Edoxaban (DU-176) 是一种选择性，有效和具有口服活性的 factor Xa (FXa) 抑制剂，对游离 FXa 和凝血酶原的 Ki 分别为 0.561 nM 和 2.98 nM。Edoxaban 是一种抗凝剂，可用于预防中风。