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Gap 27 (trifluoroacetate salt) Sale

(Synonyms: 43Gap27, SRPTEKTIFII) 目录号 : GC49416

A connexin-mimetic peptide

Gap 27 (trifluoroacetate salt) Chemical Structure

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500 µg
¥942.00
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1 mg
¥1,508.00
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5 mg
¥6,595.00
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10 mg
¥11,306.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Gap 27 is a connexin-mimetic peptide that corresponds to amino acids 204-214 of extracellular loop 2 in connexin 43.1 It reduces survival of isolated rat osteoclasts when used at a concentration of 500 µM and decreases bone resorption in rat bone slice and osteoclast co-cultures.2 Gap 27 accelerates wound closure and stratification of the corneal epithelium in isolated human corneas.3 In vivo, Gap 27 reduces cardiac remodeling and the incidence of cardiac arrhythmias in a rat model of arterio-venous fistula (AV-shunt) surgery-induced high-output heart failure.4

1.Wright, C.S., Pollok, S., Flint, D.J., et al.The connexin mimetic peptide Gap27 increases human dermal fibroblast migration in hyperglycemic and hyperinsulinemic conditions in vitroJ. Cell. Physiol.227(1)77-87(2012) 2.Ilvesaro, J., Tavi, P., and Tuukkanen, J.Connexin-mimetic peptide Gap 27 decreases osteoclastic activityBMC Musculoskelet. Disord.210(2001) 3.Elbadawy, H.M., Mirabelli, P., Xeroudaki, M., et al.Effect of connexin 43 inhibition by the mimetic peptide Gap27 on corneal wound healing, inflammation and neovascularizationBr. J. Pharmacol.173(19)2880-2893(2016) 4.Lucero, C.M., Andrade, D.C., Toledo, C., et al.Cardiac remodeling and arrhythmogenesis are ameliorated by administration of Cx43 mimetic peptide Gap27 in heart failure ratsSci. Rep.10(1)6878(2020)

Chemical Properties

Cas No. N/A SDF
别名 43Gap27, SRPTEKTIFII
Canonical SMILES OC[C@H](N)C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)[C@@H](C)CC)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
分子式 C60H101N15O17·XCF3COOH 分子量 1304.6
溶解度 DMSO: slightly soluble,Ethanol: slightly soluble,Methanol: slightly soluble 储存条件 -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.7665 mL 3.8326 mL 7.6652 mL
5 mM 0.1533 mL 0.7665 mL 1.533 mL
10 mM 0.0767 mL 0.3833 mL 0.7665 mL
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