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14,15-Leukotriene C4 Sale

(Synonyms: Eoxin C4, EXC4, 14,15LTC4) 目录号 : GC41145

A pro-inflammatory arachidonic acid metabolite

14,15-Leukotriene C4 Chemical Structure

Cas No.:75290-60-7

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25μg
¥1,747.00
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50μg
¥3,323.00
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100μg
¥6,287.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTC4 is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTC4 is classified as an eoxin, because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTC4 as well. Little is known about the physiological actions of 14,15-LTC4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTC4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs resulting in plasma leakage - a hallmark of inflammation.

Chemical Properties

Cas No. 75290-60-7 SDF
别名 Eoxin C4, EXC4, 14,15LTC4
Canonical SMILES CCCCC[C@H](O)[C@H](SC[C@H](NC(CC[C@@H](C(O)=O)N)=O)C(NCC(O)=O)=O)/C=C/C=C/C=C\C/C=C\CCCC(O)=O
分子式 C30H47N3O9S 分子量 625.8
溶解度 DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 100 µ g/ml 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.598 mL 7.9898 mL 15.9795 mL
5 mM 0.3196 mL 1.598 mL 3.1959 mL
10 mM 0.1598 mL 0.799 mL 1.598 mL
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Research Update

Concentration of 14,15-Leukotriene C4 (eoxin C4) in bronchoalveolar lavage fluid

Clin Exp Allergy 2009 Sep;39(9):1348-52.PMID:19438588DOI:10.1111/j.1365-2222.2009.03261.x.

Background: There has been no information about the concentration of 14,15-Leukotriene C4, which is generated by 15- and 12-lipoxygenase and has been recently named eoxin C4, in biological fluids. Objective: To determine the clinical concentrations of eoxin C4 in various respiratory inflammatory diseases, we quantified eoxin C4 in relation to the concentrations of cysteinyl-leukotrienes (CysLTs) and 15-hydroxyeicosatetraenoic acid (15-HETE) in bronchoalveolar lavage fluid (BALF). Methods: BALF fluid was obtained from patients with a number of inflammatory lung diseases. Eoxin C4 and CysLTs were quantified by enzyme immunoassay in combination with high-performance liquid chromatography. Eoxin C4 immunoassay does not detect eoxin D4 or eoxin E4. 15-HETE was quantified by gas chromatography-mass spectrometry using (18)O-labeled compounds as an internal standard. Results: The concentration of eoxin C4 (median 1.4, range <1.12-6.7 pg/mL) was significantly lower than that of eoxin C4 or CysLTs (P<0.0001). The concentration of 15-HETE significantly correlated with those of LTC4 and CysLTs or the number and the percentage of eosinophils in BALF. On the other hand, eoxin C4 concentration did not correlate with eosinophil number or CysLTs concentration in BALF. Conclusions: This is the first study demonstrating the presence of eoxin C4 in human biological fluids. Further studies are necessary to elucidate the pathophysiological role of eoxin C4 in some respiratory inflammatory diseases.