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Spermine Sale

(Synonyms: 精胺,Gerontine,Musculamine,Neuridine,NSC 268508,1,5,10,14-Tetraazatetradecane) 目录号 : GC14953

A natural polyamine

Spermine Chemical Structure

Cas No.:71-44-3

规格 价格 库存 购买数量
1g
¥273.00
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5g
¥1,061.00
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10g
¥1,796.00
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25g
¥3,602.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Spermine is an endogenous polyamine involved in cellular metabolism found in all eukaryotic cells. Spermine is required for eukaryotic cell growth and protein synthesis. Spermine functions as physiological blockers of inward rectifier K+ channels [1].

Inward rectifier K+ channels mediate the K+ conductance at resting potential in many types of cell. Inward rectifier K+ channels play an important role in controlling excitability [1].

Spermine blocked cloned inward rectifier K+ channels IRK1 with the IC50 of 31 nM clamped at 50 mV membrane potential [1]. Physiological concentrations of free spermine (10 μM) mediated strong rectification of IRK1 inward rectifier K+ channels even in the absence of free Mg2+ and in IRK1 mutant channels that have no endogenous rectification [1].

High dose level of spermine induced a great number of changes, such as emaciation, aggressiveness, convulsions and paralysis of the hind legs in Wistar rats. Spermine considerably decreased growth, food intake and water intake [3].

References:
[1] Fakler B, Brndle U, Glowatzki E, et al.  Strong voltage-dependent inward rectification of inward rectifier K+ channels is caused by intracellular spermine[J]. Cell, 1995, 80(1): 149-154.
[2] Til H P, Falke H E, Prinsen M K, et al.  Acute and subacute toxicity of tyramine, spermidine, spermine, putrescine and cadaverine in rats[J]. Food and Chemical Toxicology, 1997, 35(3): 337-348.

Chemical Properties

Cas No. 71-44-3 SDF
别名 精胺,Gerontine,Musculamine,Neuridine,NSC 268508,1,5,10,14-Tetraazatetradecane
化学名 N1,N4-bis(3-aminopropyl)-1,4-butanediamine
Canonical SMILES NCCCNCCCCNCCCN
分子式 C10H26N4 分子量 202.3
溶解度 ≤50mg/ml in Water 储存条件 4°C, away from moisture and light
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.9432 mL 24.7158 mL 49.4315 mL
5 mM 0.9886 mL 4.9432 mL 9.8863 mL
10 mM 0.4943 mL 2.4716 mL 4.9432 mL
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