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Phenylacetyl-Coenzyme A (sodium salt)

(Synonyms: Phenylacetyl-CoA) 目录号 : GC48996

A key intermediate in aerobic catabolism of phenylacetate in bacteria

Phenylacetyl-Coenzyme A (sodium salt) Chemical Structure

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1 mg
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5 mg
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Phenylacetyl-coenzyme A (CoA) is a key intermediate in aerobic catabolism of phenylacetate in bacteria such as Pseudomonas, when cultured in minimal media using phenylacetate as the sole carbon source.1 It is a precursor in the synthesis of the antibiotic penicillin G found in industrial strains of P. chrysogenum. Phenylacetyl-CoA also acts as an effector molecule of the TetR family transcriptional repressor PaaR in T. thermophilus and the GntR family transcriptional regulator PaaX in E. coli and Pseudomonas, binding to each protein to induce derepression of various genes.2

1.MiÑambres, B., MartÍnex-Blanco, H., Olivera, E.R., et al.Molecular cloning and expression in different microbes of the DNA encoding Pseudomonas putida U phenylacetyl-CoA ligase. Use of this gene to improve the rate of benzylpenicillin biosynthesis in Penicillium chrysogenumJ. Biol. Chem.271(52)33531-33538(1996) 2.Sakamoto, K., Agari, Y., Kuramitsu, S., et al.Phenylacetyl coenzyme A is an effector molecule of the TetR family transcriptional repressor PaaR from Thermus thermophilus HB8J. Bacteriol.193(17)4388-4395(2011)

Chemical Properties

Cas No. N/A SDF
别名 Phenylacetyl-CoA
Canonical SMILES O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CC4=CC=CC=C4)=O)=O)=O)(O)=O)(O)=O)[C@H]1OP(O)(O)=O.[Na]
分子式 C29H42N7O17P3S·XNa 分子量 885.7
溶解度 PBS (pH 7.2): 10 mg/ml 储存条件 -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.1291 mL 5.6453 mL 11.2905 mL
5 mM 0.2258 mL 1.1291 mL 2.2581 mL
10 mM 0.1129 mL 0.5645 mL 1.1291 mL
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