Metabolism(代谢)
- PPAR(183)
- 5-alpha Reductase(10)
- 5-Lipoxygenase(11)
- Adenosine Deaminase(10)
- Aminopeptidase(13)
- C14ɑ demethylase(2)
- Carbonic Anhydrase(47)
- CETP(9)
- Cholesterol absorption(1)
- CPT1(2)
- CYP3A/CYP450(18)
- Dehydrogenase(40)
- DHFR(6)
- DGAT(7)
- Dopamine β-hydroxylase(10)
- Enolase(4)
- FAAH(33)
- Factor Xa(41)
- Ferroptosis(161)
- Folate Analogue(2)
- Glucokinase(16)
- HMG-CoA Reductase(34)
- HSP(87)
- IDO(45)
- KRAS-PDEδ(3)
- MAO(6)
- Neuronal Metabolism(8)
- Oxidative Phosphorylation(22)
- P450(356)
- PDE(220)
- Phospholipase(112)
- Procollagen C Proteinase(1)
- Saccharometabolism(1)
- SCD(16)
- SGLT(26)
- TPH(4)
- Transferase(26)
- ALP(1)
- Carbohydrates(21)
- Transaminase(3)
- Catalase(7)
- monooxygenase(1)
- PKM2(1)
- Aldehyde dehydrogenase(1)
- Squalene synthase(1)
- Hydrolase(16)
- ornithine decarboxylase(1)
- Amino acid metabolism(3)
- phosphatases(92)
- Pyruvate kinase(8)
- Others(64)
- MGL(1)
- Galactosidase(2)
- 12-Lipoxygenase(1)
- Fatty Acid Synthase (FASN)(8)
- Dihydroorotate Dehydrogenase(12)
- Bile Acids & Microbiome(93)
- Bone Growth & Remodeling(35)
- Carbohydrate Metabolism(126)
- Cofactors & Vitamins(64)
- Dyslipidemias(73)
- Inborn Errors of Metabolism(80)
- Metabolic Syndrome(16)
- Necroptosis(9)
- Necrosis(14)
- Nutrient Sensing(12)
- Phosphodiesterase(27)
- Reproductive Biology(124)
- Thermogenesis(6)
- Sterol Biosynthesis(28)
- Prolyl Hydroxylation Enzymes(1)
- Biliary System(4)
- Metabolic Disease(4)
- Fat Mass and Obesity-associated Protein (FTO)(2)
- SHIP(1)
- Cat.No. 产品名称 Information
- GC68034 Enoxaparin Enoxaparin (PK 10169) 是一种低分子肝素 (LMWH) 衍生物。Enoxaparin 通过抗凝血酶 III 发挥其抗凝血 (anticoagulant) 活性,抗凝血酶 III 是一种内源性 Xa 因子和凝血酶 IIa (thrombin IIa) 的抑制剂。Enoxaparin 可通过抗氧化 (antioxidant) 和抗炎 (anti-inflammatory) 作用保护大鼠海马区免受 TBI 损伤。Enoxaparin 可用于深静脉血栓形成 (DVT)、肺栓塞、外伤性脑损伤 (TBI) 和 COVID-19 的研究。
- GC68003 Cadisegliatin Cadisegliatin (TTP-399) 是一种潜在的肝脏选择性葡萄糖激酶 (GK) 激活剂,具有口服活性。Cadisegliatin 具有降血糖活性,Cadisegliatin 可用于 2 型糖尿病的研究。
- GC67997 Aminopeptidase-IN-1 Aminopeptidase-IN-1 (compound 16o) 是一种有效的胰岛素调节氨肽酶 (IRAP) 抑制剂,Ki 为 7.7 μM。Aminopeptidase-IN-1 可用于研究认知和记忆障碍。
- GC67967 Dovramilast Dovramilast (CC-11050) 是一种磷酸二酯酶 4 (PDE4) 抑制剂,具有口服活性,可以减少炎症反应,改善 Isoniazid 介导的肺部细菌清除。Dovramilast 作为辅助试剂,可用于结核病的研究。
- GC67933 LKY-047 LKY-047,是 Decursin 的一种衍生物,是一种有效的选择性的可逆竞争性的细胞色素 P45022J2 (CYP2J2) 抑制剂,IC50 为 1.7 μM。LKY-047 对其他人类 P450 无效,例如 CYP1A2、CYP2A6、CYP2B6、CYP2C8、CYP2C9、CYP2C19、CYP2D6、CYP2E1 和 CYP3A。
- GC67916 Palmitic acid-d4 Palmitic acid-d4 是 Palmitic acid 的氘代物。Palmitic acid 一种常见于动物和植物中的长链饱和脂肪酸。Palmitic acid 以诱导小鼠颗粒细胞中葡萄糖调节蛋白 78 (GRP78) 和 CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达。
- GC67909 GSK2647544 GSK2647544 是一种口服的、选择性的 Lp-PLA2 抑制剂。Lp-PLA2是一种钙非依赖性磷脂酶 A2,具有促炎活性,主要由单核细胞衍生的巨噬细胞分泌。
- GC67901 Glucokinase activator 3 Glucokinase activator 3 是一种有效的且完全的葡萄糖激酶 Glucokinase (GK) 激活剂,其 AC50 为 38 nM. Glucokinase activator 3 具有研究 2 型糖尿病的潜力。
- GC67894 FASN-IN-5 FASN-IN-5 (example 11) 是 FASN 抑制剂,可用于研究 TH17 或 CSF1 介导的疾病或障碍,例如癌症、免疫障碍和肥胖症。
- GC67866 PPARδ/γ agonist 1 sodium PPARδ/γ agonist 1 sodium 是一种化学性质独特,可透过血脑屏障的双重 PPAR delta/gamma 激动剂。PPARδ/γ agonist 1 sodium 可用于老年痴呆症的研究。
- GC67864 (R)-Irsenontrine (R)-Irsenontrine ((R)-E2027) 是 Irsenontrine 的 R 型异构体,是一种有效的磷酸二酯酶 9 (PDE9) 抑制剂,抑制其 IC50 值为 0.041 μM。(R)-Irsenontrine 可用于神经系统疾病的研究。
- GC67714 DP00477 DP00477 是一种有效的 IDO1 (indoleamine 2,3-dioxygenase 1) 抑制剂,IC50 值为 7.0 µM。DP00477 具有癌症研究的潜力。
- GC52513 Indolimine-214 A genotoxic gut microbiota metabolite
- GC52504 Human Vitamin D Receptor Reporter Assay System A nuclear receptor cell-based reporter assay
- GC52497 Lactosylceramide (porcine RBC) A sphingolipid
- GC52496 Sulfatide (bovine) (sodium salt) A mixture of isolated bovine sulfatides
- GC52493 Glucosylceramide (bovine buttermilk) A sphingolipid
- GC52492 Globotriaosylceramide (hydroxy) (porcine RBC) A sphingolipid
- GC52491 Globotriaosylceramide (non-hydroxy) (porcine RBC) A sphingolipid
- GC52428 10-oxo-12(Z)-Octadecenoic Acid-d5 An internal standard for the quantification of 10-oxo-12(Z)-octadecenoic acid
- GC52421 (±)-10-hydroxy-12(Z)-Octadecenoic Acid-d5 An internal standard for the quantification of (±)-10-hydroxy-12(Z)-octadecenoic acid
- GC52420 Drospirenone-13C3 An internal standard for the quantification of drospirenone
- GC52413 5-Aminosalicylic Acid-d7 An internal standard for the quantification of 5-aminosalicylic acid
- GC52409 BAM-22P (8-22) (human, mouse, rat, bovine) (trifluoroacetate salt) A neuropeptide and MRGPRX1 agonist
- GC52404 γ-Glu-Phe (trifluoroacetate salt) A dipeptide with metabolism-altering activity
- GC52400 γ-Glu-Ala (trifluoroacetate salt) A dipeptide
- GC52390 Spexin 1 (human, mouse, rat, bovine) (acetate) An endogenous peptide and agonist of GAL2 and GAL3
- GC52384 NFAT Inhibitor (cell-permeable) (trifluoroacetate salt) A cell-permeable form of NFAT inhibitor
- GC52376 BMP2-derived Peptide (trifluoroacetate salt) A synthetic peptide
- GC52361 AMARA Peptide (trifluoroacetate salt) A peptide substrate for AMPK
- GC52351 Citrullinated α-Enolase (R8 + R14) (1-19)-biotin Peptide A biotinylated and citrullinated α-enolase peptide
- GC52329 Betamethasone-d5 An internal standard for the quantification of betamethasone
- GC52324 3-(3-Hydroxyphenyl)propionic Acid sulfate A metabolite of certain phenols and glycosides
- GC52323 L-Isoleucine-13C6 An internal standard for the quantification of L-isoleucine
- GC52318 Oleic Acid-13C5 An internal standard for the quantification of oleic acid
- GC52317 BCP-T.A. A ferroptosis inducer
- GC52315 GK241 An sPLA2 (Type IIA) inhibitor
- GC52304 Perfluoroheptanoic Acid A perfluoroalkyl substance
- GC52290 (R)-HTS-3 An inhibitor of LPCAT3
- GC52278 Creatine Phosphate (sodium salt hydrate) A phosphorylated form of creatine
- GC52257 Perfluorohexanoic Acid A perfluoroalkyl substance
- GC52253 α-Enolase (1-19)-biotin Peptide A biotinylated α-enolase peptide
- GC52251 Imidacloprid Impurity 1 A potential impurity in commercial preparations of imidacloprid
- GC52231 Heptadecanoyl-L-carnitine-d3 (chloride) An internal standard for the quantification of heptadecanoyl-L-carnitine
- GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone An active metabolite of various polyphenols
- GC52219 Heptadecanoyl-L-carnitine (chloride) A long-chain acylcarnitine
- GC52214 Nicotinamide riboside-d4 (triflate) An internal standard for the quantification of nicotinamide riboside
- GC67661 S-2E S-2E 是一种具有口服活性且非竞争性的 HMG-CoA 还原酶和乙酰-CoA 羧化酶 (acetyl-CoA carboxylase) 抑制剂。S-2E 具有抗高血脂作用,可用于家族性高胆固醇血症和混合性高脂血症的研究。
- GC67211 BAPTA tetrapotassium An extracellular calcium chelator
- GC66645 L-Adenosine L-Adenosine 是一种代谢稳定的对映异构体类似物,也是一种潜在的探针。L-Adenosine 具有弱抑制性腺苷脱氨酶 (ADA) 活性,Ki 值为 385 μM。L-Adenosine 可用于腺苷摄取和积累的研究。