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Home >> Signaling Pathways >> Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for  Proteases

  1. Cat.No. 产品名称 Information
  2. GC41380 N-desmethyl Rosiglitazone

    N-去甲罗格列酮

     A major metabolite of rosiglitazone
  3. GC41362 OMDM-1

    (S)Noleoyl Tyrosinol

     An inhibitor of AEA uptake
  4. GC41339 Pioglitazone Ketone

    吡格列酮

     An active metabolite of pioglitazone
  5. GC41325 Mycophenolic Acid β-D-Glucuronide

    霉酸Β-D-葡萄糖醛酸,MPAG，Mycophenolic Acid Glucosiduronate

     A metabolite of mycophenolic acid
  6. GC41322 5-OxoETE methyl ester

    5-KETE methyl ester

     An esterified form of 5-oxoETE
  7. GC41315 (±)-Ketoprofen Glucuronide

    (酮洛芬酰基)-Β-D-葡糖苷酸

     A metabolite of ketoprofen
  8. GC41312 5-hydroxy Omeprazole

    5-羟基奥美拉唑

     A major metabolite of omeprazole
  9. GC41310 5-Octyl-α-ketoglutarate

    αKG octyl ester

     A cell-permeable form of α-ketoglutarate
  10. GC41309 16α-hydroxy Prednisolone

    16alpha-羟基泼尼松龙,OH-PRED

     A stereoselective metabolite of 22(R)-budesonide
  11. GC41300 17β-hydroxy Exemestane

    亚甲基宝丹酮

     An active metabolite of exemestane
  12. GC41289 U-75302 A BLT1 receptor antagonist
  13. GC41283 N-acetyl-D-Glucosamine

    N-乙酰-D-氨基葡萄糖; N-Acetyl-2-amino-2-deoxy-D-glucose

     Monosaccharide derivative of glucose
  14. GC41282 2'-O-Methyladenosine

    2'-O-甲基腺苷

     An adenosine analog
  15. GC41270 N-desmethyl Zolmitriptan

    N-去甲佐米曲坦-D3

     An active metabolite of zolmitriptan
  16. GC41266 Pregnanediol-3-Glucuronide

    Pregnanediol-3α-Glucuronide

     A metabolite of progesterone
  17. GC41258 Spiroxamine

    螺噁茂胺

     A fungicide
  18. GC41252 BI-6C9 An inhibitor of tBid-mediated apoptosis
  19. GC41251 Pirlindole

    坡尔吲哚

     A selective and reversible MAO-A inhibitor
  20. GC41249 p,p'-DDD

    4,4-滴滴滴,4,4'-DDD; p,p'-Dichlorodiphenyl dichloroethane

     A metabolite of DDT
  21. GC41232 Resolvin D3 methyl ester

    RvD3 methyl ester

     A methyl ester form of resolvin D3
  22. GC41231 Resolvin D2 methyl ester

    7(S),16(R),17(S)Resolvin D2 methyl ester, RvD2 methyl ester

     Methyl ester form of RvD2
  23. GC41230 Resolvin D1 methyl ester

    RvD1 methyl ester

     Derivative of resolvin D1
  24. GC41227 17(R)-Resolvin D1 methyl ester

    AspirintriggeredResolvin D1 methyl ester, ATRvD1 methyl ester, 17epiResolvin D1 methyl ester, 17(R)RvD1 methyl ester

     Methyl ester of an aspirin-triggered resolvin
  25. GC41224 6-diazo-5-oxo-L-nor-Leucine

    6-重氮-5-氧代-L-正亮氨酸; L-6-Diazo-5-oxonorleucine; DON

     6-Diazo-5-oxo-L-nor-Leucine (DON)是一种抑制谷氨酰胺酶的谷氨酰胺类似物,是一种选择性的、基于机制的谷氨酰胺酶失活剂。
  26. GC41220 13(S)-HODE methyl ester Hydroxy fatty acid methyl ester
  27. GC41211 Anacardic Acid Diene

    Anacardic Acid 15:2

     A polyunsaturated for of anacardic acid
  28. GC41209 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid

    EFOX, 17-oxo-DPA, 17oxo7(Z),10(Z),13(Z),15(E),19(Z)DPA

     A metabolite of DPA with anti-inflammatory properties
  29. GC41208 17(S)-HDHA

    17(S)hydroxy Docosahexaenoic Acid, 17(S)HDoHE

     An oxidation product of DHA
  30. GC41206 14(S)-HDHA

    14(S)-HDoHE

     An anti-inflammatory lipid produced by macrophages
  31. GC41189 Ricinelaidic Acid An LTB4 antagonist
  32. GC41183 α-Carotene

    α-胡萝卜素

    A precursor of vitamin A
  33. GC41177 Lurasidone metabolite 14283 An active metabolite of lurasidone
  34. GC41151 Decursinol angelate Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A.
  35. GC41150 14,15-Leukotriene E4

    Eoxin E4, EXE4, 14,15LTE4

     A metabolite of 14,15-LTC4 with pro-inflammatory activity
  36. GC41149 11-trans Leukotriene E4

    11trans LTE4

     The C-11 double bond isomer of LTE4
  37. GC41148 14,15-Leukotriene D4

    Eoxin D4, EXD4, 14,15-LTD4

     A pro-inflammatory arachidonic acid metabolite
  38. GC41147 11-trans Leukotriene D4

    11trans LTD4

     A C-11 double bond isomer of LTD4
  39. GC41145 14,15-Leukotriene C4

    Eoxin C4, EXC4, 14,15LTC4

     A pro-inflammatory arachidonic acid metabolite
  40. GC41144 11-trans Leukotriene C4

    11trans LTC4

     A C-11 double bond isomer of LTC4
  41. GC41136 8(S),15(S)-DiHETE A dihydroxy fatty acid synthesized by 15-LO from 15(S)-HETE
  42. GC41131 5(S),6(S)-DiHETE A hydrolysis product of LTA4
  43. GC41129 5(S),6(R)-DiHETE A dihydroxy hydrolysis product of LTA4
  44. GC41128 5(S),6(R)-11-trans DiHETE A metabolite of LTA4
  45. GC41127 5(S),15(S)-DiHETE A dihydroxy fatty acid synthesized by 15-LO from 5(S)-HETE
  46. GC41126 5(S),12(S)-DiHETE A natural bioactive lipid
  47. GC41124 15(S)-HpETE

    15-羟基二十碳-5Z,8Z,11Z,13E-四烯酸

     A product of 15-LO metabolism of arachidonic acid
  48. GC41123 12-epi Leukotriene B4

    12epi LTB4

     LTB4 isomer with weak agonist activity at BLT1 and BLT2 receptors
  49. GC41122 12(S)-HpETE

    A 12-LO metabolite of arachidonic acid
  50. GC41107 Leukotriene B5

    LTB5

     A leukotriene
  51. GC41105 5(S)-HpEPE Produced by the action of 5-LO on EPA; LTA5 precursor

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