7,3',4'-Trihydroxyflavone
(Synonyms: 3',4',7-三羟基黄酮) 目录号 : GC46080
A flavonoid with diverse biological activities
Cas No.:2150-11-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
7,3',4'-Trihydroxyflavone is a flavonoid that has been found in A. julibrissin bark and has diverse biological activities.1,2,3,4 It scavenges 2,2-diphenyl-1-picrylhydrazyl and peroxynitrite radicals in cell-free assays (IC50s = 2.2 and 5.78 μM, respectively), as well as reduces total reactive oxygen species in rat kidney homogenates (IC50 = 3.9 μM).1 7,3',4'-Trihydroxyflavone inhibits COX-1 (IC50 = 36.7 μM).2 It is active against M. tuberculosis (MIC = 50 μg/ml).3 It decreases mRNA expression of the osteoclastic marker genes encoding the calcitonin receptor, cathepsin K1 V-ATPase V0 subunit d2 (Atp6v0d2), and dendritic cell specific transmembrane protein (Dcstamp) in and inhibits RANKL-induced osteoclastic differentiation of mouse bone marrow-derived macrophages (BMDMs).4
|1. Jung, M.J., Chung, H.Y., Kang, S.S., et al. Antioxidant activity from the stem bark of Albizzia julibrissin. Arch. Pharm. Res. 26(6), 458-462 (2003).|2. Selvam, C., Jachak, S.M., and Bhutani, K.K. Cyclooxygenase inhibitory flavonoids from the stem bark of Semecarpus anacardium Linn. Phytother. Res. 18(7), 582-584 (2004).|3. Chokchaisiri, R., Suaisom, C., Sriphota, S., et al. Bioactive flavonoids of the flowers of Butea monosperma. Chem. Pharm. Bull. (Tokyo) 57(4), 428-432 (2009).|4. Kang, J.H., Lee, J., Moon, M., et al. 3'4'7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. Pharmazie 70(10), 661-667 (2015).
| Cas No. | 2150-11-0 | SDF | |
| 别名 | 3',4',7-三羟基黄酮 | ||
| Canonical SMILES | O=C1C=C(C2=CC=C(O)C(O)=C2)OC3=C1C=CC(O)=C3 | ||
| 分子式 | C15H10O5 | 分子量 | 270.2 |
| 溶解度 | DMF: 5 mg/ml,DMSO: 5 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.701 mL | 18.5048 mL | 37.0096 mL |
| 5 mM | 0.7402 mL | 3.701 mL | 7.4019 mL |
| 10 mM | 0.3701 mL | 1.8505 mL | 3.701 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。