Home>>(±)17(18)-EpETE

(±)17(18)-EpETE Sale

(Synonyms: (±)17,18-EEQ, (±)17,18-epoxy Eicosatetraenoic Acid) 目录号 : GC46260

A neuropeptide with diverse biological activities

(±)17(18)-EpETE Chemical Structure

规格 价格 库存 购买数量
25 μg
¥770.00
现货
50 μg
¥1,388.00
现货
100 μg
¥2,467.00
现货
500 μg
¥11,564.00
现货

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

View current batch:

产品描述

The epoxygenase pathway is one of the three major branches of eicosanoid biosynthesis.1,2 However, the cytochrome P450 metabolites of eicosapentaenoic acid and docosahexaenoic acid have been little studied relative to arachidonate epoxygenase metabolites. (±)17(18)-EpETE is biosynthesized by the stereospecific epoxidation of the ω-3 bond of EPA. (±)17(18)-EpETE at 100 nM was found to be a potent and selective activator of BK-type calcium activated potassium ion channels in vascular smooth muscle cells.3 It is possible that some of the physiologic effects of fish oil-enhanced diets could be due to this epoxygenase metabolite.

1.Fitzpatrick, F.A., and Murphy, R.C.Cytochrome P-450 metabolism of arachidonic acid: Formation and biological actions of 'epoxygenase'-derived eicosanoidsPharmacol. Rev.40(4)229-241(1989) 2.Oliw, E.H., Bylund, J., and Herman, C.Bisallylic hydroxylation and epoxidation of polyunsaturated fatty acids by cytochrome P450Lipids31(10)1003-1021(1996) 3.Lauterbach, B., Barbosa-Sicard, E., Wang, M.H., et al.Cytochrome P450-dependent eicosapentaenoic acid metabolites are novel BK channel activatorsHypertension39(2 Pt. 2)609-613(2002)

Chemical Properties

Cas No. N/A SDF
别名 (±)17,18-EEQ, (±)17,18-epoxy Eicosatetraenoic Acid
Canonical SMILES CC[C@@H]1[C@@H](O1)C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O
分子式 C20H30O3 分子量 318.5
溶解度 DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 3.1397 mL 15.6986 mL 31.3972 mL
5 mM 0.6279 mL 3.1397 mL 6.2794 mL
10 mM 0.314 mL 1.5699 mL 3.1397 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置