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HNMPA Sale

(Synonyms: Hydroxy-2-naphthalenylmethyl Phosphonic Acid) 目录号 : GC13988

An insulin receptor tyrosine kinase inhibitor

HNMPA Chemical Structure

Cas No.:132541-52-7

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1mg
¥444.00
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5mg
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10mg
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25mg
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Sample solution is provided at 25 µL, 10mM.

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产品描述

HNMPA is a tyrosine kinase inhibitor that inhibited both the receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity [1].

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for growth factors, cytokines, and hormones. The insulin receptor is one of a number of growth factor receptors with intrinsic tyrosine kinase activity that can be activated upon ligands binding [1].

HNMPA (Hydroxy-2-naphthalenylmethyl Phosphonic Acid) is a tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation. HNMPA does not affect protein kinase C or cyclic AMP-dependent protein kinase activities. HNMPA inhibited tyrosine kinase activity of autophosphorylated insulin receptor towards poly (Glu4, Tyr) or insulin receptor-(1155-1165) peptide by 82% and 81%, respectively. HNMPA also inhibited autophosphorylation of insulin receptors by 13% + 4.6% in the presence of insulin. HNMPA not only inhibited insulin receptor tyrosine phosphorylation but also effectively decreased insulin receptor serine phosphorylation [1]. In β-cells exposed to high glucose, HNMPA was able to further increase the exe-4-induced insulin secretion [2].

References:
[1].  Baltensperger K, Lewis RE, Woon CW, et al. Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7885-9.
[2].  Moon MJ, Kim HY, Park S, et al. Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1. Mol Cells. 2011 Oct;32(4):389-95.

Chemical Properties

Cas No. 132541-52-7 SDF
别名 Hydroxy-2-naphthalenylmethyl Phosphonic Acid
化学名 P-(hydroxy-2-naphthalenylmethyl)-phosphonic acid
Canonical SMILES OC(P(O)(O)=O)C1=CC2=CC=CC=C2C=C1
分子式 C11H11O4P 分子量 238.2
溶解度 ≤20mg/ml in ethanol;1mg/ml in DMSO;15mg/ml in dimethyl formamide 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 4.1982 mL 20.9908 mL 41.9815 mL
5 mM 0.8396 mL 4.1982 mL 8.3963 mL
10 mM 0.4198 mL 2.0991 mL 4.1982 mL
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