Metabolism(代谢)

Cat.No. 产品名称 Information

GC46215 S-Acetyl-L-glutathione

S-乙酰-L-谷胱甘肽

A derivative of glutathione

GC46213 Ro 41-0960 A COMT inhibitor

GC46208 Propentofylline

普罗潘非林,HWA 285

A xanthine derivative and neuroprotective agent

GC46192 Octanoic Acid-13C

辛酸-1-13C,Caprylic acid-13C

An internal standard for the quantification of octanoic acid

GC46187 Norhyodeoxycholic Acid

去甲去氧胆酸

A synthetic bile acid

GC46175 MOTS-c (human) (trifluoroacetate salt)

Mitochondrial open reading frame of the 12S rRNA-c

具有多种生物活性的神经肽

GC46168 MBX-8025 (sodium salt) A PPARδ agonist

GC46138 ENPP1 Inhibitor C An ENPP1 inhibitor

GC46131 Diazoxide-d3

二氮嗪D3,Sch-6783-d3; SRG-95213-d3

An internal standard for the quantification of diazoxide

GC46119 Cholic Acid anilide A synthetic bile acid

GC46118 Chlothianidin

噻虫胺

A neonicotinoid insecticide

GC46114 CAY10761 An ENPP1 inhibitor

GC46105 Butyrolactone II A fungal metabolite

GC46104 Butyric Acid-d7

氘代丁酸(D7),Butanoic acid-d7

An internal standard for the quantification of sodium butyrate

GC46101 Brinzolamide-d5

布林佐胺杂质,AL-4862-d5

An internal standard for the quantification of brinzolamide

GC46085 Alphitonin A flavonoid

GC46083 Adenylosuccinic Acid

腺苷酸基琥珀酸,Aspartyl Adenylate

腺苷琥珀酸是一种嘌呤核苷酸，也是嘌呤核苷酸循环中的中间产物

GC46080 7,3',4'-Trihydroxyflavone

3',4',7-三羟基黄酮

A flavonoid with diverse biological activities

GC46069 4-Amino-5-(bromomethyl)-2-methylpyrimidine (hydrobromide) A heterocyclic building block

GC46068 3β-OH-7-Oxocholenic Acid

3β-hydroxy-7-oxo-5-Cholenoic Acid, 3β-hydroxy-7-Oxochol-5-enoic Acid

A bile acid

GC46040 1,2,3-Trielaidoyl-rac-glycerol

三反油酸甘油酯9C18:1反

A triacylglycerol

GC39191 iRucaparib-AP6 iRucaparib-AP6 是高效且特异的 PARP1 降解剂，基于 Rucaparib (PROTAC 的方法)。 iRucaparib-AP6 是一种 "非捕获性" PARP1 降解剂，可同时阻断 PARP1 的催化活性和支架作用。

GC39178 Canagliflozin D4

卡格列净D4,JNJ 28431754-d4

An internal standard for the quantification of canagliflozin

GC39168 GSK2945 hydrochloride GSK2945 hydrochloride 是一类叔胺，是一种高度特异性的 Rev-erbα/REV-ERBα (小鼠/人反向成红细胞病病毒α) 拮抗剂，其 EC50 值分别为 21.5 μM 和 20.8 μM。GSK2945 hydrochloride 可增强胆固醇 7α-羟化酶 (CYP7A1) 水平和胆固醇代谢。

GC39160 BCI-215 BCI-215 是一种高效、肿瘤细胞选择性的双重特异性磷酸酶 DUSP-MKP 抑制剂。BCI-215 对肿瘤细胞有细胞毒性，但对正常细胞无毒性。

GC39127 Palmatine

黄藤素

An alkaloid with diverse biological activities

GC38967 Lycorine

石蒜碱

An alkaloid with diverse biological activities

GC38921 Lirimilast

BAY 19-8004

Lirimilast (BAY 19-8004) 是一种有效的，选择性的和口服活性的磷酸二酯酶 4 (PDE4) 抑制剂，IC50 值为 49 nM。Lirimilast 可用于治疗哮喘或慢性阻塞性肺疾病 (COPD)，具有强效的抗炎特性。

GC38919 KY-226

抑制剂

KY-226 is a potent, selective, orally active and allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 μM for human PTP1B activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively.

GC38916 GNF362 GNF362 是肌醇三磷酸3'激酶 B (Itpkb) 的选择性，有效且可口服生物利用的抑制剂，IC50为 9 nM。 GNF362 还抑制 Itpka 和 Itpkc，IC50 值分别为 20 nM 和 19 nM。肌醇三磷酸3'激酶 B (Itpkb) 是一种 Ca2+ 依赖性激酶，其磷酸化 Ins (1,4,5) P3 的 3' 位置，生成肌醇 1,3,4,5-四磷酸 [Ins (1,3,4,5) P4]。