Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC18423 IDH305 A potent and selective inhibitor of mutant IDH1
GC18417 4-hydroxy Xylazine
4-羟基塞拉嗪
A xylazine metabolite
GC18408 BML-278
DIETHYL1-BENZYL-4-PHENYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE锛圵S201542锛,WUXIAPPTEC"
An activator of SIRT1, SIRT2, and SIRT3
GC18398 Sitostanol
豆甾烷醇
A saturated plant sterol
GC18389 9-cis Retinal
9-顺式视黄醛

A natural retinoid
GC18359 4-Epianhydrochlortetracycline (hydrochloride)
4-差向四环素盐酸盐
An inhibitor of MMP-9
GC18335 6β-hydroxy Dexamethasone
6-羟基地塞米松
A metabolite of dexamethasone
GC18315 Calpain Inhibitor VI
SJA6017
A calpain and cathepsin inhibitor
GC18289 Lathosterol
Δ7-Cholestenol, γ-Cholestenol
An intermediate in the biosynthesis of cholesterol
GC18274 Amiprofos-methyl
甲基胺草磷,BAY-NTN 6867
An herbicide
GC18256 PF-06281355
PF-06281355
A myeloperoxidase inhibitor
GC18249 NQ301 A naphthoquinone with diverse biological activities
GC18232 Prostaglandin D2
前列腺素D2,PGD2

A major prostaglandin produced by mast cells
GC18224 Cholesterol α-Linolenate
胆甾烯基亚麻酸酯,Cholesteryl Linolenate
A cholesterol ester
GC18219 6-hydroxy Warfarin
3-(Α-丙酮基苄基)-4,6-二羟基香豆素
A phase I metabolite of (+)-warfarin
GC18194 4-Epidoxycycline
强力霉素
A metabolite of doxycycline
GC18188 MPP+ Iodide
1-甲基-4-苯基吡啶鎓碘化物
MPP+ Iodide（1-methyl-4-phenylpyridinium iodide）是神经毒素 MPTP 的一种有毒代谢物，通过选择性破坏黑质中的多巴胺能神经元，在体外模型中成功诱导了帕金森样综合征。
GC18183 Nifurtimox
硝呋替莫
An antiprotozoal agent
GC18173 TM5441 A PAI-1 inhibitor
GC18170 ML-346 An activator of the heat shock response
GC19012 (R)-GNE-140
(R)-3-((2-氯苯基)硫基)-4-羟基-6-(4-吗啉苯基)-6-(噻吩-3-基)-5,6-二氢吡啶-2(1H)-酮
(R)-GNE-140 是一种有效的乳酸脱氢酶 A (LDHA) 抑制剂，对 LDHA 和 LDHB 的 IC50 分别为 3 nM 和 5 nM； (R)-GNE-140 的效力是 S 对映体的 18 倍。
GC11912 PF-04929113 (SNX-5422)
SNX-5422
A prodrug for an Hsp90 inhibitor
GC13414 AT13387
AT13387

A selective inhibitor of Hsp90
GC16165 T-5224
T-5224 是一种非肽类小分子 AP-1 抑制剂，特异性抑制 AP-1 与启动子区 AP-1 结合位点的结合，最初开发为抗炎药用于治疗类风湿性关节炎 (RA) 抑制炎症细胞因子和 MMPs 而没有任何副作用。
GC12861 Z-VAD-FMK
氟甲基酮,Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone,Z-Val-Ala-Asp(OMe)-FMK
Z-VAD-FMK（苄氧羰基-Val-Ala-Asp（OMe）氟甲基酮），是一种类似ICE的蛋白酶抑制剂，通过阻止CPP32转化为其活性形式来抑制细胞凋亡。
GC15168 Urolithin A
尿石素A
Urolithin A是由鞣花酸和鞣花单宁代谢产生的一种活性成分，可作为酪氨酸酶（IC₅₀值为71.44±10.07µmol/L）和单胺氧化酶A（IC₅₀值为29.41±9.01µmol/L）的强效抑制剂。
GC16403 2-Arachidonoyl Glycerol
2-花生酰基甘油乙腈溶液,2-AG

Endogenous CB₁ and CB₂ receptor agonist
GC11941 Flavin adenine dinucleotide disodium
黄素腺嘌呤二核苷酸二钠盐; FAD disodium salt; FAD-Na2; FAD
Flavin adenine dinucleotide（黄素腺嘌呤二核苷酸，FAD）是一种重要的氧化还原辅因子，广泛参与细胞的能量代谢和电子传递过程。
GC11357 Dihomo-γ-Linolenic Acid
顺式-8，11，14-二十烷三烯酸甲酯,all-cis-8,11,14-Eicosatrienoic acid
ω-6 fatty acid intermediate
GC14870 OSMI-1 OSMI-1是一种O-GlcNAc转移酶（OGT）小分子抑制剂，不会显著影响其他糖基转移酶。
GC13377 3-hydroxy Anthranilic Acid
3-羟基-2-氨基苯甲酸,3-HAA,NSC 522891
A tryptophan metabolite
GC17809 GSK864 An inhibitor of mutant IDH1
GC13450 PD 145305 An inactive analog of PD 150606
GC13005 MMP-2 Inhibitor II
Matrix Metalloproteinase-2 Inhibitor II
A selective MMP-2 inhibitor
GC16333 Cycloguanil (hydrochloride)
环氯胍盐酸盐
The active metabolite of proguanil
GC17738 MMP-2 Inhibitor I
Matrix Metalloproteinase-2 Inhibitor I,cis-9-Octadecenoyl-N-hydroxylamide,Oleylhydroxamate
A selective MMP-2 inhibitor
GC11038 MMP-2/MMP-9 Inhibitor I
胶原酶,Metalloproteinase-2/Metalloproteinase-9 Inhibitor I
An inhibitor of MMP-2 and MMP-9
GC15682 Chymostatin
胰凝乳蛋白酶抑制剂
Chymostatin是一种选择性强的蛋白酶体糜蛋白酶样活性抑制剂，Chymostatin对胰凝乳蛋白酶和凝乳酶的Ki分别为9.36nM和13.1nM。
GC13967 Tosyllysine Chloromethyl Ketone (hydrochloride)
(3S)-7-氨基-1-氯-3-磺酰氨基-2-庚酮盐酸盐,1-Chloro-3-Toxylamide-7-Amino-L-2-Heptanone,TLCK
A non-selective proteinase inhibitor
GC15365 N-Acetylserotonin
N-乙酰-5-羟色胺,N-Acetyl-5-hydroxytryptamine,NAS
N-Acetylserotonin是褪黑素生物合成中的一个化学中间体，以昼夜节律的方式激活酪氨酸激酶受体B（TrkB）。
GC12479 Calpain Inhibitor XII
Z-L-Nva-CONH-CH2-2-Py
A selective inhibitor of calpain I
GC12223 Z-Asp-CH2-DCB
Z-Asp-2,6-Dichlorobenzoyloxymethyl Ketone
A pan-caspase inhibitor
GC14847 Psoralidin
补骨脂定
A furanocoumarin with anti-cancer activity
GC14953 Spermine
精胺,Gerontine,Musculamine,Neuridine,NSC 268508,1,5,10,14-Tetraazatetradecane
A natural polyamine
GC16200 L-Biopterin
L-生物喋呤,L-erythro-Biopterin,NSC 339699
An intermediate for tetrahydro-L-biopterin
GC10312 Trehalose
D-海藻糖; D-Trehalose; α,α-Trehalose
A natural non-reducing disaccharide
GC13216 trans-trans Muconic acid
反式,反式-1,3-丁二烯-1,4-二羧酸
trans-trans Muconic acid 是一种苯的尿代谢物，已被用作人体接触苯的生物标志物。
GC10577 trans-Aconitic acid
反式乌头酸
反式乌头酸存在于正常人的尿液中，并且有人建议在雷氏综合征和有机酸尿症中存在大量的乌头酸。
GC15457 Pyridoxine
吡哆醇; Pyridoxol
A 4-methanol form of vitamin B₆
GC15994 Pyridoxal hydrochloride
吡哆醛盐酸盐
A transport form of vitamin B₆