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Home >> Signaling Pathways >> Metabolism

Metabolism(代谢)

  1. Cat.No. 产品名称 Information
  2. GC46387 1,3,7-Trimethyluric Acid-d9

    TMU-d9, 8-oxo Caffeine-d9

     An internal standard for the quantification of 1,3,7-trimethyluric acid
  3. GC46373 1,2,3-Triundecanoyl Glycerol

    11碳酸三甘油酯

     A triacylglycerol
  4. GC46365 1,1'-(Azodicarbonyl)dipiperidine

    偶氮二甲酰二哌啶

     A Mitsunobu reagent
  5. GC46352 (S)-DO271 An inactive control for DO264
  6. GC46350 (S)-Bromoenol lactone-d7

    (S)-BEL-d7; (S,E)-Bromoenol lactone-d7

     A neuropeptide with diverse biological activities
  7. GC46347 (S)-(+)-Methoprene

    S-(+)-烯虫酯,(+)-Methoprene; (7S)-Methoprene

     An insect growth regulator and Met agonist
  8. GC46342 (R)-Bromoenol lactone-d7

    (R)BELd7

     A neuropeptide with diverse biological activities
  9. GC46333 (4′-Hydroxy)phenoxybenzoic Acid

    3-(4'-羟基)苯氧基苯甲酸

     A pyrethroid insecticide metabolite
  10. GC46332 (2S)-Octyl-α-hydroxyglutarate-d17

    (2S)-Octyl-2-HG-d17

     A neuropeptide with diverse biological activities
  11. GC46330 (2R)-Octyl-α-hydroxyglutarate-d17

    (2R)Octyl2-HG-d17

     A neuropeptide with diverse biological activities
  12. GC46314 (±)-β-Hydroxybutyrate-d4 (sodium salt)

    β-Hydroxybutyric acid-d4 sodium

     An internal standard for the quantification of (±)-β-hydroxybutyrate
  13. GC46284 (±)-Cotinine-d3

    氘代甲基可替宁,(±)-Cotinine-d3; (Rac)-NIH-10498-d3

     An internal standard for the quantification of cotinine
  14. GC46268 (±)9-HETE-d8

    (±)9-Hydroxyeicosatetraenoic Acid-d8

     A neuropeptide with diverse biological activities
  15. GC46264 (±)8(9)-EET-d11

    (±)8,9-EET-d11, (±)8,9-EpETrE-d11

     A neuropeptide with diverse biological activities
  16. GC46262 (±)5(6)-EET-d11

    (±)5,6-EET-d11

     A neuropeptide with diverse biological activities
  17. GC46260 (±)17(18)-EpETE

    (±)17,18-EEQ, (±)17,18-epoxy Eicosatetraenoic Acid

     A neuropeptide with diverse biological activities
  18. GC46257 (±)12(13)-EpOME-d4

    (±)12,13-EODE-d4, Isoleukotoxin-d4, (±)Vernolic Acidd4

     A neuropeptide with diverse biological activities
  19. GC46256 (±)12(13)-DiHOME-d4

    Isoleukotoxin diold4

     A neuropeptide with diverse biological activities
  20. GC61355 Tris(2,4-di-tert-butylphenyl)phosphate

    三(2,4-二-叔丁基苯基)磷酸酯

     Tris(2,4-di-tert-butylphenyl)phosphate是从VitexnegundoL.中分离的一种活性化合物，具有抗炎活性，并通过分子对接抑制了分泌性磷脂酶A2(sPLA2)。
  21. GC61344 trans-Benzylideneacetone

    亚苄基丙酮; trans-Benzalacetone

     Trans-4-Phenyl-3-buten-2-one (trans-Benzylideneacetone, trans-Benzalacetone, trans-Benzylideneacetone) is an inhibitor of the enzyme phospholipase A2 (PLA2). Trans-4-Phenyl-3-buten-2-one is used as a flavouring agent, a fragrance and a bacterial metabolite.
  22. GC61251 Rosuvastatin D3

    ZD 4522 D3

     RosuvastatinD3(ZD4522D3)是Rosuvastatin的一种氘代化合物。Rosuvastatin(ZD4522)是一种竞争性HMG-CoA还原酶抑制剂，IC50为11nM。Rosuvastatin有效阻断人类醚-a-go-go相关基因(hERG)电流，IC50为195nM，延迟心脏复极化，从而延长动作电位持续时间(APDs)和校正QT间期(QTc)间隔。
  23. GC61191 Piperonylic acid

    胡椒酸

     Piperonylicacid是具有亚甲二氧基功能的天然分子，模拟反式肉桂酸的结构。Piperonylicacid是反式肉桂酸4-羟化酶的选择性的灭活剂。
  24. GC61187 Pioglitazone D4

    匹格列酮-D4,U 72107-d4

     An internal standard for the quantification of pioglitazone
  25. GC61155 Omeprazole sodium

    奥美拉唑钠,H 16868 sodium

     An irreversible inhibitor of the gastric proton pump
  26. GC61055 Methyl oleanonate

    3-Oxoolean-12-en-28-oic acid methyl ester

     Methyloleanonate是从Pistacia中分离得到的三萜类PPARγ激动剂。Methyloleanonate是齐墩果酸衍生物，具有抗癌作用。
  27. GC61043 Mesalamine impurity P

    美沙拉嗪EP杂质P

     MesalamineimpurityP是Mesalamine的杂质。5-Aminosalicylicacid(Mesalamine)是一种特异性的 PPARγ 激动剂，还抑制p21-激活激酶1(PAK1)和 NF-κB。
  28. GC61040 Melittin TFA

    蜂毒肽三氟乙酸盐；蜂毒素三氟乙酸盐

     Melittin (MLT, Forapin, Forapine) is an activator of phospholipase A2 (PLA2) that stimulates the activity of the low molecular weight PLA2, while it does not the increase the activity of the high molecular weight enzyme.
  29. GC60982 LEI-401 An NAPE-PLD inhibitor
  30. GC60970 KY19382

    A3051

     KY19382 (A3051) is a Wnt/β-catenin signalling activator through inhibitory effects on both CXXC5–DVL interaction and GSK3β activity with IC50s of 19 nM and 10 nM, respectively.
  31. GC60899 Hibifolin

    棉花皮素-8-O-葡萄糖醛酸苷

     Hibifolin (Gossypetin-8-O-β-D-glucuronide) is a flavonol glycoside and acts as a potential inhibitor of adenosine deaminase (ADA) with a Ki of 49.92 μM. Hibifolin prevents β-amyloid-induced neurotoxicity in cultured cortical neurons.
  32. GC60886 GSK356278 A selective PDE4 inhbitor
  33. GC60833 FB23 FB23 is a potent and selective inhibitor of FTO demethylase with IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity.
  34. GC60832 FASN-IN-4 tosylate FASN-IN-4tosylate是高效的脂肪酸合酶FASN抑制剂，来自专利WO2012064642A1化合物实例29，IC50值为10nM。
  35. GC60791 Doxepin D3 Hydrochloride

    盐酸多塞平 D3

     DoxepinD3Hydrochloride是DoxepinHydrochloride的氘代物。Doxepinhydrochloride是一种口服活性的三环抗抑郁药。Doxepinhydrochloride是一种有效的选择性组胺受体H1拮抗剂。Doxepinhydrochloride也是一种有效的CYP450抑制剂，并显着抑制CYP4502C19和CYP4501A2。
  36. GC60763 DHODH-IN-11

    Dihydroorotate Dehydrogenase Inhibitor 11

     A derivative of leflunomide
  37. GC60710 Ciprofibrate impurity A

    环丙贝特杂质A

     CiprofibrateimpurityA是Ciprofibrate的一种杂质。Ciprofibrate是一种PPARα激动剂。
  38. GC60675 Caulophyllogenin

    儿茶酚

     Caulophyllogenin是一种从M.polimorpha中提取的三萜皂苷。Caulophyllogenin是PPARγ的部分激动剂，EC50值为12.6μM。Caulophyllogenin可用于研究2型糖尿病，肥胖症，代谢综合征和炎症。
  39. GC60519 4-Hydroxyderricin

    4-羟基德里辛

     4-Hydroxyderricin(4-HD), the major active ingredients of Angelica keiskei Koidzumi, is a potent selective monoamine oxidase (MAO) inhibitor with mild inhibitory effect on dopamine β-hydroxylase.
  40. GC60517 4-Hydroxyatomoxetine

    4'-羟基托莫西汀

     A metabolite of atomoxetine
  41. GC60446 1-Ethynylpyrene

    1-乙炔基芘

     1-Ethynylpyrene是细胞色素P4501A1,1A2和2B1的抑制剂，IC50分别为0.18，0.32和0.04μM。
  42. GC60396 (3S,5R)-Fluvastatin sodium

    (3S,5R)氟伐他汀钠盐,(3S,5R)-XU 62-320

     (3S,5R)-Fluvastatinsodium((3S,5R)-XU62-320)是Fluvastatin的(3S,5R)对映体。Fluvastatin是第一个完全合成的，竞争性的HMG-CoAreductase还原酶抑制剂，IC50为8nM。Fluvastatin通过依赖Nrf2的抗氧化通路保护血管平滑肌细胞免受氧化应激。
  43. GC46243 24-dehydro Cholesterol-d6

    Desmosterol-d6

     An internal standard for the quantification of 24-dehydro cholesterol
  44. GC46242 7-dehydro Cholesterol-d7

    7-去氢胆固醇 d7

     An internal standard for the quantification of 7-dehydro cholesterol
  45. GC46241 7-keto Cholesterol-d7

    7-酮基胆固醇-D7,7-oxo Cholesterol-d7

     An internal standard for the quantification of 7-keto cholesterol
  46. GC60329 Robustine

    大叶桉亭

     Robustine，是一种来自 Dictamnus albus 的呋喃喹啉生物碱，在体外对人磷酸二酯酶 5 (hPDE5A) 具有抑制作用。
  47. GC60326 Rivaroxaban D4

    5-氯-N-[[(5S)-2-氧代-3-[4-(3-氧代-4-吗啉基)苯基-2,3,5,6-D4]-5-恶唑烷基]甲基]-2-噻吩甲酰胺,BAY 59-7939-d4

     An internal standard for the quantification of rivaroxaban
  48. GC60278 OT-82 OT-82 is a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with average IC50s of 13.03 ??nM in non-HP cancer cells and 2.89? ?nM in HP cancer cells, respectively.
  49. GC60249 Mizagliflozin

    DSP-3235 free base; KGA-3235 free base; GSK-1614235 free base

     Mizagliflozin是一种新型的SGLT1抑制剂，抑制常数Ki为27.0±1.5nM，可用于治疗糖尿病，改善餐后血糖波动。
  50. GC60212 K777

    APC-3316, CRA-3316, K11777, MePip-Phe-hPhe-VSφ

     A cysteine protease inhibitor
  51. GC60202 Inz-1 Inz-1是一种有效的、选择性的酵母线粒体细胞色素bc1(mitochondrialcytochromebc1)抑制剂(IC50=8.092μM)，优于对人的(IC50=45.320μM)。Inz-1逆转白色念珠菌对氟康唑或其他三唑抗真菌试剂的耐药性。

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