Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC38729 2,5-Dimethylpyrazine
2,5-二甲基吡嗪,NSC 49139
2,5-Dimethylpyrazine (NSC 49139) is an endogenous metabolite.
GC38720 (R)-Trolox
(R)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸
(R)-Trolox 是水溶性维生素 E 类似物，是一种竞争性酪氨酸酶抑制剂，Ki 值为 0.83 mM，ID50 值为 1.88 mM。(R)-Trolox 具有比 (S) 对映异构体更强的酪氨酸酶亲和力 (Ki 值为 0.61 mM)。
GC45931 4(S),11(R)-DiHDoHE A neuropeptide with diverse biological activities
GC45926 Nelfinavir-d3 An internal standard for the quantification of nelfinavir
GC45909 17α-hydroxy Pregnenolone
17α-羟基妊娠烯醇酮,NSC 63853
A metabolite of pregnenolone
GC45818 Metoclopramide-d3
甲氧氯普安D3
An internal standard for the quantification of metoclopramide
GC45800 Cytarabine-13C3
Ara-C-13C3, 1-β-D-Arabinofuranosylcytosine-13C3
A neuropeptide with diverse biological activities
GC45768 Pranlukast-d4
ONO-1078-d4
A neuropeptide with diverse biological activities
GC45766 Amprenavir-d4
安瑞那韦 d4
A neuropeptide with diverse biological activities
GC45705 D-Kynurenine
犬尿氨酸
An antagonist of GPR109B
GC45687 Dasatinib N-oxide
达沙替尼N氧化物；达沙替尼杂质
A major metabolite of dasatinib
GC45673 7,8-Dihydroneopterin
7,8-二氢-D-新蝶呤
An antioxidant
GC45650 Des(benzylpyridyl) Atazanavir
Atazanavir metabolite M1
A metabolite of atazanavir
GC45615 3-hydroxy-3-methylglutaryl Coenzyme A (sodium salt)
DL-3-hydroxy-3-methylglutaryl-CoA, HMG-CoA, Hydroxymethylglutaryl-CoA
A neuropeptide with diverse biological activities
GC38703 NSC 8751
巴豆酸,(E)-2-Butenoic acid; (E)-Crotonic acid; trans-2-Butenoic acid; trans-Crotonic acid
NSC 8751 是一种内源性代谢产物。
GC38690 D-Glucuronic acid lactone
葡醛内酯; 葡糖醛酸內酯; D-Glucurono-6,3-lactone; D-Glucurono-γ-lactone; D-Glucuronolactone; Dicurone; Glucoxy; Glucurolactone; Glucurone
D-Glucurone is a glucuronic acid derivative that is used for treating canine hepatitis.
GC38689 Poly(4-vinylphenol)
聚（4-乙基苯酚）
Poly(4-vinylphenol) 是一种内源性代谢产物。
GC38688 Inosine 5'-monophosphate disodium salt (hydrate)
肌苷5-单磷酸二钠盐水合物,5'-IMP (disodium)(hydrate
Disodium 5'-inosinate monohydrate (Inosine 5'-monophosphate disodium salt hydrate) is an endogenous metabolite.
GC38684 (E)-m-Coumaric acid
3-羟基肉桂酸
3-hydroxycinnamic acid (meta-Coumaric acid, m-Coumaric acid, m-Coumarate) is an aromatic acid that can be found in vinegar.
GC38670 1-Hydroxyoctadecane
硬脂醇
1-Hydroxyoctadecane 是一种内源性代谢产物。
GC38669 3-Hydroxybenzoic acid 3-Hydroxybenzoic acid 是一种内源性代谢产物。
GC38660 Megestrol
甲地孕酮
Megestrol, a synthetic progestin, is approved for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis. Megestrol acetate (Megace) is one of the first progestational agents to be evaluated for use in the hormonal therapy of advanced breast cancer.
GC38654 Bis(2-ethylhexyl) phthalate
邻苯二甲酸二(2-乙基己)酯,Bis(2-ethylhexyl) phthalate; Ergoplast FDO; ESBO-D 82
Bis(2-ethylhexyl) phthalate (Dioctyl phthalate, DOP, Diplast O, ESBO-D 82, Ergoplast FDO, Ergoplast FDO-S, Etalon) induces DNA strand breaks and gene expression alterations in larval zebrafish Danio rerio.
GC38644 Glycodeoxycholic Acid
甘氨脱氧胆酸；甘氨去氧胆酸

A quantitative analytical standard guaranteed to meet MaxSpec^? identity, purity, stability, and concentration specifications
GC38640 IDH889 IDH889 是一种可口服利用的，脑渗透性的，变构和突变特异性的异柠檬酸脱氢酶 (IDH1) 抑制剂。IDH889 对 IDH1 R132* 突变型具有高效选择性，对 IDH1R132H、IDH1R132C 和 IDH1wt 作用的 IC50 值分别为 0.02 μM, 0.072 μM 和 1.38 μM。IDH889 具有高效的细胞内 2-HG 水平抑制作用，其 IC50 值为 0.014 μM。
GC38638 Euphol
大戟二烯醇
真酚(Euphol)是Euphorbia tirucalli中的主要成分,真酚可逆的抑制丝氨酸水解酶MGL活性(IC50 = 315 nM)。
GC38636 Glabrol
光甘草醇
Glabrol (Compound 1) 是从甘草根的乙醇提取物中分离得到的一种异戊二烯类黄酮，是一种有效且非竞争性的 ACAT (酰基辅酶 A:胆固醇酰基转移酶)抑制剂，对大鼠肝脏微粒体 ACAT 的 IC50 值为 24.6 μM。
GC38620 Dihydrorotenone
二氢鱼藤酮
Dihydrorotenone 是一种天然杀虫剂，是一种线粒体 (mitochondrial) 抑制剂。Dihydrorotenone 可能诱发帕金森综合症。Dihydrorotenone 通过触发内质网应激并激活 p38 信号通路来诱导人浆细胞凋亡 (apoptosis)
GC38604 Glomeratose A
球腺糖A
Glomeratose A 是一种乳酸脱氢酶 lactate dehydrogenase 抑制剂，是从远志 Polygala tenuifolia 分离的。
GC38593 Ethyl glucuronide
乙基Β-D-葡萄糖醛酸
Ethyl glucuronide 是一种内源性代谢产物。
GC38587 H-Arg-Lys-OH TFA H-Arg-Lys-OH TFA 是由 L-精氨酸和 L-赖氨酸残基形成的二肽。
GC38574 Cholesteryl arachidonate
Arachidonic Acid cholesteryl ester, Cholesterol Arachidonate, Cholesterol 5Z,8Z,11Z,14-Z-Eicosatetraenoic Acid ester, 20:4 Cholesteryl ester
A cholesterol ester
GC38560 Oleoylcarnitine
CAR 18:1, C18:1 Carnitine, L-Carnitine oleoyl ester, L-Oleoylcarnitine
A long-chain acylcarnitine
GC38556 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholine 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholine 是一种内源性代谢产物。
GC38552 Tetrahydrocortisol
氧戊环
An endogenous metabolite of cortisol
GC38503 HSP27 inhibitor J2
J2
HSP27抑制剂J2 (J2)是HSP27的抑制剂,能显著诱导异常HSP27二聚体形成,抑制HSP27大聚合物的生成。
GC38488 Hinokiflavone
扁柏双黄酮
Hinokiflavone, isolated from Selaginella P. Beauv, Juniperus phoenicea and Rhus succedanea, possesses excellent pharmacological activities, including anti-inflammatory, antioxidant and antitumor activity. Hinokiflavone induces apoptosis and inhibits migration of breast cancer cells via EMT signalling pathway.
GC38463 ASLAN003
ASLAN003
A DHODH inhibitor
GC38457 Lapaquistat
T-91485
Lapaquistat (T-91485) 是一种胆固醇生物合成 cholesterol biosynthesis 的抑制剂，是 TAK-475 的活性代谢产物。Lapaquistat 可以降低他汀类药物在降脂治疗中的肌毒性。
GC38452 Dehydrotrametenolic acid
去氢齿孔酸
Dehydrotrametenolic acid 是从茯苓 (Poria cocos) 的菌核中分离的甾醇。Dehydrotrametenolic acid 通过 caspase-3 途径诱导细胞凋亡。Dehydrotrametenolic acid 具有抗肿瘤活性，抗炎，抗糖尿病作用。
GC38440 Guaiazulene
愈疮奥
A sesquiterpene with diverse biological activities
GC38438 Synephrine
辛弗林; Oxedrine
Synephrine (Oxedrine), a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.
GC38382 CNDAC hydrochloride CNDAC hydrochloride 是可口服试剂 sapacitabine 的代谢物，为核苷酸类似物。
GC38371 (S)-(-)-Phenylethanol
S-(-)-苯乙醇
(S)-(-)-1-Phenylethanol ((S)-1-Phenylethanol, (S)-(-)-Phenylethanol) is an enantiomer of 1-Phenylethanol with flavor properties.
GC38370 N-Acetyl-L-leucine
N-乙酰-L-亮氨酸
N-acetyl-L-leucine is an active endogenous metabolite that accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus.
GC38369 (±)-Leucine
DL-亮氨酸,DL-Leucine; (RS)-Leucine
(±)-Leucine 是一种内源性代谢产物。
GC38368 3-Furanoic acid
3-糠酸
3-Furoic acid is an organic acid regularly occurring in urine of healthy individuals.
GC38367 2,4-Dihydroxypyrimidine-5-carboxylic Acid
脲嘧啶-5-羧酸
2,4-Dihydroxypyrimidine-5-carboxylic Acid (Uracil 5-carboxylic acid, Isoorotic acid, 5-Carboxyuracil) is an endogenous metabolite.
GC38366 Pyridoxylamine dihydrochloride
盐酸吡多胺; Pyridoxamine dihydrochloride

A 4-methylamine form of vitamin B₆
GC38364 (R)-Ornithine hydrochloride
D-鸟氨酸盐酸盐,(R)-Ornithine hydrochloride

An enantiomer of L-ornithine