Home >> Signaling Pathways >> Apoptosis >> KEAP1-Nrf2


The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.

  1. Cat.No. 产品名称 Information
  2. GC25351 Dimethyl itaconate Dimethyl itaconate can reprogram neurotoxic to neuroprotective primary astrocytes through the regulation of LPS-induced Nod-like receptor protein 3 (NLRP3) inflammasome and nuclear factor 2/heme oxygenase-1 (NRF2/HO-1) pathways.
  3. GC66354 Ezetimibe-d4-1 An internal standard for the quantification of ezetimibe
  4. GC66054 Nrf2 activator-4
  5. GC66004 K67
  6. GC65610 (R)-5-Hydroxy-1,7-diphenyl-3-heptanone
  7. GC64971 DDO-7263
  8. GC63933 S-Allylmercaptocysteine
  9. GC62957 Eriodictyol-7-O-glucoside A flavanone glucoside with diverse biological activities
  10. GC62936 Dimethyl fumarate D6
  11. GC61636 CBR-470-2
  12. GC61419 Dibenzoylmethane
  13. GC61338 Toralactone
  14. GC60159 Ezetimibe ketone
  15. GC50242 RA 839 RA 839 是 Keap1 的非共价小分子结合剂,Kd 约为 6 μM,是 Nrf2 信号传导的选择性激活剂。
  16. GC38819 ML334 An inhibitor of the Nrf2-Keap1 protein-protein interaction
  17. GC36773 Nrf2-IN-1
  18. GC36390 Keap1-Nrf2-IN-1
  19. GC35630 CDDO-EA
  20. GC35629 CDDO-dhTFEA
  21. GC44006 Kinsenoside A glycoside with diverse biological activities
  22. GC34642 KI696 isomer
  23. GC40226 Curcumin-d6 An internal standard for the quantification of curcumin
  24. GC34070 Brusatol (NSC 172924) A quassinoid with diverse biological activities
  25. GC34057 TBHQ (tert-Butylhydroquinone) Tert-butylhydroquinone (TBHQ) is an antioxidant compound which is used to prevent lipid peroxidation and shows multiple cytoprotective actions. It is an activator of Nrf2.
  26. GC34010 Danshensu (Dan shen suan A)


  27. GC33815 4-Hydroxyphenylacetic acid A phenolic acid with anti-inflammatory and anti-steatotic activities
  28. GC33092 Hesperin An isothiocyanate with diverse biological activities
  29. GC32723 CDDO-Im (RTA-403) An activator of Nrf2 signaling
  30. GC31783 Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) Methyl protocatechuate (Methyl 3,4-dihydroxybenzoate, 3,4-Dihydroxybenzoic acid methyl ester, Protocatechuic Acid Methyl Ester) is also known as Protocatechuic Acid Methyl Ester. Protocatechuic Acid, a dihydroxybenzoic acid, is a major metabolite of antioxidant polyphenols found in green tea with antioxidant and anti-inflammatory effects.
  31. GC31691 (+)-DHMEQ
  32. GC31648 4-Octyl Itaconate

    4-Octyl Itaconate 是一种可渗透细胞的衣康酸酯衍生物。

  33. GC31321 KI696
  34. GC19254 ML385

    An inhibitor of Nrf2

  35. GC11302 Hinokitiol A tropolone with diverse biological activities
  36. GC13058 NK 252 A Nrf2 activator
  37. GC15457 Pyridoxine A 4-methanol form of vitamin B6
  38. GC14016 Sulforaphane A class I and II HDAC inhibitor with anticancer activity
  39. GC16625 CDDO-TFEA A synthetic triterpenoid with potent anticancer and neuroprotective activity
  40. GC12545 2-HBA An indirect inhibitor of Keap1-Nrf2 interactions
  41. GC12821 Oltipraz A Nrf2 and CAR activator
  42. GC13693 Omaveloxolone (RTA-408) A synthetic triterpenoid that blocks Keap1/Nrf2 signaling
  43. GC17393 Pyridoxine HCl A 4-methanol form of vitamin B6
  44. GC16590 Dimethyl Fumarate An antioxidant with immunological actions
  45. GC15605 Ezetimibe A cholesterol transport inhibitor
  46. GC14787 Curcumin A yellow pigment with diverse biological activities
  47. GC11572 Bardoxolone methyl A synthetic triterpenoid with potent anticancer and antidiabetic activity
  48. GC15371 Bardoxolone An anti-inflammatory compound that activates Nrf2/ARE signaling
  49. GN10629 5,7-dihydroxychromone A flavone decomposition product with diverse biological activities
  50. GN10741 Garcinone D A xanthone with diverse biological activities
  51. GN10318 Danshensu A salvianolic acid with diverse biological activities

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