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Desmethyl Ranolazine Sale

(Synonyms: 雷诺嗪杂质) 目录号 : GC49409

A metabolite of ranolazine

Desmethyl Ranolazine Chemical Structure

Cas No.:172430-45-4

规格 价格 库存 购买数量
500 µg
¥1,525.00
现货
1 mg
¥2,895.00
现货
5 mg
¥11,443.00
现货
10 mg
¥16,770.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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产品描述

Desmethyl ranolazine is a metabolite of the antianginal agent ranolazine .1 It is formed from ranolazine by the cytochrome P450 (CYP) isoform CYP3A.

1.Wang, Y., Chen, X., Sun, Z., et al.Development and validation of a sensitive LC-MS/MS assay for simultaneous quantitation of ranolazine and its three metabolites in human plasmaJ. Chromatogr. B889-89010-16(2012)

Chemical Properties

Cas No. 172430-45-4 SDF
别名 雷诺嗪杂质
Canonical SMILES O=C(CN1CCN(CC(COC2=C(O)C=CC=C2)O)CC1)NC3=C(C)C=CC=C3C
分子式 C23H31N3O4 分子量 413.5
溶解度 DMSO: soluble 储存条件 -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.4184 mL 12.0919 mL 24.1838 mL
5 mM 0.4837 mL 2.4184 mL 4.8368 mL
10 mM 0.2418 mL 1.2092 mL 2.4184 mL
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Research Update

Enantioselective analysis of ranolazine and Desmethyl Ranolazine in microsomal medium using dispersive liquid-liquid microextraction and LC-MS/MS

Bioanalysis 2013 Jan;5(2):171-83.PMID:23330560DOI:10.4155/bio.12.308.

Background: An enantioselective bioanalytical method using dispersive liquid-liquid microextraction (DLLME) and LC-MS/MS was developed for the chiral analysis of ranolazine (RNZ) and one of its metabolites (Desmethyl Ranolazine [DRNZ]). Results: The analytes were extracted from microsomal medium by DLLME, using chloroform as extractor solvent and acetone as dispersive solvent. The enantiomers of RNZ and DRNZ were analyzed simultaneously for the first time using a Chiralcel OD-H(?). Method validation showed recoveries in the order of 55 and 45%, and LLOQ of 25 and 10 ng ml(-1) for the enantiomers of RNZ and DRNZ, respectively. Linearity was established in the concentration range of 10 to 1000 and 25 to 2500 ng ml(-1) for each DRNZ and RNZ enantiomer, respectively. Conclusion: The unprecedented use of DLLME was demonstrated to be very useful for sample preparation of microsomal matrix. Furthermore, the in vitro metabolism of RNZ was enantioselective.