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Dimethyl 2-ketoglutarate Sale

(Synonyms: alpha-酮戊二酸二甲酯) 目录号 : GC49016

An esterified form of α-ketoglutarate

Dimethyl 2-ketoglutarate Chemical Structure

Cas No.:13192-04-6

规格 价格 库存 购买数量
500 mg
¥378.00
现货
1 g
¥529.00
现货
5 g
¥1,331.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Dimethyl 2-ketoglutarate is an esterified form of the citric acid cycle intermediate α-ketoglutarate.1 It increases intracellular levels of α-ketoglutarate and decreases intracellular ATP levels in U2OS human osteosarcoma cells cultured in complete- or nutrient-free media when used at a concentration of 5 mM.2 Dimethyl 2-ketoglutarate inhibits autophagy and decreases in intracellular levels of acetyl-CoA in serum- and nutrient-deprived cells.3 It decreases cardiomyocyte hypertrophy in a mouse model of cardiac pressure overload induced by thoracic aortic constriction when administered at a dose of 300 mg/kg. Dimethyl 2-ketoglutarate reduces serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and hepatic fibrosis in a rat model of liver fibrosis induced by carbon tetrachloride (CCl4).1

1.Zhao, J., Peng, L., Cui, R., et al.Dimethyl α-ketoglutarate reduces CCl4-induced liver fibrosis through inhibition of autophagy in hepatic stellate cellsBiochem. Biophys. Res. Commun.481(1-2)90-96(2021) 2.Baracco, E.E., Castoldi, F., Durand, S., et al.α-Ketoglutarate inhibits autophagyAging (Albany NY)11(11)3418-3431(2021) 3.MariÑo, G., Pietrocola, F., Eisenberg, T., et al.Regulation of autophagy by cytosolic acetyl-coenzyme AMol. Cell53(5)710-725(2014)

Chemical Properties

Cas No. 13192-04-6 SDF
别名 alpha-酮戊二酸二甲酯
Canonical SMILES COC(CCC(C(OC)=O)=O)=O
分子式 C7H10O5 分子量 174.2
溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml 储存条件 -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 5.7405 mL 28.7026 mL 57.4053 mL
5 mM 1.1481 mL 5.7405 mL 11.4811 mL
10 mM 0.5741 mL 2.8703 mL 5.7405 mL
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