Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC30588 Protirelin (Synthetic thyrotropin-releasing factor)
普罗瑞林; Thyrotropin-releasing-hormone; TRH

A tropic hormone
GC30586 (±) Anabasine
八角枫碱
(±)Anabasine是一种肌肉松弛剂，可用于外科手术时肌肉松驰。
GC30564 2-Hydroxy-4-methoxybenzaldehyde
2-羟基-4-甲氧基苯甲醛
A phenol with diverse biological activities
GC30513 4-Butylresorcinol (Butylresorcinol)
4-丁基间苯二酚; Butylresorcinol
4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.
GC30512 Vatiquinone (EPI-743)
α-Tocotrienol quinone; PTC-743; Vatiquinone; NCT04378075
A metabolite of α-tocotrienol with antioxidant and ferroptosis inhibitory activity
GC30505 N-Desmethyl Clomipramine D3 hydrochloride (Desmethylclomipramine D3 hydrochloride)
去甲氯米帕明-D3盐酸盐,Desmethylclomipramine D3 hydrochloride

N-Desmethyl Clomipramine D3 hydrochloride (Desmethylclomipramine D3 hydrochloride) 是氘标记的 N-Desmethyl Clomipramine。
GC30472 Dehydrocholate sodium (Sodium dehydrocholate)
去氢胆酸钠,Sodium dehydrocholate
Sodium Dehydrocholate is a semisynthetic bile acid made from cholic acid. It has been used for stimulation of biliary lipid secretion.
GC30465 L-Carnosine
肌肽; L-肌肽
A dipeptide with diverse biological activities
GC30459 Senecionine (Senecionan-11,16-dione, 12-hydroxy-)
千里光宁,Senecionan-11,16-dione, 12-hydroxy-; Aureine; Senecionin
A pyrrolizidine alkaloid with hepatotoxic properties
GC30449 Fumaric acid
反丁烯二酸
Fumaric acid (Fumarate, 2-Butenedioic acid, Trans-Butenedioic acid) is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food; also a product of the urea cycle.
GC30438 RP 70676 RP70676是一种有效的ACAT抑制剂，能够抑制对大鼠和兔子中的ACAT活性，IC50值分别为25和44nM。
GC30427 ELN 318463 racemate ELN318463racemate是ELN318463的外消旋体。ELN318463是一种选择性的gamma-secretase抑制剂。
GC30421 Enalapril D5 maleate (MK-421 (D5 maleate))
马来酸依那普利D5; MK-421 D5 maleate
An internal standard for the quantification of enalapril
GC30395 DL-Panthenol (DL-Pantothenol)
DL-泛醇; DL-Pantothenol; DL-Pantothenyl alcohol
DL-panthenol (DL-Pantothenol, DL-Pantothenyl alcohol) is a racemic mixture of D and L form of panthenol,a provitamin of B5.
GC30370 Dinoprost (Prostaglandin F2a)
地诺前列素; Prostaglandin F2α; PGF2α
Dinoprost (Prostaglandin F2a)是一种口服有效的强效前列腺素受体（FP 受体）激动剂。Dinoprost刺激子宫肌层活动，放松宫颈，抑制黄体类固醇生成，并通过直接作用诱导黄体溶解。
GC30354 D-Pipecolinic acid
D-哌啶酸
D-Pipecolinicacid是人体液中的一种代谢物。
GC30353 3-Oxopentanedioic acid
1,3-丙酮二羧酸
3-Oxopentanedioic acid (1,3-Acetonedicarboxylic acid; 3-Oxoglutaric acid) is an intermediate for organic compound synthesis.
GC30343 Selenomethionine (Seleno-DL-methionine)
硒代蛋氨酸; Seleno-DL-methionine; DL-Selenomethionine

硒代蛋氨酸（Seleno-DL-methionine）是一种天然存在的含硒氨基酸，是硒的常见天然食物来源。
GC30337 Galactose 1-phosphate
半乳糖-1-磷酸
半乳糖1磷酸是半乳糖-1-磷酸尿苷酰转移酶(GALT)的作用底物,具有细胞毒性,对糖代谢途径中的多种酶有抑制作用.Gal-1-P(1- 16mm;37℃;1h)能刺激大鼠脑Na+,K+-ATP酶。
GC30334 NCX 1000 NCX1000是一种肝特异性NO供体，它来源于熊去氧胆酸。
GC30333 Valerylcarnitine
Valerylcarnitine是一种内源性代谢物，属于短链酰基肉碱。
GC30332 Isovalerylcarnitine
(3R)-3-(3-甲基丁酰氧基)-4-(三甲基铵)丁酸内盐
Isovalerylcarnitine是L-亮氨酸分解代谢的产物。它增加了钙蛋白酶的活性。
GC30329 Stearoylcarnitine Stearoylcarnitine是一种脂肪酸酯脂质分子。
GC30324 Mevalonic acid
3,5-二羟基-3-甲基戊酸,MVA
甲羟戊酸是从头生物合成途径中胆固醇的前体。
GC30316 L-Cystathionine
L-胱硫醚

An intermediate in cysteine synthesis
GC30304 (S)-3-Hydroxybutanoic acid ((S)-β-Hydroxybutanoic acid)
(S)-3-羟基丁酸,(S)-β-Hydroxybutanoic acid; L-(+)-3-Hydroxybutyric acid; L-β-Hydroxybutyric acid

(S)-3-Hydroxybutanoic acid ((S)-β-Hydroxybutanoic acid) 是一种正常的人体代谢物，已发现在缓解抑郁症的老年患者中升高。
GC30301 Turanose
松二糖
Turanose是一种还原性二糖。
GC30298 Butyrylcarnitine
丁酰肉碱
Butyrylcarnitine是血浆中的代谢物，是异常脂质和能量代谢的指标，来改善心脏衰竭的诊断和预后。
GC30293 Arg-AMS Arg-AMS是精氨酸tRNA合成酶(arginyltRNAsynthetase)的有效抑制剂，能够和非核糖体多肽合成酶的A结构域紧密结合。
GC30281 Pyrithioxin (Pyritinol)
吡硫醇; Pyritinol; Pyridoxine disulfide; Vitamin B6 disulfide
Pyrithioxin (Bonifen, Encefabol, Pyritinol, Vitamin B6 disulfide) is a neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity.
GC30278 Cholesteryl oleate
胆固醇油酸酯

A cholesterol ester
GC30277 4',5-Dihydroxyflavone
5,4'-二羟基黄酮
4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.
GC30268 Maltopentaose (Maltopentose)
麦芽五糖; Maltopentose
Maltopentaose (Maltopentose)是一种由五个葡萄糖单元通过α-1,4-糖苷键连接而成的寡糖。Maltopentaose是麦芽糊精中最短的低聚糖，能够用于研究α-乳清蛋白的糖化和磷酸化。
GC30266 L-SelenoMethionine
L-硒代蛋氨酸
A naturally occurring amino acid with antioxidant properties
GC30263 Glucosamine (D-Glucosamine)
氨基葡萄糖; D-Glucosamine; Chitosamine
Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.
GC30258 Menaquinone-4 (Vitamin K2)
四烯甲萘醌,Vitamin K2(MK-4); Menaquinone K4
A homolog of of vitamin K₂
GC30237 Verdiperstat (AZD3241)
AZD3241
Verdiperstat (AZD3241, BHV-3241) is a selective, orally active and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 630 nM. Verdiperstat (AZD3241) can be used in the research of neurodegenerative brain disorders.
GC30219 Azelaic acid (Nonanedioic acid)
壬二酸; Nonanedioic acid
A dicarboxylic acid with diverse biological activities
GC30215 Linoleic acid
亚油酸

An essential ω-6 PUFA
GC30214 Pyruvic aldehyde (~40% in water)
丙酮醛

Pyruvicaldehyde常被用作有机合成中的一种试剂，一种调味剂以及在鞣革中的应用。
GC30210 (R)-3-Hydroxybutanoic acid
(R)-3-羟基丁酸,(R)-(-)-3-Hydroxybutanoic acid; (R)-3-Hydroxybutyric acid
(R)-3-Hydroxybutanoic acid是一种聚羟基丁酸酯（PHB）单体，能够通过与各种羟基脂肪酸反应制备共聚物，具有工业和医药用途。
GC30196 Maltose monohydrate
麦芽糖-水合物
A disaccharide
GC30192 Pyruvic acid (2-Oxopropanoic acid)
丙酮酸; Acetylformic acid
Pyruvic acid (Acetylformic acid) is an important organic chemical intermediate that plays a role in cardiomyocyte pathophysiology and therapy. Pyruvic acid markedly increases the level of lactate dehydrogenase (LDH) and creatine kinase (CK) and reduces the level of Ca2+Mg2+-ATPase and Na+K+-ATPase.
GC30189 5-Hydroxymethyl-2-furancarboxylic acid
5-羟甲基-2-呋喃甲酸
A major metabolite of 5-hydroxymethyl-2-furfural
GC30187 γ-Glu-Phe (γ-Glutamylphenylalanine)
γ-Glutamylphenylalanine
γ-Glu-Phe (γ-Glutamylphenylalanine) (γ-Glutamylphenylalanine) 由解淀粉芽孢杆菌 (GBA) 和米曲霉 (GAO) 合成。
GC30166 Coproporphyrin III (Zincphyrin)
粪卟啉二盐酸盐,Zincphyrin
粪卟啉 III (Zincphyrin) (Zincphyrin) 是一种天然存在的卟啉衍生物，主要存在于尿液中。
GC30165 Perillartine (DL-Perillartine)
紫苏葶,DL-Perillartine
Perillartine (Perilla sugar, Peryllartine) is a sweetener. Perillartine can activation of the Tas1r2 monomeric receptors of human, rhesus monkey and squirrel monkey but not mouse in a species-dependent manner.
GC30148 (S)-b-aminoisobutyric acid
L-3-氨基异丁酸
(S)-b-aminoisobutyricacid是源自胸腺嘧啶和缬氨酸分解代谢的非蛋白质氨基酸。
GC30146 3,4-Dihydroxymandelic acid
3,4-二羟基扁桃酸
3,4-Dihydroxymandelicacid是去甲肾上腺素的代谢产物。
GC30136 2-Ketoglutaric acid
α-酮戊二酸; Alpha-Ketoglutaric acid
An intermediate in the citric acid cycle