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5,7-dihydroxychromone Sale

(Synonyms: 5,7-二羟基色酮) 目录号 : GN10629

A flavone decomposition product with diverse biological activities

5,7-dihydroxychromone Chemical Structure

Cas No.:31721-94-5

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10mM (in 1mL DMSO)
¥357.00
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20mg
¥1,575.00
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产品描述

5,7-Dihydroxychromone is a natural antioxidant extracted from plants, such as peanut shell. It acts as an Nrf2/ARE signal activator [1]; or a PPARγ agonist [2].

NF-E2-related factor 2 (Nrf2)/antioxidant response element (ARE) signal has an important effect on the induction of antioxidant gene expression, the activation of Nrf2 can neutralize oxidative stress. Under normal state, Nrf2 is localized in the cytoplasm, antioxidant agents induce nuclear translocation of Nrf2 and subsequently make the Nrf2/ARE complex mediate the induction of antioxidant enzyme genes.

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor family;

PPAR isoforms (α, β/δ, and γ) are key regulators of glucose absorption, lipid metabolism, proliferation, and cellular differentiation. PPARγ agonists are commonly used as insulin sensitizers for the treatment of type 2 diabetes mellitus.

In vitro: 5,7-Dihydroxychromone (DHC) (0.4–10 μM) was found to protect against neuronal cell death and the ROS generation in a dose-dependent manner in 6-OHDA-induced SH-SY5Y cells. DHC (0.08–10 μM) also dose-dependently increased the induction of nuclear Nrf2, which has a binding affinity to ARE and activates ARE-driven phase II antioxidant enzymes; NQO1, HO-1, and GCLc[1]. Daphniphyllum macropodum fruit extract (DME) administration in vivo and its major component 5,7-dihydroxychromone (1, 5, and 10 μg/mL) treatment in vitro dose dependently increased the mRNA expressions of PPARγ and LXRα in 3T3-L1 cells, 5,7-dihydroxychromone (1 μg/mL ) also potently increased adipocyte differentiation, suggesting that it functions as a PPARγ agonist and has anti-diabetic properties[2]. 5,7-dihydroxychromone also demonstrated significant activity against HIV replication in H9 lymphocyte cells[3].

References:
[1].  Kim D W, Lee K, Kwon J, et al. Neuroprotection against 6-OHDA-induced oxidative stress and apoptosis in SH-SY5Y cells by 5, 7-Dihydroxychromone: Activation of the Nrf2/ARE pathway[J]. Life sciences, 2015, 130: 25-30.
[2].  Koo H J, Kwak J H, Kang S C. Anti-diabetic properties of Daphniphyllum macropodum fruit and its active compound[J]. Bioscience, biotechnology, and biochemistry, 2014, 78(8): 1392-1401.
[3].  Wu P L, Lin F W, Wu T S, et al. Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis[J]. Chemical and pharmaceutical bulletin, 2004, 52(3): 345-349.

Chemical Properties

Cas No. 31721-94-5 SDF
别名 5,7-二羟基色酮
化学名 5,7-dihydroxychromen-4-one
Canonical SMILES C1=COC2=CC(=CC(=C2C1=O)O)O
分子式 C9H6O4 分子量 178.14
溶解度 ≥ 7.05mg/mL in DMSO 储存条件 Store at -20°C, protect from light
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 5.6136 mL 28.0678 mL 56.1356 mL
5 mM 1.1227 mL 5.6136 mL 11.2271 mL
10 mM 0.5614 mL 2.8068 mL 5.6136 mL
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