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Home >> Signaling Pathways >> Metabolism

Metabolism(代谢)

  1. Cat.No. 产品名称 Information
  2. GC11610 Pemetrexed

    培美曲塞二钠盐; LY231514 disodium

     An antifolate with anticancer activity
  3. GC16892 XL-888

    Xl 888, Xl888

     An orally bioavailable Hsp90 inhibitor
  4. GC16966 VER 155008

    adenosine-derived inhibitor, VER155008, VER-155008

     An Hsp70 inhibitor
  5. GC13885 Elesclomol (STA-4783)

    伊利司莫; STA-4783

     Elesclomol（也称为 STA-4783）最初是在基于细胞的表型筛选中发现的促凋亡活性，是一种新型小分子，可通过快速产生活性氧 (ROS) 有效诱导癌细胞凋亡以及难以控制的氧化应激水平的诱导。
  6. GC17655 Ganetespib (STA-9090)

    STA9090, STA 9090

     Ganetespib (STA-9090) (STA-9090) 是一种热休克蛋白 90 (HSP90) 抑制剂，在多种血液和实体肿瘤细胞系中表现出强效细胞毒性。 Ganetespib (STA-9090) 通过抑制 HIF-1α 在结直肠癌中具有抗血管生成作用；和 STAT3。
  7. GC15274 PF-04620110

    PF 04620110,PF04620110

     A potent, bioavailable inhibitor of DGAT-1
  8. GC17921 Tolcapone

    托卡朋; Ro 40-7592

     A reversible COMT inhibitor
  9. GC15614 A922500

    DGAT-1抑制剂,A-922500, A 922500

     A diacylglycerol acyltransferase 1 inhibitor
  10. GC14308 FK866 (APO866)

    达珀利奈; FK866; APO866

    Inhibitor of nicotinamide phosphoribosyltransferase
  11. GC10330 Lonafarnib

    洛那法尼,Sch 66336, Sch66336, Sch-66336

     A farnesyltransferase inhibitor with antitumor activity
  12. GC15848 Torcetrapib

    托彻普; CP-529414

     A CETP inhibitor
  13. GC14061 Evacetrapib (LY2484595)

    反式-4-[[(5S)-5-[[[3,5-双(三氟甲基)苯基]甲基](2-甲基-2H-四氮唑-5-基)氨基]-2,3,4,5-四氢-7,9-二甲基-1H-1-苯并氮杂卓-1-基]甲基]环己烷羧酸,LY2484595

     A CETP inhibitor
  14. GC13856 Dalcetrapib (JTT-705, RO4607381)

    达塞曲匹; JTT-705; RO4607381

     An inhibitor of cholesteryl ester transfer protein
  15. GC17520 Anacetrapib (MK-0859)

    安塞曲匹; MK-0859

     A CETP inhibitor
  16. GC16984 PF-3845 Inhibitor of FAAH
  17. GC13912 NLG919

    1-环己基-2-(5H-咪唑并[5,1-A]异吲哚-5-基)乙醇,NLG-919 analogue; GDC-0919 analogue

     An IDO pathway inhibitor
  18. GC15951 URB597

    FAAH Inhibitor II, URB-597, URB 597, KDS-4103

     An inhibitor of FAAH
  19. GC10380 Ferrostatin-1 (Fer-1)

    Fer-1

     Ferrostatin-1是一种有效的铁死亡抑制剂，EC50为60纳摩尔。
  20. GC11703 Moclobemide (Ro 111163)

    吗氯贝胺; Ro111163

     An Analytical Reference Standard
  21. GC14538 Pravastatin sodium

    普伐他汀钠; CS-514 sodium

     Pravastatin sodium 是一种HMG-CoA可逆的竞争性抑制剂，IC50为5.6μM，通常用于高胆固醇血症和冠心病的研究。
  22. GC14673 Safinamide Mesylate

    沙芬酰胺甲磺酸盐,FCE-28073, PNU 151774E, methanesulfonate

     An inhibitor of MAO-B
  23. GC14038 Atorvastatin Calcium

    阿托伐他汀钙; CI-981; Atorvastatin hemicalcium

     An HMG-CoA reductase inhibitor
  24. GC12801 Rasagiline Mesylate

    甲磺酸雷沙吉兰; (R)-AGN1135 mesylate; TVP1012 mesylate

     An inhibitor of MAO-B
  25. GC11633 Lovastatin

    洛伐他汀; Mevinolin

    Lovastatin是一种3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂，通过影响甲羟戊酸途径来发挥作用，IC50值为77nM。
  26. GC14226 Methazolamide

    醋甲唑胺; L584601

     A carbonic anhydrase inhibitor
  27. GC15541 Fluvastatin Sodium

    氟伐他汀钠,XU 62-320

     An HMG-CoA reductase inhibitor
  28. GC15158 Tioxolone

    噻克索酮

     A carbonic anhydrase I inhibitor
  29. GC14581 JNJ-1661010

    JNJ 1661010,JNJ1661010

     A selective FAAH inhibitor
  30. GC16149 Topiramate

    托吡酯; McN 4853; RWJ 17021

     An anticonvulsant
  31. GC10737 Brinzolamide

    布林佐胺; AL-4862

     A potent carbonic anhydrase inhibitor
  32. GC17378 U-104

    SLC-0111

     A carbonic anhydrase inhibitor
  33. GC17748 Dorzolamide HCl

    盐酸多佐胺; L671152 hydrochloride; MK507 hydrochloride

     A carbonic anhydrase inhibitor
  34. GC17203 Varespladib (LY315920)

    伐瑞拉迪; LY315920

     Inhibitor of group IIA, IIE, and X forms of sPLA2
  35. GC10406 Tosedostat (CHR2797)

    托舍多特,CHR-2797

     An aminopeptidase inhibitor
  36. GC11366 UK 383367

    UK383367, UK-383367

     A potent, selective BMP1 inhibitor
  37. GC17867 Pyrimethamine

    乙胺嘧啶; Pirimecidan; Pirimetamin; RP 4753

     A dihydrofolate reductase inhibitor
  38. GC11273 Anagrelide HCl

    盐酸阿那格雷; BL4162A

     A PDE3 inhibitor
  39. GC17107 PluriSIn #1 (NSC 14613)

    NSC 14613

     A selective inhibitor of stearoyl-CoA desaturase
  40. GC12919 Pralatrexate

    普拉曲沙

     A dihydrofolate reductase inhibitor
  41. GC10077 S- (+)-Rolipram

    (+)-Rolipram; (S)-Rolipram

     S- (+)-Rolipram ((+)-Rolipram) 是一种环状 AMP(cAMP) 特异性磷酸二酯酶 4 (PDE4) 抑制剂，IC50 为 1100 nM。
  42. GC14783 Trilostane

    曲洛司坦; Win 24540

     A 3β-hydroxysteroid dehydrogenase inhibitor
  43. GC10405 Methotrexate

    甲氨蝶呤; Amethopterin; CL14377; WR19039

     甲氨蝶呤（Methotrexate）是一种抗叶酸类抗代谢药，有效抑制二氢叶酸还原酶（DHFR）活性，IC50约为7nM。
  44. GC12764 Aminophylline

    氨茶碱

     A phosphodiesterase inhibitor and adenosine receptor antagonist
  45. GC11681 MK-8245 A stearoyl-CoA desaturase inhibitor
  46. GC15757 Ozagrel

    奥扎格雷; OKY-046

     A selective inhibitor of TXA synthase
  47. GC13652 Dyphylline

    二羟丙茶碱; Diprophylline

     An adenosine receptor antagonist and phosphodiesterase inhibitor
  48. GC17467 Gimeracil

    吉美嘧啶; Gimestat

     A DYPD inhibitor
  49. GC13130 Apixaban

    阿哌沙班; BMS-562247-01

     An inhibitor of Factor Xa
  50. GC12808 Pimobendan

    匹莫苯丹; UD-CG115

     An inhibitor of PDE3
  51. GC10531 AGI-5198

    AGI5198, AGI 5198

     A potent, selective inhibitor of IDH1 mutations

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