Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC10084 Pyridoxal 5 phosphate
磷酸吡哆醛; Pyridoxal 5′-phosphate; Pyridoxyl phosphate
An enzyme cofactor
GC13749 O-Phosphorylethanolamine
乙醇胺磷酸酯,Monoaminoethyl phosphate; NSC 254167; O-Phosphoethanolamine
A phospholipid metabolite
GC11828 N-carbamoyl-DL-aspartic acid
脲基琥珀酸; Ureidosuccinic Acid
An intermediate in pyrimidine biosynthesis
GC15129 N-Acetylneuraminic acid
唾液酸; NANA; Lactaminic acid
An abundant sialic acid
GC17521 N-acetyl D-galactosamine
N-乙酰-D-半乳糖胺
An amino sugar derivative of galactose
GC10292 myo-Inositol
肌醇; myo-Inositol; meso-Inositol
肌醇是一种化合物，许多食物中都含有相关的脂质，特别是水果，尤其是哈密瓜和橙子。
GC10631 Melibiose
蜜二糖
蜜二糖是一种二糖，由一个半乳糖和一个葡萄糖部分组成的 α (1-6) 糖苷键。
GC17814 L-Sorbose
L-山梨糖
A monosaccharide
GC10353 L-homocystine
L-高胱氨酸
L-同型半胱氨酸是 L-同型半胱氨酸的氧化成员。
GC12518 L-Dihydroorotic acid
L-氢化乳清酸
L-二氢乳清酸可以通过二氢乳清酶可逆地水解产生无环L-脲基琥珀酸。
GC10730 L-Arabitol
L-(-)-阿拉伯糖醇
L-Arabitol 是红薯、鹿莓、蛾豆等食品消耗的潜在生物标志物，还与阿尔茨海默病和 5-磷酸核糖异构酶缺乏症有关。
GC13084 Ketoisovaleric acid
3-甲基-2-氧丁酸
Ketoisovaleric acid（KIV）是亮氨酸和缬氨酸合成的前体。
GC12809 Itaconic acid
衣康酸
Itaconic acid是一种不饱和二羧酸，可由原核生物和真菌合成，也可在哺乳动物巨噬细胞感染过程中由乌头酸脱羧酶1（ACOD1，也称为IRG1）产生和分泌。
GC16949 Guanine
鸟嘌呤

A purine base
GC15388 Glyoxylic acid
乙醛酸,NSC 27785; Formylformic acid; Oxalaldehydic acid

乙醛酸 (NSC 27785) 是一种既是醛又是羧酸的有机化合物。
GC17170 gamma-Glu-Cys
G-谷氨酸-半胱氨酸,γ-Glutamylcysteine
gamma-Glu-Cys是由谷胱甘肽合成酶产生的二肽。
GC14331 Folinic acid
亚叶酸; leucovorin
亚叶酸 (Leucovorin) 是一种生物叶酸，通常与甲氨蝶呤 (MTX) 一起作为救援剂给药，以降低 MTX 诱导的毒性。
GC13392 Flavin adenine dinucleotide
黄素腺嘌呤二核苷酸; FAD
Flavin adenine dinucleotide（黄素腺嘌呤二核苷酸，FAD）是一种重要的氧化还原辅因子，广泛参与细胞的能量代谢和电子传递过程。
GC13531 Deoxyadenosine 5-triphosphate
2'-脱氧腺苷5'-三磷酸酯,dATP
Deoxyadenosine 5-triphosphate是一种由一个腺嘌呤碱基、一个脱氧核糖和三个磷酸基团组成的脱氧核苷酸三磷酸。
GC16449 Cellobiose
D-纤维二糖
A disaccharide
GC16971 β-Nicotinamide mononucleotide
烟酰胺单核苷酸; β-NM; NMN
β-烟酰胺单核苷酸是烟酰胺磷酸核糖转移酶（NAMPT）反应的产物，也是关键的NAD+中间体。
GC17558 Adenosine 5'-triphosphate disodium salt hydrate
腺苷5'-三磷酸二钠盐水合物,Adenosine 5'-triphosphate disodium salt hydrate

Adenosine 5'-triphosphate disodium salt hydrate (Adenosine 5'-triphosphatedisodium salt hydrate) 是体内能量储存和代谢的核心成分，提供代谢能量以驱动代谢泵，并作为细胞中的辅酶。
GC13172 Adenosine 5-monophosphate
腺苷酸; AMP
5-单磷酸腺苷是调节能量稳态和信号转导的关键细胞代谢物。
GC10067 6-Hydroxynicotinic acid
6-羟基烟酸
6-羟基烟酸是一种内源性代谢物。
GC11270 4-Hydroxybenzoic acid
对羟基苯甲酸
A phenolic acid
GC10996 4-Aminobenzoic acid
对氨基苯甲酸; PABA; Vitamin Bx; Vitamin H1; p-Aminobenzoic acid
A biosynthetic intermediate
GC16812 3-Methylglutaric acid
3-甲基戊二酸
A metabolite of L-leucine
GC14549 3-Hydroxyphenylacetic acid
3-羟基苯乙酸
A phenolic acid with diverse biological activities
GC13571 2-Deoxyuridine
2'-脱氧尿苷; 2-脱氧尿苷
A pyrimidine nucleoside
GC11581 2-Deoxyinosine
2'-脱氧肌苷
A nucleoside form of hypoxanthine
GC12850 2-Deoxy-D-ribose
2-脱氧-D-核糖
A reducing sugar
GC17436 2'-Deoxycytidine-5'-monophosphoric acid
2'-脱氧胞苷-5'-单磷酸
A deoxyribonucleotide
GC17478 2-Deoxycytidine
2'-脱氧胞苷; Deoxycytidine; Cytosine deoxyriboside; Deoxyribose cytidine
A deoxyribonucleoside
GC11642 2-Deoxyadenosine
2'-脱氧腺苷
2-Deoxyadenosine 是一种核苷腺苷衍生物，与双链 DNA 中的脱氧胸苷 (T) 配对。
GC12964 2-3-Dihydroxybenzoic acid
2,3-二羟基苯甲酸; Catecholcarboxylic acid; NSC 27435
2-3-二羟基苯甲酸是一种在血浆中发现的正常人体苯甲酸代谢物，在服用阿司匹林后水平会升高。
GC10156 o-Phenanthroline
1,10-菲罗啉
o-Phenanthroline是一种常用的有机螯合剂和配体，能与多种金属离子（如Fe²⁺、Zn²⁺）形成稳定的配合物。
GC11553 2-cyano-Pyrimidine
2-氰基嘧啶
A cathepsin K inhibitor
GC14411 Apoptozole
Apoptosis Activator VII
An inhibitor of Hsp70
GC10572 Equisetin
尹奎色亭
An HIV-1 integrase inhibitor
GC13877 1,2-Dipalmitoyl-sn-glycerol
1,2-双棕榈酸甘油酯,1,2-DPG,NSC 269964
A diacylglycerol
GC10149 cis-ACCP A matrix metalloproteinase inhibitor
GC16375 (±)-Jasmonic Acid methyl ester
甲基茉莉酮酸酯,(±)-Methyl Jasmonate
A plant growth regulator
GC13421 UCF 101 An Omi/HtrA2 protease inhibitor
GC11988 15-acetoxy Scirpenol
15-乙酰蛇形菌素
A trichothecene mycotoxin
GC10661 Destruxin B
黑僵菌素 B
An insecticidal mycotoxin
GC10408 2-D08 An inhibitor of sumoylation
GC11989 Nortriptyline (hydrochloride)
盐酸去甲替林; Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride
A tricyclic antidepressant
GC12088 BAY-678 A selective, cell permeable inhibitor of human neutrophil elastase
GC11969 Adenosine-5'-diphosphate
二磷酸腺苷,Adenosine Pyrophosphate,ADP,5′-ADP
Adenosine-5'-diphosphate是 P2Y1、P2Y12、P2Y13 等嘌呤能 P2Y 受体的天然激动剂，可直接结合并触发下游信号级联。
GC17245 MMP-13 Inhibitor
N4,N6-双(4-氟-3-甲基苄基)嘧啶-4,6-二甲酰胺,Collagenase-3 Inhibitor,Matrix Metalloproteinase-13 Inhibitor,4,6-Pyrimidinedicarboxamide
A selective MMP-13 inhibitor