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Home >> Signaling Pathways >> Tyrosine Kinase

Tyrosine Kinase(酪氨酸激酶)

  1. Cat.No. 产品名称 Information
  2. GC19330 SGI-7079

    3-[2-[[3-氟-4-(4-甲基-1-哌嗪基)苯基]氨基]-5-甲基-7H-吡咯并[2,3-D]嘧啶-4-基]苯乙腈

     An Axl kinase inhibitor
  3. GC19321 Savolitinib

    赛沃替尼; Volitinib; HMPL-504; AZD-6094

     An inhibitor of c-Met
  4. GC19317 S49076 S49076 是一种新型、有效的 MET、AXL/MER 和 FGFR1/2/3 抑制剂，IC50 值低于 20 nM。
  5. GC19287 PF06650833

    PF-06650833

     PF06650833 (PF-06650833) 是一种有效的、选择性的和口服活性的白细胞介素 1 受体相关激酶 4 (IRAK4) 抑制剂，在细胞和 PBMC 试验中的 IC50 分别为 0.2 和 2.4 nM。
  6. GC19279 PD-166866 A potent inhibitor of FGFR1
  7. GC19256 MTX-211

    Mol 211

     MTX-211 (Mol 211) 是 EGFR 和 PI3K 的双重抑制剂，IC50 值 <100 nM。 MTX-211可用于癌症和其他疾病的研究。
  8. GC19218 Lazertinib

    YH25448; GNS-1480

     An irreversible inhibitor of mutant EGFRs
  9. GC19205 JH-II-127 An inhibitor of wild-type and mutant forms of LRRK2
  10. GC19187 H3B-6527 An FGFR4 inhibitor
  11. GC19179 GSK2256098 A FAK inhibitor
  12. GC19166 Glesatinib hydrochloride

    MGCD265 hydrochloride

     Glesatinib hydrochloride (MGCD265 hydrochloride) 是一种具有口服活性的强效 MET/SMO 双重抑制剂。 Glesatinib hydrochloride 是一种酪氨酸激酶抑制剂，可拮抗 P-糖蛋白 (P-gp) 介导的非小细胞肺癌 (NSCLC) 中的多药耐药 (MDR)。
  13. GC19158 FLT3-IN-2 An inhibitor of FLT3, c-Kit, and c-FMS
  14. GC19156 TAS-120

    TAS-120

     An orally bioavailable, irreversible inhibitor of FGFRs
  15. GC19155 FGFR4-IN-1 An inhibitor of FGFR4
  16. GC19154 Roblitinib

    8-二氮杂萘-1(2H)-甲酰胺,FGF-401

     Roblitinib (FGF-401) 是一种 1,8-naphthyridine 吡啶衍生物。
  17. GC19142 Erdafitinib

    厄达替尼; JNJ-42756493

     A pan-FGFR inhibitor
  18. GC19140 X-376

    恩沙替尼

     An ALK inhibitor
  19. GC19132 EGFR-IN-3 EGFR-IN-3 是第三代 EGFR TKI，GI50 值分别为 5 nM (EGFR L858R/T790M)、10 nM (EGFR del19) 和 689 nM (EGFR WT)。 EGFR-IN-3 具有用于 NSCLC 研究的潜力。
  20. GC19108 SCR-1481B1

    麦他替尼胺丁三醇,c-Met inhibitor 2

     A pyridone
  21. GC19102 CEP-40783

    RXDX-106

     A multi-kinase inhibitor
  22. GC19092 CCT241736 A dual inhibitor of Aurora kinases and FLT3
  23. GC19084 Brigatinib

    布格替尼; AP-26113

     An orally bioavailable ALK inhibitor
  24. GC19080 BPR1J-097 An FLT3 inhibitor
  25. GC19075 BLU-554

    BLU-554

     A potent inhibitor of FGFR4
  26. GC19074 Avapritinib

    阿伐普替尼,BLU-285

     A dual inhibitor of KIT and PDGFRα mutant kinases
  27. GC19066 BGB-283 BGB-283 is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively.
  28. GC19063 Belizatinib

    TSR-011

     An ALK inhibitor
  29. GC19062 BBT594

    NVP-BBT594

     BBT594 是一种有效的受体酪氨酸激酶 RET 抑制剂，用于癌症治疗。
  30. GC19044 Avitinib maleate

    艾维替尼马来酸盐; Abivertinib maleate; AC0010 maleate

     A selective inhibitor of mutant EGFR
  31. GC18718 bpV(pic) (potassium hydrate)

    Bisperoxovanadium(pic)

     A PTEN inhibitor
  32. GC18591 GSK805

    N-(2,6-二氯-2'-(三氟甲氧基)-[1,1'-联苯]-4-基)-2-(4-(乙基磺酰基)苯基)乙酰胺

     An RORγt inverse agonist
  33. GC18580 B355252 A neuroprotective agent
  34. GC18492 GSK3179106

    RET Kinase Inhibitor 1

     A RET kinase inhibitor
  35. GC18438 CGP 77675 An inhibitor of Src family kinases
  36. GC18211 Ningetinib

    宁格替尼

     A multi-kinase inhibitor
  37. GC19012 (R)-GNE-140

    (R)-3-((2-氯苯基)硫基)-4-羟基-6-(4-吗啉苯基)-6-(噻吩-3-基)-5,6-二氢吡啶-2(1H)-酮

     (R)-GNE-140 是一种有效的乳酸脱氢酶 A (LDHA) 抑制剂，对 LDHA 和 LDHB 的 IC50 分别为 3 nM 和 5 nM； (R)-GNE-140 的效力是 S 对映体的 18 倍。
  38. GC18168 JI-101

    CGI1842

     An inhibitor of VEGFR2, PDGFRβ, and EphB4
  39. GC18167 AC710

    N-[4-[[[[5-(叔丁基)-3-异恶唑基]氨基]羰基]氨基]苯基]-5-[(1-乙基-2,2,6,6-四甲基-4-哌啶基)氧基]-2-吡啶甲酰胺

     A PDGFR family kinase inhibitor
  40. GC11737 AG957

    NSC 654705,Tyrphostin AG957

     An inhibitor of Bcr-Abl and c-Abl
  41. GC16235 AG-1295

    酪氨酸磷酸化抑制剂AG1295,NSC 380341,Tyrphostin AG-1295

     A selective inhibitor of PDGF receptor kinase
  42. GC12864 AG-1557

    Tyrphostin AG-1557

     An EGFR inhibitor
  43. GC15365 N-Acetylserotonin

    N-乙酰-5-羟色胺,N-Acetyl-5-hydroxytryptamine,NAS

     The immediate precursor of melatonin
  44. GC14951 Meleagrin

    6-O-Methyloxaline

     A Fabl inhibitor
  45. GC12461 HA-100 (hydrochloride)

    C-1

     An inhibitor of PKA, PKC, and PKG
  46. GC14890 AG-183

    酪氨酸磷酸化抑制剂A51,Tyrphostin 51

     An inhibitor of EGF receptor kinase
  47. GC12251 Tandutinib (MLN518) HCl FLT3 inhibitor,potent and selective
  48. GC13988 HNMPA

    Hydroxy-2-naphthalenylmethyl Phosphonic Acid

     An insulin receptor tyrosine kinase inhibitor
  49. GC11024 AG-213

    酪氨酸磷酸化抑制剂,Tyrphostin AG-213,Tyrphostin 47

     An inhibitor of EGF receptor kinase
  50. GC10217 RG-14620

    Tyrphostin RG14620

     An inhibitor of EGF receptor kinase
  51. GC11845 AG-82

    酪氨酸磷酸化抑制剂25,NSC 676484,RG-50875,Tyrphostin 25,Tyrphostin AG-82

     An inhibitor of EGF receptor kinase

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