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PD 145305 Sale

目录号 : GC13450

An inactive analog of PD 150606

PD 145305 Chemical Structure

Cas No.:90536-15-5

规格 价格 库存 购买数量
1mg
¥603.00
现货
5mg
¥2,633.00
现货
10mg
¥4,679.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

PD 145305 is an inactive analog of PD 150606, a potent and selective calpains inhibitor [1].

Calpain is a class of cytosolic cysteine protease that is activated by elevated intracellular calcium. Overactivation of calpain has been implicated in the pathophysiology of several degenerative conditions, including stroke, myocardial ischemia, neuromuscular degeneration, and cataract formation [1].

PD 145305 is an inactive analog of PD 150606, a potent and selective calpains inhibitor. PD 150606, an alpha-mercaptoacrylate derivative, inhibited μ-calpain and m-calpain with Ki values of 0.21 and 0.37 μM, respectively. PD 145305 was inactive at concentrations up to 500 μM. In human leukemic Molt-4 cells, PD150606 inhibited a-spectrin proteolysis in a dose-dependent way and virtually eliminated the formation of the 145-kDa fragment at 10 μM, whereas PD145305 did not attenuate a-spectrin breakdown product formation. In fetal rat cerebrocortical cultures subjected to a combination of hypoxia and hypoglycemia, PD150606 significantly inhibited the release of lactate dehydrogenase, whereas PD145305 was ineffective. PD150606, but not PD145305, was found to make cerebral glutamatergic neurons more resistant to hypoxic/hypoglycemic challenge [1].

Reference:
[1].  Wang KK, Nath R, Posner A, et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92.

Chemical Properties

Cas No. 90536-15-5 SDF
化学名 α-mercapto-benzenepropanoic acid
Canonical SMILES OC(C(S)CC1=CC=CC=C1)=O
分子式 C9H10O2S 分子量 182.2
溶解度 ≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide 储存条件 Store at -20°C
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1 mM 5.4885 mL 27.4424 mL 54.8847 mL
5 mM 1.0977 mL 5.4885 mL 10.9769 mL
10 mM 0.5488 mL 2.7442 mL 5.4885 mL
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