Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC17906 S/GSK1349572
度鲁特韦; S/GSK1349572
A potent inhibitor of HIV integrase
GC11956 Raltegravir (MK-0518)
雷特格韦; MK-0518
Raltegravir (MK-0518) 是一种有效的整合酶 (IN) 抑制剂，用于治疗 HIV 感染。
GC15561 MK-2048 MK-2048 是一种有效的整合酶和 INR263K 抑制剂，IC50 分别为 2.6 nM 和 1.5 nM。
GC14466 Fluorouracil (Adrucil)
5-氟脲嘧啶; 5-FU
氟尿嘧啶 (Adrucil) (5-FU) 是尿嘧啶的类似物，在 C-5 位置用氟原子代替氢。
GC14996 Elvitegravir (GS-9137)
埃替拉韦,Elvitegravir,GS9137
An inhibitor of HIV-1 integrase
GC11923 BMS-707035
N-[(4-氟苯基)甲基1,6-二氢-5-羟基-1-甲基-6-氧代-2-(四氢-1,1-二氧-2H-1,2-噻嗪-2-基)-4-嘧啶甲酰胺
BMS-707035 是一种有效的口服活性 HIV-1 整合酶链转移抑制剂 (INSTI)。
GC13946 SNX-2112
PF-04928473
A potent Hsp90 inhibitor
GC11403 Radicicol
根赤壳菌素; Monorden
An inhibitor of Hsp90
GC11179 NVP-BEP800
NVP-BEP800
An Hsp90 inhibitor
GC14322 MPC-3100 An inhibitor of Hsp90
GC14636 KW-2478
KW2478,KW 2478
An Hsp90 inhibitor
GC11391 IPI-504 (Retaspimycin hydrochloride)
瑞他霉素盐酸盐,IPI 504, IPI504
IPI-504 (Retaspimycin hydrochloride) 是一种有效的 Hsp90 抑制剂，对 Hsp90 和 Grp9 的 EC50 均为 119 nM。
GC16361 Geldanamycin
格尔德霉素
Binds Hsp90 and GRP94, inhibits growth of cancer cells
GC12218 BIIB021
CNF2024
A potent, orally-available Hsp90 inhibitor
GC15295 AUY922 (NVP-AUY922)
VER-52296, AUY-922, AUY 922, Luminespib
AUY922 (NVP-AUY922)是一种高效且选择性的 HSP90抑制剂，对 HSP90α和 HSP90β的 IC₅₀ 值分别为 13nM和 21nM。
GC11720 17-AAG (KOS953)
坦螺旋霉素; 17-AAG; NSC 330507; CP 127374
17-AAG（格尔德霉素）是一种天然的苯醌安沙霉素抗生素，是第一个确定的 Hsp90 抑制剂。
GC13673 BMS-708163 (Avagacestat)
BMS-708163
A potent inhibitor of γ-secretase
GC17791 LY2811376
(4S)-4-[2,4-二氟-5-(5-嘧啶基)苯基]-5,6-二氢-4-甲基-4H-1,3-噻嗪-2-胺
A BACE1 inhibitor
GC12191 LY-411575
(AS)-N-[(1S)-2-[[(7S)-6,7-二氢-5-甲基-6-氧代-5H-二苯并[B,D]氮杂卓-7-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟-ALPHA-羟基苯乙酰胺
A γ-secretase inhibitor
GC17671 YO-01027 (Dibenzazepine, DBZ)
二苯并氮卓,gamma-Secretase Inhibitor XX,YO01027
An inhibitor of γ-secretase
GC14209 Apoptosis Activator 2
1-(3,4-二氯苄基)-1H-吲哚-2,3-二酮
An activator of caspases
GC10801 Disulfiram
双硫仑; Tetraethylthiuram disulfide; TETD
An irreversible inhibitor of aldehyde dehydrogenase
GC15899 MK-0752
顺式-4-[(4-氯苯基)磺酰基]-4-(2,5-二氟苯基)环己烷丙酸,MK 0752, MK0752
A potent inhibitor of γ-secretase
GC16197 RO4929097
N1-[(7S)-6,7-二氢-6-氧代-5H-二苯并[B,D]氮杂卓-7-基]-2,2-二甲基-N3-(2,2,3,3,3-五氟丙基)丙二酰胺,RG-4733

An inhibitor of γ-secretase
GC12942 DAPT (GSI-IX)
gamma-Secretase Inhibitor IX, DAPT, GSI-IX
DAPT (GSI-IX) 是一种具有口服活性的 γ-分泌酶抑制剂，对人原代神经元培养物中产生的总淀粉样蛋白-β (Aβ) 和 Aβ42 的 IC50 分别为 115 nM 和 200 nM。
GN10801 Senkyunolide I
洋川芎内酯I
Senkyunolide I 是从川芎中分离出来的，是一种抗偏头痛化合物。
GN10267 Loureirin B
龙血素 B
A flavonoid with diverse biological activities
GN10506 Umbelliferone
7-羟基香豆素; 7-Hydroxycoumarin; Hydrangin; NSC 19790
A derivative and metabolite of coumarin with diverse biological activities
GN10342 Chondroitin sulfate (from bovine)
硫酸软骨素; Chondroitin polysulfate sulfate (from bovine)
硫酸软骨素是五类糖胺聚糖之一，已广泛用于治疗骨关节炎。
GN10492 Allantoin
尿囊素; 5-Ureidohydantoin
A product of purine and uric acid metabolism
GN10289 Trigonelline
胡芦巴碱; Trigenolline
An alkaloid with diverse biological activities
GN10552 Syringic acid
丁香酸
A natural O-methylated phenolic acid
GN10423 Lipoic acid
硫辛酸
硫辛酸 ((R)-(+)-α-硫辛酸) 是一种抗氧化剂，是线粒体酶复合物的重要辅助因子。
GN10518 Chitosamine hydrochloride
盐酸氨基葡萄糖; D-(+)-Glucosamine hydrochloride; Chitosamine hydrochloride
An amino monosaccharide
GN10669 Glucosamine sulfate
硫酸氨基葡萄糖; D-Glucosamine sulfate
氨基葡萄糖硫酸盐（D-氨基葡萄糖硫酸盐）是一种氨基糖，是糖基化蛋白质和脂质生化合成的重要前体，用作膳食补充剂。
GN10306 Folic acid
叶酸; Vitamin B9; Vitamin M

An essential B vitamin
GN10290 Norcantharidin
去甲斑蝥素
An inhibitor of PP1 and PP2A
GN10810 Cordycepin
虫草素; 3'-Deoxyadenosine
Cordycepin（3’-deoxyadenosine; 虫草素）是一种核苷类似物，抑制聚腺苷酸化。
GN10676 Palmitic acid
棕榈酸
棕榈酸 (PA) 是人体中最常见的饱和脂肪酸，可以从饮食中提供，也可以从其他脂肪酸、碳水化合物和氨基酸内源合成。
GN10063 Arctigenin
牛蒡子苷元; (-)-Arctigenin
Arctigenin是一种天然木脂素化合物，已证实具有抗癌活性。Arctigenin具有强效的抗氧化、抗炎和抗病毒（甲型流感病毒）活性。
GN10227 Sodium Demethylcantharidate
去甲斑蝥酸钠

Extracted from Mylabris phqlarata pallas;Store the product in sealed, cool and dry condition
GN10555 Bilirubin
胆红素
A breakdown product of heme catabolism
GN10629 5,7-dihydroxychromone
5,7-二羟基色酮
A flavone decomposition product with diverse biological activities
GN10269 Wedelolactone
蟛蜞菊内酯
A natural NF-κB inhibitor
GN10545 Escin IA
七叶皂苷A
A triterpenoid saponin with diverse biological activities
GN10349 Ergosterol
麦角固醇; Ergosterin; Provitamin D; Provitamin D2
A fungal sterol
GN10783 (R) Ginsenoside Rh2
20(R)-人参皂苷Rh2
A steroid glycoside with diverse biological activities
GN10470 Eriodictyol
圣草酚
圣草酚是一种从中药中分离出来的黄酮类化合物，具有抗氧化和抗炎活性。
GN10040 Dehydrocorydaline
脱氢紫堇碱; 13-Methylpalmatine
An alkaloid with diverse biological activities
GN10091 Schaftoside
夏佛塔苷
A flavonoid C-glycoside with diverse biological activities