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Adenosine-5'-diphosphate Sale

(Synonyms: 二磷酸腺苷,Adenosine Pyrophosphate,ADP,5′-ADP) 目录号 : GC11969

ATP precursor and purinergic receptor ligand

Adenosine-5'-diphosphate Chemical Structure

Cas No.:58-64-0

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Sample solution is provided at 25 µL, 10mM.

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IC50: 67 nM for P2X2/3

Adenosine-5'-diphosphate is an agonist of purinergic receptors.

Purinergic receptors, also known as purinoceptors, are a family of plasma membrane molecules that are found in almost all mammalian tissues. Within the field of purinergic signalling, these receptors have been implicated in learning and memory, locomotor and feeding behavior, and sleep. More specifically, purinergic receptors are involved in several cellular functions, such as proliferation and migration of neural stem cells, vascular reactivity, apoptosis and cytokine secretion.

In vitro: Adenosine 5'-diphosphate (ADP) is an adenine nucleotide having two phosphate groups esterified to the sugar moiety at the 5’ position. ADP is formed through dephosphorylation of adenosine 5’-triphosphate (ATP) by ATPases and can be converted back to ATP by ATP synthases. ADP can also be metabolized to adenosine 5’-monophosphate (AMP) and 2’-deoxyadenosine 5’-diphosphate (dADP). ADP can modulate several receptors, such as activating certain purinergic receptors and inhibiting others, inhibiting rat ecto-5’nucleotidase (Ki = 0.91 nM), as well as regulating the phosphorylation status of AMP-activated protein kinase [1, 2].

In vivo: Up to now, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

IC50: P2X2/3为67 nM

腺苷酸二钠是嘌呤能受体的一种激动剂。

嘌呤能受体,也称为嘌呤受体,是一类存在于几乎所有哺乳动物组织中的质膜分子。在嘌呤能信号传导领域,这些受体被认为与学习和记忆、运动和进食行为以及睡眠等方面有关。更具体地说,嘌呤能受体参与了多种细胞功能,例如神经干细胞的增殖和迁移、血管反应性、细胞凋亡和细胞因子分泌。

体外实验:腺苷酸二钠(ADP)是一种腺嘌呤核苷酸,其两个磷酸基被酯化到5'位的糖基上。ADP通过ATP酶的去磷酸化形成,可以通过ATP合成酶转化回ATP。ADP还可以代谢成腺苷酸单钠(AMP)和2'-去氧腺苷酸二钠(dADP)。ADP可以调节多种受体,例如激活某些嘌呤能受体并抑制其他受体,抑制大鼠外泌5'nucleotidase(Ki = 0.91 nM),以及调节AMP-激活蛋白激酶的磷酸化状态 [1, 2]。

体内实验:目前还没有报告动物体内数据。

临床研究:目前还没有进行任何临床研究。

References:
1.  Azran, S.,Frster, D.,Danino, O., et al. Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonists. J. Med. Chem. 56(12), 4938-4952 (2013).
2.  Jarvis, M.F.,Bianchi, B.,Uchic, J.T., et al. [3H]A-317491, a novel high-affinity non-nucleotide antagonist that specifically labels human P2X2/3 and P2X3 receptors. Journal of Pharmacology and Experimental Therapeutics 310(1), 407-416 (2004).

Chemical Properties

Cas No. 58-64-0 SDF
别名 二磷酸腺苷,Adenosine Pyrophosphate,ADP,5′-ADP
化学名 adenosine 5'-(trihydrogen diphosphate)
Canonical SMILES O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(O)(O)=O)(O)=O)[C@H]1O
分子式 C10H15N5O10P2 分子量 427.2
溶解度 ≥ 21.35mg/mL in DMSO with gentle warming 储存条件 Store at -20°C,protect from light
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mM 2.3408 mL 11.7041 mL 23.4082 mL
5 mM 0.4682 mL 2.3408 mL 4.6816 mL
10 mM 0.2341 mL 1.1704 mL 2.3408 mL
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