Metabolism(代谢)

Cat.No. 产品名称 Information

GC19892 Sodium chenodeoxycholate

鹅脱氧胆酸钠

A primary bile acid

GC63272 β-Apo-8’-carotenal

ψ-胡萝卜醛; Apocarotenal

Apocarotenal is a carotenoid found in spinach and citrus fruits and plays a role as a precursor of vitamin A.

GC63209 TAK-915 TAK-915 是一种有效的，选择性的，可透过血脑屏障和口服活性的 PDE2A 抑制剂，IC50 为 0.61 nM。TAK-915 对 PDE2A 的选择性是 PDE1A 的 4100 倍以上。TAK-915 可用于神经精神疾病和神经退行性疾病的研究。

GC63199 Soticlestat

TAK-935; OV935

A cholesterol 24-hydroxylase/CYP46A1 inhibitor

GC62977 FR-229934 FR-229934 是一种 PDE V 的抑制剂。FR-229934 可用于肺动脉高压和勃起功能障碍的研究。详细信息请参考专利文献 WO2019130052A1。

GC62974 FK614 FK614 是一种具有口服活性，有效的，选择性的 PPARγ 调制剂 (SPPARM)。FK614 对脂肪细胞分化各阶段 PPARγ 的激活有不同的影响。FK614 是一种非噻唑烷二酮类胰岛素增敏剂。FK614 可用于高血糖、高甘油三酯、葡萄糖耐受不良和 2 型糖尿病的研究。

GC62922 Darexaban

N-[2-羟基-6-(4-甲氧基苯甲酰氨基)苯基]-4-(4-甲基-1,4-二氮杂庚烷-1-基)苯甲酰胺,YM150

Darexaban (YM150) 是一种有效、选择性和具有口服活性的 Xa 因子 (FXa) 抑制剂，IC50 为 54.6 nM。Darexaban 对其他相关丝氨酸蛋白酶（如胰蛋白酶、凝血酶和激肽释放酶）显示出高选择性。Darexaban 具有抗凝和抗血栓形成作用。

GC62864 Benzolamide

CL11366

Benzolamide (CL11366) 是一种有效的碳酸酐酶 (CA) 抑制剂，抑制hCA I，hCA II，EcoCAγ 和 VchCAγ 的 Ki 值分别为15 nM，9 nM，94 nM 和 78 nM。Benzolamide 还抑制 CAS3，Ki 值为 54 nM。Benzolamide 可用于青光眼和癫痫的研究。

GC62846 AR453588 AR453588 是一种有效的口服生物利用的抗糖尿病葡萄糖激酶 (glucokinase) 激活剂，EC50为 42 nM。AR453588 具有降血糖作用。

GC62836 AMG131

2,4-二氯-N-[3,5-二氯-4-(喹啉-3-基氧基)苯基]苯磺酰胺,INT131

AMG131 (INT131) 是一种有效且高度选择性的 PPARγ 部分激动剂，可与 PPARγ 结合，取代罗格列酮，Ki 为~10 nM。 AMG131 可用于研究 2 型糖尿病 (T2DM)。

GC62777 2-Methoxy-4-vinylphenol

4-乙烯基-2-甲氧基苯酚

2-Methoxy-4-vinylphenol (2M4VP) 是天然的发芽抑制剂，具有抗炎活性。

GC62743 (Rac)-EC5026

(Rac)-BPN-19186

(Rac)-EC5026 ((Rac)-BPN-19186) 是一种有效的可溶性环氧水解酶 (sEH) 抑制剂，Ki 值为 0.06 nM。详细信息请参考专利文献 WO2019156991A1 中的第 39 页。(Rac)-EC5026 可用于帕金森氏病和路易体痴呆 (DLB) 的研究。

GC19852 4-Methylumbelliferyl-α-D-glucopyranoside

7-(α-D-吡喃葡糖氧基)-4-甲基-2H-1-苯并吡喃-2-酮

A fluorogenic substrate for α-glucosidase

GC49439 (±)11(12)-DiHET MaxSpec® Standard

(±)11,12-DiHETrE

A quantitative analytical standard guaranteed to meet MaxSpec^® identity, purity, stability, and concentration specifications

GC49435 rac-1,2-bis-Palmitoyl-3-chloropropanediol

RAC-1,2-双(十五烷酸)-3-氯乙二醇酯

A 3-MCPD ester

GC49434 Tauroursodeoxycholic Acid (sodium salt hydrate)

3α,7β-dihydroxy-5β-cholanoyl Taurine, Sodium Tauroursodeoxycholate, TUDCA, UR-906

A taurine-conjugated form of ursodeoxycholic acid

GC49429 6-keto Lithocholic Acid

3Α-羟基-6K-5Β-胆甾烷-24-酸

A metabolite of lithocholic acid

GC49428 O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine A major metabolite of amlodipine

GC49427 3,5-Diiodo-L-thyronine

3,5-二碘-L-甲状腺素,3,5-Diiodo-L-thyronine

A thyroid hormone metabolite

GC49421 Atorvastatin lactone-d5 An internal standard for the quantification of atorvastatin lactone

GC49419 Aniline-d5

苯胺-2,3,4,5,6-d5

An internal standard for the quantification of aniline

GC49418 Glycine-13C

甘氨酸 2-13C

An internal standard for the quantification of glycine

GC49416 Gap 27 (trifluoroacetate salt)

43Gap27, SRPTEKTIFII

A connexin-mimetic peptide

GC49414 p-Cresol Glucuronide

4-Cresol Glucuronide, p-Tolyl-β-D-glucuronide

A metabolite of p-cresol

GC49410 CVT-2738

N-(2,6-二甲基苯基)-1-哌嗪乙酰胺

An active metabolite of ranolazine

GC49409 Desmethyl Ranolazine

雷诺嗪杂质

A metabolite of ranolazine

GC49406 ACT-373898 A metabolite of macitentan

GC49403 Benzarone

苯扎隆,Fragivix

An active metabolite of benzbromarone

GC49401 Triptolide-d3

PG490-d3

Triptolide-d3 (PG490-d3) 是氘标记的雷公藤内酯。雷公藤内酯是从雷公藤根中提取的二萜类三环氧化物，具有免疫抑制、抗炎、抗增殖和抗肿瘤作用。雷公藤内酯是一种 NF-κB 活化抑制剂。

GC49399 N-Desbutyl Dronedarone (hydrochloride)

N-[2-丁基-3-[4-[3-(丁基氨基)丙氧基]苯甲酰基]-5-苯并呋喃基]甲磺酰胺盐酸盐,SR35021 hydrochloride

An active metabolite of dronedarone

GC49393 all-trans-13,14-Dihydroretinol A metabolite of all-trans retinoic acid

GC49391 7α-Thiospironolactone

Deacetylspironolactone, Mercaptospironolactone, SC-24813, 7α-Thio-SL

An active metabolite of spironolactone

GC49389 Tritylolmesartan Medoxomil

三苯甲基奥美沙坦酯

An intermediate in the synthesis of olmesartan medoxomil

GC49388 N-Butyldeoxynojirimycin-d9 (hydrochloride)

[2H9]-N-丁基脱氧野尻霉素盐酸盐,N-Butyldeoxynojirimycin-d9 hydrochloride; NB-DNJ-d9 hydrochloride; OGT 918-d9 hydrochloride

An internal standard for the quantification of N-butyldeoxynojirimycin

GC49387 Berberine-d6 (chloride)

Natural Yellow 18-d6 chloride

An internal standard for the quantification of berberine

GC49382 L-Lysine-d3 (hydrochloride)

L-赖氨酸 d3 (盐酸)

An internal standard for the quantification of L-lysine

GC49381 L-Leucine-d10

L-亮氨酸 d10

An internal standard for the quantification of L-leucine

GC49375 L-Asparagine-d3 (hydrate)

L-(+)-无水天冬酰胺酸 d3 (hydrate)

An internal standard for the quantification of L-asparagine

GC49373 L-Alanine-d3

L-丙氨酸-3,3,3-D3,L-2-Aminopropionic acid-d3

An internal standard for the quantification of L-alanine

GC49371 L-Valine-d8

L-缬氨酸-D8; L-VALINE-2,3,4,4,4,5,5,5-d8

An internal standard for the quantification of L-valine

GC49370 L-Tryptophan-d5

L-色氨酸-D5,Tryptophan-d5; Tryptophane-d5

L-色氨酸-d5（L-Tryptophan-d5）是L-色氨酸的氘代化合物，用作GC或LC-MS定量中的标准品。

GC49369 L-Threonine-d2

L-苏氨酸 d2

An internal standard for the quantification of L-threonine

GC49367 4’-hydroxy Atomoxetine Glucuronide (hydrate) A metabolite of atomoxetine

GC49366 1-Salicylate Glucuronide

Salicyl Phenolic Glucuronide, Salicylic Acid Phenolic Glucuronide

A metabolite of salicylic acid and aspirin

GC49365 25-Desacetyl Rifampicin

25-乙酰-3-[(五)-[(4-甲基-1-哌嗪基)亚胺]甲基]利福霉素

A major active metabolite of rifampicin

GC49363 Salicyluric Acid

2-羟基马尿酸

A major metabolite of aspirin and salicylic acid

GC49362 2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline

2-氨基-3,8-二甲基咪唑并喹喔啉

A food-derived carcinogen

GC49359 IM-156 (acetate)

HL156A, HL271

A mitochondrial complex I inhibitor and an AMPKα activator

GC49355 Norfluoxetine-d5 (hydrochloride)

诺氟西汀-D5

An internal standard for the quantification of norfluoxetine

GC49349 O-Desethyl Sildenafil

西地那非杂质C

A metabolite of sildenafil